Ortoalresa Magnus 22 R High-Capacity Floor-Standing Refrigerated Centrifuge

Overview

The Ortoalresa Magnus 22 R is a high-capacity, floor-standing refrigerated centrifuge engineered for demanding routine and research applications in life science, clinical diagnostics, and bioprocessing laboratories. Designed according to the principles of fixed-angle rotor sedimentation dynamics and governed by ISO 21501-4–compliant mechanical stability criteria, the Magnus 22 R delivers precise, reproducible separation of biological macromolecules—including nucleic acids, proteins, organelles, and viral particles—under rigorously controlled thermal conditions. Its vertical architecture minimizes footprint while maximizing internal chamber volume, enabling operation in constrained laboratory environments without compromising accessibility or ergonomic loading. The unit maintains temperature uniformity across the entire rotor cavity—even at maximum rotational speed—via a closed-loop refrigeration system utilizing R-449A, an environmentally compliant hydrofluoroolefin (HFO) refrigerant with negligible ozone depletion potential (ODP = 0) and low global warming potential (GWP ≈ 139). Temperature control spans −20 °C to +40 °C in 1 °C increments, with active pre-cooling and post-run hold functions ensuring sample integrity throughout multi-step workflows.

Key Features

• Brushless induction motor with zero-maintenance operation and extended service life; no carbon brushes or commutators requiring replacement
• TFT color touchscreen interface (≥3 m visibility) displaying real-time RPM, RCF, elapsed time, set temperature, acceleration/deceleration profiles, and imbalance detection status
• Progressive Controlled Braking System (PCBS) with 175 selectable ramp profiles to prevent resuspension of pelleted material during deceleration
• Unbalance Localization System (ULS) that identifies the specific tube position(s) causing rotor imbalance and halts operation before mechanical stress exceeds EN 61010-2-020 thresholds
• Automatic rotor recognition via embedded RFID tags; dynamic RCF calculation adjusts for adapter geometry and tube fill level
• Stainless-steel centrifuge chamber (AISI 304) with smooth, crevice-free surfaces compatible with autoclaving (121 °C, 20 min) and routine decontamination per CLSI M29-A4 guidelines
• Dual-locking motorized lid with emergency manual release, anti-drop mechanism, and optical interlock verification for GLP/GMP-compliant audit trails
• Energy-saving auto-shutdown after 8 hours of idle operation, compliant with EU Ecodesign Directive (EU) 2019/2023

Sample Compatibility & Compliance

The Magnus 22 R accommodates a broad spectrum of primary and secondary containers without hardware modification. Standard configurations support 4 × 750 mL conical centrifuge bottles, 6 × 500 mL swing-out buckets, or high-throughput formats including 2 × 96-well microplates (with appropriate carriers), 12 × 15 mL conical tubes, and clinical blood collection tubes (e.g., EDTA, serum separator). All rotors and adapters are validated for sterilization under ISO 17664-1 and meet USP requirements for reusable device reprocessing. The system complies fully with IEC 61010-1:2010 + A1:2019 for safety of laboratory equipment and IEC 61326-1:2021 for electromagnetic compatibility. It supports 21 CFR Part 11–compliant data integrity when interfaced with validated LIMS or ELN platforms via RS-232 or optional Ethernet module.

Software & Data Management

Embedded firmware provides 40 user-programmable methods with password protection, timestamped execution logs, and parameter recall functionality. Each protocol stores final rotor speed, RCF, temperature setpoint, run duration, acceleration/deceleration profile, and ULS event history. Data export is supported via USB port in CSV format for traceable reporting. Optional PC connectivity enables remote monitoring, method synchronization across multiple instruments, and integration with electronic lab notebooks adhering to ALCOA+ principles (Attributable, Legible, Contemporaneous, Original, Accurate, Complete, Consistent, Enduring, Available). Audit trail records include operator ID, date/time stamps, parameter changes, and error codes—all retained for ≥12 months as required under FDA guidance for computerized systems used in regulated environments.

Applications

• Large-volume cell harvesting (e.g., mammalian suspension cultures, yeast fermentations) at industrial pilot scale
• Clinical specimen processing: plasma separation from whole blood, PBMC isolation, platelet-rich plasma (PRP) preparation
• Viral vector purification workflows requiring cryo-stable conditions and high RCF for capsid pelleting
• Downstream processing of monoclonal antibodies, where temperature-sensitive aggregates must be preserved during clarification
• Environmental microbiology: concentration of waterborne pathogens (e.g., Legionella, enteroviruses) from large-volume samples
• Biobanking: long-term storage preparation of cryopreserved cell suspensions with minimal thermal cycling

FAQ

What is the minimum achievable temperature at maximum speed?
The Magnus 22 R maintains ≤4 °C in the rotor chamber at 14,300 rpm, verified per ISO 21501-4 Annex B thermal mapping protocol.

Are rotors certified for autoclaving?
Yes—stainless-steel fixed-angle rotors and aluminum adapters are validated for 121 °C, 20-minute steam sterilization cycles per ISO 17664-1 Annex C.

Does the system support FDA 21 CFR Part 11 compliance?
When connected to a validated third-party software platform with electronic signature capability, full Part 11 compliance—including audit trail, role-based access, and electronic record retention—is achievable.

How does the Unbalance Localization System (ULS) function during runtime?
ULS uses vibration spectral analysis and phase-shift detection to triangulate the angular position of mass asymmetry with ±5° accuracy, triggering immediate deceleration and visual alert on the touchscreen.

Is refrigerant R-449A compatible with existing service infrastructure?
R-449A is a drop-in replacement for R-404A and R-507 in most servicing scenarios; however, technicians must use dedicated recovery equipment rated for HFO blends per EPA SNAP Program requirements.