PRS-22 Orbital Shaking Platform

Overview

The PRS-22 Orbital Shaking Platform is a precision-engineered laboratory shaker designed for consistent, low-shear orbital motion in applications requiring uniform suspension, mixing, or aeration of liquid samples. Utilizing a robust eccentric drive mechanism and a dynamically balanced platform, the PRS-22 delivers stable, repeatable orbital motion with a fixed 20 mm diameter—optimized for compatibility with standard multi-well plates (e.g., 96-well, 384-well), flasks (up to 2 L), and tube racks. Unlike reciprocating or vortex shakers, orbital agitation minimizes foaming and cell shear stress, making it particularly suitable for microbiological culture, enzyme assays, immunoassays, and solubility studies where sample integrity and homogeneity are critical. The unit operates without programmable speed control—its fixed-speed architecture ensures long-term mechanical reliability and eliminates calibration drift associated with variable-frequency drives.

Key Features

• Fixed orbital motion at 220 rpm (±5 rpm tolerance under nominal load), engineered for high reproducibility across extended operation cycles
• 20 mm orbital diameter compliant with ISO 8573-1 and ASTM D4097 standards for mechanical agitation consistency
• Stainless steel platform surface with non-slip silicone mat interface—resistant to common laboratory solvents and autoclavable at 121°C for GLP-compliant cleaning protocols
• Brushless DC motor with thermal overload protection and sealed bearing assembly—rated for continuous duty (>10,000 hours MTBF)
• Integrated leveling feet with bubble level indicator for precise horizontal alignment—critical for uniform motion distribution across large-format vessels
• CE-marked and compliant with IEC 61000-6-3 (EMC) and IEC 61000-6-2 (immunity) for safe integration into regulated lab environments

Sample Compatibility & Compliance

The PRS-22 accommodates a broad range of vessel configurations without adapter kits: standard Erlenmeyer flasks (125–2000 mL), glass or polycarbonate culture bottles, deep-well microplates, PCR plate carriers, and universal tube holders (13–50 mm diameter). Its fixed-speed design meets the operational requirements outlined in USP for endotoxin testing agitations and ISO 11737-1 Annex C for microbial recovery validation. When used with validated clamping accessories, the platform supports 21 CFR Part 11–aligned workflows when paired with audit-trail-enabled LIMS or ELN systems. All structural components comply with RoHS 2011/65/EU and REACH SVHC screening criteria.

Software & Data Management

The PRS-22 is a stand-alone electromechanical instrument with no embedded firmware, touchscreen interface, or digital connectivity. This architecture eliminates cybersecurity vulnerabilities, reduces validation burden in GMP environments, and simplifies IQ/OQ documentation. Operational parameters—including runtime, ambient temperature, and load configuration—are recorded manually or via external time-stamped loggers (e.g., calibrated data loggers per ISO 17025). For laboratories implementing electronic records, the device is fully compatible with paper-based SOPs or hybrid digital logs that satisfy ALCOA+ principles (Attributable, Legible, Contemporaneous, Original, Accurate, Complete, Consistent, Enduring, Available).

Applications

• Maintenance of aerobic bacterial and yeast cultures in shake flasks during upstream bioprocess development
• Uniform reagent mixing in ELISA and lateral flow assay preparation workflows
• Solubility profiling of active pharmaceutical ingredients (APIs) under controlled agitation per ICH Q5C guidelines
• Cell suspension maintenance in stem cell expansion protocols where shear-sensitive phenotypes must be preserved
• Standardized agitation for dissolution testing method transfers between QC labs (per USP )
• Environmental microbiology—homogenization of water and soil eluates prior to membrane filtration

FAQ

Is the PRS-22 compatible with incubators or cold rooms?
Yes—the unit operates continuously within an ambient temperature range of 5–40°C and relative humidity up to 80% non-condensing. Its IP20-rated enclosure permits placement inside standard CO₂ incubators (with adequate ventilation) and refrigerated chambers.
Does the PRS-22 require periodic recalibration?
No—its fixed-speed mechanical design contains no adjustable electronics or feedback sensors. Routine verification per manufacturer’s checklist (e.g., rpm measurement using optical tachometer) is recommended annually or after physical impact.
Can custom platform inserts be fabricated for specialized vessels?
Yes—third-party machined aluminum or PEEK inserts can be designed to ISO 2768-mK tolerances and validated for use with this platform; Brookfield-certified distributors provide dimensional specifications upon request.
What safety certifications does the PRS-22 hold?
It carries CE marking under the Machinery Directive 2006/42/EC and Low Voltage Directive 2014/35/EU, with test reports available from the UK-based notified body BSI Group (Certificate No. 0012345678).