Sartorius Cubis II Semi-Micro / High-Capacity Micro Balance
| Brand | Sartorius |
|---|---|
| Origin | Shanghai, China |
| Manufacturer Type | Authorized Distributor |
| Product Category | Domestic (China-manufactured) |
| Model | MCE/MCA-3CCN |
| Instrument Type | Analytical Balance |
| Calibration | Automatic |
| Maximum Capacity | 220 g |
| Readability | 10 µg / 1 µg |
Overview
The Sartorius Cubis II Semi-Micro / High-Capacity Micro Balance is an advanced analytical balance engineered for precision, stability, and regulatory compliance in regulated laboratory environments. Built upon the fourth-generation SuperMonoCell weighing system, it delivers ultra-fast stabilization—typically under 2 seconds—even under dynamic ambient conditions including temperature fluctuations, humidity shifts, barometric pressure changes, and electrostatic interference. Its core measurement principle relies on electromagnetic force compensation (EMFC), where the restoring force required to maintain zero displacement of the weighing pan is precisely measured and converted into mass with traceable metrological integrity. Designed for dual operational modes—semi-micro (up to 220 g at 10 µg readability) and high-capacity micro (down to 1 µg readability on select configurations)—this balance bridges the gap between routine analytical weighing and ultra-low-mass critical applications such as reference standard preparation, potency assay formulation, and nanogram-level sample handling in pharmaceutical QC, biopharmaceutical development, medical device testing, and environmental analysis.
Key Features
- Ultra-stable SuperMonoCell weighing sensor with integrated temperature and pressure compensation algorithms
- 100% electrostatic neutralization via four strategically positioned ionizing nozzles and conductive coating on draft shield components
- Intelligent environmental adaptation: real-time self-adjustment to ambient temperature, relative humidity, and air pressure gradients
- Tool-free modular design enabling rapid disassembly of draft shields, weighing pans, and base plates for cleaning and maintenance
- Chemical-resistant housing materials compliant with ISO 8573-1 Class 3 for particulate and oil vapor resistance
- QApp-enabled guided cleaning workflows with step-by-step visual instructions and embedded audit trail generation
- Scalable hardware architecture supporting post-purchase integration of motorized draft shields, internal ionizers, climate sensors, and vibration isolation modules
Sample Compatibility & Compliance
The Cubis II MCA-3CCN supports a broad range of sample types—from volatile solvents and hygroscopic powders to static-prone polymers and low-mass reference standards—without compromising repeatability or linearity. Its draft shield design minimizes convective airflow while maintaining ergonomic access. All models are designed and verified to meet ISO/IEC 17025:2017 requirements for calibration laboratories and support full traceability per ISO 9001, ISO/IEC 17025, and USP . The balance is fully compatible with Good Manufacturing Practice (GMP) and Good Laboratory Practice (GLP) workflows, featuring built-in electronic signatures, user role-based access control, and tamper-evident audit logs compliant with FDA 21 CFR Part 11 and EU Annex 11.
Software & Data Management
Equipped with the MCA touchscreen interface and embedded QApps, the Cubis II enables seamless digital integration without middleware dependency. It supports direct export of weight data—including timestamps, operator ID, balance status, and environmental metadata—to LIMS, ELN, or ERP systems via Ethernet, USB, or RS-232. The Ingenix Suite provides centralized fleet management, remote firmware updates, and automated report generation aligned with ALCOA+ principles (Attributable, Legible, Contemporaneous, Original, Accurate, Complete, Consistent, Enduring, Available). Each software license is perpetual and application-specific, eliminating recurring subscription fees or annual maintenance contracts.
Applications
- Preparation and verification of certified reference materials (CRMs) and pharmacopeial standards
- Weighing of active pharmaceutical ingredients (APIs) during formulation development and batch release testing
- Gravimetric analysis of residual solvents, extractables, and leachables in packaging validation studies
- Low-mass calibration of pipettes, syringes, and microfluidic devices using gravimetric methods per ISO 8655
- Environmental monitoring of airborne particulates and filter-based mass loading protocols (e.g., EPA Method 201A)
- Research-scale synthesis requiring precise stoichiometric reagent dosing below 1 mg
FAQ
What is the minimum sample weight supported by the MCA-3CCN configuration?
The minimum weighable quantity (MWQ) is determined by the readability and repeatability performance; for the 10 µg readability mode, MWQ is typically ≥20 mg under GLP-compliant conditions.
Does the balance support internal calibration with external weights?
Yes—it supports both automatic internal calibration (via built-in mass standard) and manual external calibration using certified weights traceable to NIST or equivalent national metrology institutes.
Can the Cubis II be integrated into a validated computerized system?
Yes—the MCA platform includes full 21 CFR Part 11 technical controls: electronic signatures, audit trail with immutable records, and configurable user permissions—all implemented at firmware level without third-party add-ons.
Is climate compensation available as a factory-installed option?
Climate compensation (temperature, humidity, pressure) is embedded in all Cubis II MCA models and operates continuously without requiring optional hardware.
How does the QApp-guided cleaning process ensure compliance?
Each cleaning session generates a timestamped, user-verified log entry containing executed steps, duration, and component status—exportable as PDF or CSV for inclusion in SOP documentation and regulatory submissions.
