METTLER TOLEDO XS Micro Balance
| Brand | METTLER TOLEDO |
|---|---|
| Origin | Switzerland |
| Model | XS Micro Balance |
| Readability | 0.001 mg / 0.01 mg (dual range) |
| Max Capacity | 0.8 g / 3.1 g (dual range) |
| Repeatability (sd) | 0.0008 mg / 0.006 mg |
| Linearity Error | ±0.01 mg |
| Typical Stabilization Time | 6 s |
| Pan Diameter | Ø27 mm |
| Design | Separated weighing unit and display/control unit |
| Built-in Applications | Weighing, Statistics, Formulation, Counting, Percentage, Density, Dynamic Weighing |
| Compliance | GWP® Excellence integrated risk-based validation support |
Overview
The METTLER TOLEDO XS Micro Balance is an ultra-precise analytical instrument engineered for trace-level mass determination in regulated laboratory environments. Utilizing electromagnetic force compensation (EMFC) technology, it delivers sub-microgram resolution with exceptional long-term stability and thermal independence. Its dual-range architecture—offering 0.001 mg readability at 0.8 g capacity and 0.01 mg readability up to 3.1 g—enables seamless transition between ultra-sensitive micro-weighing tasks and higher-capacity routine operations without compromising metrological integrity. Designed and manufactured in Switzerland, the XS series adheres to ISO/IEC 17025 traceability requirements and integrates seamlessly into GLP, GMP, and FDA 21 CFR Part 11–compliant workflows through hardware-level design and embedded software safeguards.
Key Features
- Physically separated weighing cell and control/display unit—minimizes thermal drift caused by electronics heating, ensuring consistent accuracy across extended operation cycles.
- Adaptive environmental compensation algorithms automatically adjust for air density, temperature gradients, and vibration sensitivity—critical for labs with variable HVAC performance or non-dedicated weighing rooms.
- GWP® Excellence—a built-in, configurable quality assurance framework that monitors operational status, prompts recalibration based on usage history and environmental deviation, and generates audit-ready calibration logs compliant with ISO 9001 and pharmacopeial standards.
- Dual-range capability enables method flexibility: high-resolution weighing of reference standards or active pharmaceutical ingredients (APIs), followed by rapid formulation checks at elevated capacities—all within a single instrument footprint.
- Electromagnetic force compensation transducer with monolithic quartz beam construction ensures mechanical hysteresis < 0.0005 mg and zero-point stability < 0.001 mg over 24 hours under controlled conditions.
Sample Compatibility & Compliance
The XS Micro Balance accommodates a broad spectrum of sample types—including hygroscopic powders, volatile solvents, static-prone polymers, and nanomaterial dispersions—through optional accessories such as the filter paper weighing kit (designed per EPA Method 201A and ISO 12103-1 for PM2.5/PM10 gravimetric analysis) and the compact U-shaped antistatic device (operating at < 1 kV surface potential). All models comply with OIML R 76-1 Class I accuracy requirements and meet essential metrological criteria outlined in USP , EP 2.1.3, and ASTM E898–22. The balance’s internal diagnostics log meets ALCOA+ data integrity principles, supporting full traceability during regulatory inspections.
Software & Data Management
Embedded firmware supports direct integration with METTLER TOLEDO LabX® software via Ethernet or USB, enabling centralized method management, automated report generation (PDF/CSV), electronic signature enforcement, and secure user role assignment (admin, operator, reviewer). All weighing events—including tare, net weight, statistics, and density calculations—are timestamped, digitally signed, and stored with immutable audit trails. Raw data export conforms to SDTM and CDISC standards for clinical trial material quantification. Optional connectivity to LIMS systems is supported via HL7 and OPC UA protocols.
Applications
- Pharmaceutical development: Accurate dispensing of potent compounds (e.g., cytostatics, peptides) where dose uniformity requires ≤0.1% RSD at sub-milligram levels.
- Materials science: Gravimetric characterization of catalysts, battery electrode coatings, and thin-film deposition yields.
- Environmental testing: Filter-based particulate matter (PM) mass determination per ISO 10473 and EN 12341.
- Reference standard preparation: Certified reference material (CRM) dilution and aliquoting under ISO Guide 35 requirements.
- Academic research: Isotope ratio mass spectrometry (IRMS) sample loading, microcalorimetry sample preparation, and single-crystal growth monitoring.
FAQ
What does “dual-range” mean in the XS3DU model specification?
Dual-range refers to two independent weighing modes within one instrument: a high-sensitivity mode (0.001 mg readability, 0.8 g max) optimized for micro-quantities, and a high-capacity mode (0.01 mg readability, 3.1 g max) for faster routine tasks—both calibrated and validated independently.
Is the XS Micro Balance compatible with 21 CFR Part 11 requirements?
Yes—when used with LabX software and configured with electronic signatures, audit trail logging, and role-based access control, it fulfills predicate rule requirements for electronic records and signatures.
How does the GWP® Excellence function support compliance?
It provides real-time risk assessment of measurement uncertainty, recommends recalibration intervals based on usage intensity and environmental data, and auto-generates GWP® Verification reports aligned with ISO/IEC 17025 clause 6.5.
Can the balance be installed in a laminar flow hood?
Yes—its low-power consumption (< 5 W), minimal heat dissipation, and optional antistatic accessories make it suitable for ISO Class 5 cleanroom environments when mounted on vibration-isolated platforms.
What documentation is supplied for qualification?
Factory-issued IQ/OQ documentation, EU Declaration of Conformity, traceable calibration certificate (NIST-traceable weights), and GWP® Risk Assessment template are included with each unit.
