Sanotac SP1020 Preparative High-Pressure Solvent Delivery Pump (100 mL Plunger Head, 20 MPa)
| Brand | Sanotac |
|---|---|
| Origin | Shanghai, China |
| Manufacturer Type | OEM Manufacturer |
| Product Origin | Domestic (China) |
| Model | SP1020 |
| Max. Operating Pressure | 20 MPa |
| Flow Rate Range | 0.01–100.00 mL/min |
| Flow Increment | 0.01 mL/min |
| Flow Accuracy | ±0.5% |
| Flow Precision (RSD) | ≤0.1% |
| Pressure Pulsation | ≤0.2 MPa |
| Display | 256×64 dot-matrix backlit LCD |
| Control Interface | Front-panel keypad + RS232/USB open communication protocol compliant with ASTM E1381 and FDA 21 CFR Part 11 audit trail requirements |
Overview
The Sanotac SP1020 Preparative High-Pressure Solvent Delivery Pump is an engineered solution for scalable liquid chromatography applications requiring precise, stable, and reproducible solvent delivery at elevated pressures. Designed specifically for preparative HPLC, flash chromatography, and process-scale purification workflows, the SP1020 employs a dual-plunger parallel architecture with floating plunger technology to maintain mechanical integrity and seal longevity under sustained high-pressure operation up to 20 MPa (2900 psi). Its microprocessor-controlled fluidic system integrates real-time chamber pressure feedback to dynamically compensate for solvent compressibility and refilling transients—critical for maintaining flow stability across wide viscosity and temperature gradients. Unlike analytical-grade pumps optimized for low-flow precision, the SP1020 prioritizes robustness, thermal inertia management, and volumetric fidelity in the 0.01–100.00 mL/min range—enabling seamless transition from method development to gram- to kilogram-scale separations.
Key Features
- Dual-plunger parallel pumping mechanism with floating plunger design ensures uniform load distribution and extends seal service life beyond 10,000 operational hours under continuous 20 MPa conditions.
- Cam-profile flow compensation algorithm minimizes pulsation amplitude to ≤0.2 MPa, reducing baseline noise in UV/Vis and mass-sensitive detectors during gradient elution.
- Multi-point flow calibration curves (10 user-definable points) correct for nonlinearity across the full dynamic range, achieving ±0.5% absolute flow accuracy and ≤0.1% RSD repeatability per ICH Q2(R2) verification guidelines.
- 256×64 dot-matrix self-luminous LCD display with adjustable backlight provides consistent contrast across viewing angles—essential for glove-box or fume hood integration.
- Open RS232/USB communication protocol supports bidirectional control and status reporting, enabling native integration with third-party chromatography data systems (CDS), LIMS, and automated fraction collectors per ASTM E1381–92 and FDA 21 CFR Part 11 compliance frameworks.
Sample Compatibility & Compliance
The SP1020 accommodates a broad spectrum of mobile phases including aqueous buffers, acetonitrile, methanol, THF, DCM, and supercritical CO₂-compatible co-solvents when used with optional 316L stainless steel pump heads. Its wetted path materials—316L SS plunger rods, sapphire check valves, and chemically resistant PEEK/PTFE seals—are compatible with pH 1–14 solvents and common cleaning agents (e.g., 10% nitric acid, 50% isopropanol). The pump meets CE electromagnetic compatibility (EMC) Directive 2014/30/EU and Low Voltage Directive 2014/35/EU. Its firmware architecture supports GLP/GMP audit trails, electronic signatures, and time-stamped event logging required for regulated pharmaceutical purification processes.
Software & Data Management
The SP1020 operates independently via its front-panel interface or integrates into networked lab environments through ASCII-based command sets documented in the publicly available communication protocol manual. When connected to a host PC, it supports real-time parameter monitoring—including instantaneous flow rate, system pressure, motor temperature, and error codes—with timestamped CSV export. All configuration changes, method recalls, and emergency stop events are logged with ISO 8601 timestamps and user ID attribution, satisfying FDA 21 CFR Part 11 requirements for electronic records and signatures. No proprietary runtime environment or license keys are required for basic remote operation.
Applications
- Preparative reversed-phase and normal-phase HPLC purification of synthetic intermediates, natural products, and oligonucleotides.
- Automated flash chromatography systems for parallel compound library purification in medicinal chemistry labs.
- Continuous-flow synthesis support where precise reagent stoichiometry and residence time control are critical.
- Method transfer from analytical to preparative scale using identical gradient profiles and dwell volume compensation.
- Integration into PAT (Process Analytical Technology) workflows for real-time solvent delivery validation during GMP manufacturing.
FAQ
What is the maximum recommended operating pressure for continuous use?
The SP1020 is rated for continuous operation at ≤20 MPa with 316L stainless steel pump heads; pressure derating is advised above 18 MPa for extended seal life.
Does the pump support gradient mixing internally?
No—the SP1020 is a single-channel high-pressure pump; gradient formation requires external low-pressure mixing modules or dual-pump configurations.
Is flow calibration traceable to NIST standards?
Yes—calibration certificates include reference to gravimetric flow verification against NIST-traceable primary standards per ISO/IEC 17025 accredited procedures.
Can the pump be operated in constant pressure mode?
No—it operates exclusively in constant flow mode; pressure is monitored but not actively regulated.
What maintenance intervals are recommended for routine operation?
Plunger seals should be inspected every 500 hours of operation; check valves require replacement every 2,000 hours under typical organic solvent usage.
