NAYO A96 Fully Automated Liquid Handling Workstation
| Brand | NAYO |
|---|---|
| Origin | Shanghai, China |
| Manufacturer Type | Authorized Distributor |
| Country of Origin | China |
| Model | A96 |
| Pricing | Available Upon Request |
Overview
The NAYO A96 Fully Automated Liquid Handling Workstation is a high-precision, 96-channel benchtop platform engineered for reproducible, walk-away liquid transfer across life science, clinical diagnostics, and pharmaceutical R&D laboratories. Built upon NAYO’s proprietary FAN (Flexible Automation Network) architecture, the A96 implements a modular robotic core that integrates Cartesian X-Y-Z motion control with intelligent end-effector coordination. Its measurement principle relies on positive displacement pipetting—calibrated air-displacement or low-volume positive-displacement tips—to achieve accurate aspiration, dispensing, serial dilution, plate replication, and reformatting operations. Designed for ISO/IEC 17025-compliant environments and aligned with GLP/GMP documentation requirements, the A96 supports audit-ready operation logs, user access controls, and electronic signature capabilities per FDA 21 CFR Part 11 when deployed with validated software configurations.
Key Features
- Modular 96-Channel Architecture: Combines dual independent 2-channel flexible pipetting modules with an 8-channel fixed-position head, enabling simultaneous multi-step protocols such as master mix preparation followed by sample distribution.
- Adaptive Deck Configuration: X-axis deck layout supports up to 12 customizable plate positions; users define deck maps via software to accommodate SBS-standard microplates (96-, 384-, 1536-well), tube racks (1.5 mL, 2.0 mL, 15 mL, 50 mL), and custom labware via barcode-assisted registration.
- Intelligent Liquid Level Detection: Equipped with both passive liquid level detection (pLLD) for gross volume sensing and capacitive liquid level detection (cLLD) for sub-microliter precision—critical for viscous or volatile reagents and low-volume transfers down to 1 µL.
- Biosafety-Ready Options: Optional HEPA filtration (ISO Class 5 laminar flow) and integrated 254 nm UV-C irradiation module enable operation in BSL-2–compatible workflows; UV exposure cycles are programmable and logged for traceability.
- Third-Party Device Integration: Standardized RS-232, USB 3.0, and Ethernet interfaces support synchronization with external instruments including centrifuges, thermal cyclers, readers, and storage systems via open API protocols (RESTful JSON over TCP/IP).
Sample Compatibility & Compliance
The A96 accommodates standard polypropylene, polystyrene, and cyclo-olefin copolymer (COC) consumables compliant with ANSI/SBS standards. It handles aqueous buffers, cell lysates, serum, PCR master mixes, and ethanol-based solutions within viscosity ranges up to 20 cP at 20 °C. All pipetting operations adhere to ISO 8655-6 (volumetric accuracy verification) and ASTM E2758 (performance criteria for automated liquid handlers). The system meets CE marking requirements under the EU Machinery Directive 2006/42/EC and Electromagnetic Compatibility Directive 2014/30/EU. For regulated environments, full IQ/OQ documentation packages—including calibration certificates traceable to NIST standards—are available upon request.
Software & Data Management
Controlled by NAYO’s LHS Pro v4.2 software suite, the workstation provides drag-and-drop protocol builder, real-time execution monitoring, and integrated error recovery logic. All run logs—including timestamped pipette tip usage, volume dispensed per channel, and cLLD event flags—are stored in encrypted SQLite databases with optional export to CSV, PDF, or LIMS-compatible XML formats. Role-based user permissions (Admin, Operator, Viewer) enforce separation of duties; electronic signatures comply with 21 CFR Part 11 Annex 11 when paired with time-synchronized network authentication servers. Audit trails record all configuration changes, method edits, and instrument events with immutable timestamps.
Applications
- High-throughput ELISA and immunoassay plate setup
- NGS library normalization and pooling (e.g., Illumina TruSeq, PacBio SMRTbell)
- Cell-based assay seeding and compound dosing in oncology and neuropharmacology screening
- qPCR and digital PCR reaction assembly with low-volume master mix consistency
- Automated QC sample prep for biologics stability studies (ICH Q5C)
- Biobank sample aliquoting and inventory management integration
FAQ
Does the A96 support variable tip spacing for non-standard plate formats?
Yes—the 2-channel flexible pipetting module features motorized tip spacing adjustment from 4.5 mm to 9 mm, enabling direct transfer between 96-well plates and 384-well plates without intermediate tube steps.
Can I validate pipetting performance per ISO 8655 using built-in tools?
The system includes automated gravimetric validation routines compatible with certified analytical balances (0.01 mg resolution); raw mass data is exported for statistical analysis per ISO 8655-6 Annex B.
Is remote monitoring supported during unattended overnight runs?
Yes—via secure HTTPS web interface with live status dashboard, email/SMS alerting on critical events (e.g., tip jam, lid open, low reagent), and TLS 1.2–encrypted log streaming to central servers.
What maintenance intervals are recommended for long-term reliability?
Daily tip ejection check, weekly cLLD calibration, and quarterly Z-axis belt tension verification are documented in the Maintenance Manual; service contracts include predictive wear-part replacement based on actuation cycle counters.
