Reilap Novisar Apply Series Liquid Chromatography Tandem Mass Spectrometer (LC-MS/MS)
| Brand | Reilap |
|---|---|
| Origin | Zhejiang, China |
| Manufacturer Type | Authorized Distributor |
| Regional Classification | Domestic (China) |
| Model | Novisar Apply Series |
| Price Range | USD 140,000 – 280,000 |
| Instrument Type | Triple Quadrupole |
| Application Scope | Specialized |
| Mass Range | 5–2000 amu (extendable to 5–2200 amu) |
| Sensitivity | (1) ESI+, MRM mode: 1 pg reserpine, S/N ≥ 1,200,000:1 (up to 2,000,000:1) |
| (2) ESI−, MRM mode | 1 pg chloramphenicol, S/N ≥ 1,200,000:1 (up to 2,000,000:1) |
| Resolution | 0.4–2 amu |
Overview
The Reilap Novisar Apply Series Liquid Chromatography Tandem Mass Spectrometer (LC-MS/MS) is a purpose-built triple quadrupole system engineered for high-sensitivity, high-selectivity quantitative analysis in regulated and research-intensive environments. Operating on the principle of electrospray ionization (ESI) coupled with tandem mass spectrometry in Multiple Reaction Monitoring (MRM) mode, the instrument delivers exceptional signal-to-noise ratios and robust reproducibility across complex biological, environmental, and pharmaceutical matrices. Its integrated architecture minimizes footprint without compromising vacuum integrity or thermal stability—critical for sustained operation in multi-user laboratory settings. The system is designed to meet the analytical rigor required for compliance-driven workflows, including those aligned with ISO/IEC 17025, USP , and FDA Guidance for Bioanalytical Method Validation.
Key Features
- High-Efficiency Ion Optics: A high-pressure quadrupole ion guide enhances ion transmission efficiency by maintaining optimal collisional focusing under variable flow rates and solvent compositions.
- 180° Bent Axial Collision Cell: This patented geometry increases dwell time and collision cross-section while minimizing neutral particle carryover—reducing chemical noise and improving MRM specificity.
- Pulsed High-Density Detection: A proprietary pulse-counting detector architecture captures low-abundance ions with near-zero dead-time loss and real-time noise suppression via digital signal processing.
- Dual Orthogonal ESI Source: Features independently optimized spray and sampling axes to decouple droplet desolvation from ion extraction—delivering superior ion yield and resilience against matrix-induced suppression.
- Heated Reverse Curtain Gas Interface: Incorporates thermally stabilized cone design with adjustable curtain gas flow to enhance desolvation and reduce non-volatile residue accumulation at the interface.
- RF Frequency Adaptive Control: Dynamically stabilizes quadrupole DC/RF voltage ratios across ambient temperature and humidity fluctuations, ensuring long-term mass accuracy and peak shape consistency.
- Environmental Resilience: Patented thermal-humidity compensation algorithms maintain operational stability across 15–30 °C and 30–80% RH—eliminating the need for climate-controlled instrument rooms in many regional laboratories.
Sample Compatibility & Compliance
The Novisar Apply Series accommodates a broad range of sample types—including plasma, urine, tissue homogenates, soil extracts, water concentrates, and plant matrices—without requiring extensive pre-purification. Its dual-mode ESI source supports both polar and moderately non-polar analytes, while the extended mass range (up to 2200 amu) enables characterization of larger metabolites, modified peptides, and small-molecule adducts. For regulatory compliance, the system supports audit-trail-enabled method validation, electronic signatures per 21 CFR Part 11, and GLP/GMP-aligned data archiving protocols. All calibration and tuning procedures are traceable to NIST-traceable standards, and routine performance verification meets ASTM D7622 and ISO 17025 method validation criteria.
Software & Data Management
The Novisar Apply Series runs on a fully localized English/Chinese bilingual software suite—comprising Novisar Tune (instrument control), Novisar Quant (quantitative workflow engine), and Novisar Insight (AI-assisted data review). The platform includes one-click auto-tuning and mass calibration routines validated per ICH Q2(R2) guidelines. Quantitative methods support internal standard normalization, matrix-matched calibration curves, and weighted linear regression (1/x or 1/x²). Integrated AI modules assist in peak detection refinement, interference flagging, and outlier identification based on retention time drift, isotopic pattern fidelity, and signal symmetry metrics. Raw data files adhere to mzML 1.1.0 format; export options include CSV, PDF analytical reports, and LIMS-compatible XML schemas.
Applications
- Food Safety: Quantification of pesticide residues (organochlorines, organophosphates), veterinary drug contaminants (macrolides, β-agonists), and adulterants (melamine, Sudan dyes) at sub-ppq levels in complex food matrices.
- Environmental Analysis: Trace-level monitoring of emerging contaminants—including PFAS, PPCPs, PAHs, and PCBs—in wastewater, sediment, and airborne particulate matter.
- Pharmaceutical Development: PK/PD studies, genotoxic impurity screening (e.g., alkyl sulfonates), herbal pesticide residue testing, and structural confirmation of active pharmaceutical ingredients (APIs).
- Clinical & Diagnostic Research: Targeted quantification of vitamins (B12, D2/D3), catecholamines, steroid hormones, tumor markers (e.g., CEA, PSA), and acylcarnitines for inborn errors of metabolism.
- Forensic Toxicology: Multi-analyte screening of novel psychoactive substances (NPS), rodenticides, mycotoxins, and designer drugs in hair, blood, and wastewater epidemiology samples.
- Life Sciences: Targeted metabolomics (TCA cycle intermediates, neurotransmitters), lipidomics (phosphatidylcholines, sphingomyelins), and peptide-level quantification in SRM/MRM-based proteomics workflows.
FAQ
Is the Novisar Apply Series compliant with 21 CFR Part 11 for regulated laboratories?
Yes—the software supports role-based user access, electronic signatures, full audit trails, and immutable raw data storage as required for FDA-regulated bioanalysis and quality control environments.
Can the system be integrated into existing LIMS or ELN platforms?
Yes—via standardized API interfaces and configurable data export templates compatible with major LIMS vendors (e.g., LabWare, Thermo Fisher SampleManager, STARLIMS).
What maintenance intervals are recommended for routine operation?
Ion source cleaning is recommended every 2–4 weeks depending on sample complexity; collision cell and detector recalibration is advised quarterly; full system performance verification should be conducted semi-annually per ISO/IEC 17025 Annex A.3.
Does the instrument support both positive and negative ionization modes during a single run?
No—polarity switching requires manual reconfiguration of source parameters; however, rapid polarity-switching methods (≤ 500 ms dwell) are supported via timed polarity switching in scheduled MRM acquisition.
Is remote monitoring and troubleshooting available?
Yes—the system includes secure remote diagnostics capability with TLS-encrypted session handshaking and optional vendor-supported service tier agreements for proactive performance analytics.
