Thermo Fisher Dionex AS-DV Automated Sample Injector
| Brand | Thermo Fisher |
|---|---|
| Origin | Canada |
| Manufacturer Type | Authorized Distributor |
| Origin Category | Imported |
| Model | AS-DV |
| Price Range | USD 1,400–7,000 (FOB) |
| Product Category | Chromatography |
| Operational Age | 3–4 years |
| Warranty | 6 months |
Overview
The Thermo Fisher Dionex AS-DV Automated Sample Injector is a precision-engineered autosampler designed specifically for integration with Thermo Scientific Dionex ion chromatography (IC) systems. It operates on a robust syringe-driven, positive-displacement sampling principle—ensuring high volumetric accuracy and minimal carryover across repeated injections. Unlike pressure-driven or loop-based injectors, the AS-DV employs a dual-piston, PEEK-fluidic architecture to deliver precise sample aspiration, metering, and injection into the IC flow path. Its core function supports both full-loop injection and concentrator-column loading protocols, making it indispensable for trace anion/cation analysis in environmental, pharmaceutical, and food safety laboratories where low detection limits and regulatory compliance are critical.
Key Features
- Full-liquid-fill and concentrator-column loading modes programmable via Chromeleon CDS software
- PEEK-wetted fluid path—including syringe, needle, and valve rotor—ensuring chemical inertness and compatibility with aggressive eluents (e.g., KOH, methanesulfonic acid)
- Support for optional 6-port or 10-port switching valves to automate matrix elimination, online dilution, and pre-concentration workflows
- Random-access sample positioning with independent vial tray indexing—enabling non-sequential injection sequences without mechanical repositioning delay
- Dual-IC system capability: simultaneous sample delivery to two separate Dionex IC instruments using shared tray and valve logic
- Integrated audit trail and operational logging compliant with GLP/GMP documentation requirements
- Carryover < 0.01% (measured with 100 ppm chloride standard), validated per ASTM D4327 and ISO 14911
Sample Compatibility & Compliance
The AS-DV accepts standard Dionex-compatible polymer vials (0.5 mL and 5.0 mL formats), including those fitted with optional filtration caps for particulate removal prior to injection. It maintains full interoperability with all Dionex ICS-1000, ICS-1100, ICS-1600, ICS-2000, and ICS-5000+ platforms. The instrument meets essential regulatory design criteria for analytical instrumentation used in FDA-regulated environments: its firmware supports user access levels, electronic signatures, and 21 CFR Part 11–compliant audit trails when deployed with Chromeleon 7.2.8 or later. All hardware components comply with RoHS directives and CE marking requirements for laboratory equipment placed on EEA markets.
Software & Data Management
Controlled exclusively through Thermo Scientific Chromeleon Chromatography Data System (CDS) v7.x, the AS-DV leverages native driver integration for seamless method development, sequence definition, and real-time status monitoring. Chromeleon provides comprehensive reporting modules—including injection log export (CSV/Excel), system suitability summaries, and automated pass/fail evaluation against user-defined acceptance criteria. Audit trail records capture operator ID, timestamp, parameter changes, and injection events with immutable hashing—fully traceable during internal QA audits or external inspections by Health Canada, EMA, or USP. Remote diagnostics and firmware updates are supported via secure HTTPS-enabled Chromeleon Server deployment.
Applications
The AS-DV is routinely deployed in laboratories performing regulated ion analysis under USP , EPA Methods 300.0/300.1, ASTM D4327 (anions in water), and ISO 14911 (cation analysis in beverages). Its concentrator-column mode enables sub-pptr detection of fluoride, nitrate, and sulfate in drinking water matrices; its matrix-clearance capability supports direct injection of undiluted wine, dairy, or biological fluids without manual pretreatment. In QC environments, the instrument’s reproducible 1–100 µL injection range (±0.5% RSD, n=10) ensures batch-to-batch consistency for release testing of excipients and active pharmaceutical ingredients per ICH Q2(R2) guidelines.
FAQ
Is the AS-DV compatible with non-Dionex IC systems?
No—it requires native firmware and electrical interface alignment with Thermo Fisher Dionex IC controllers and cannot be retrofitted for use with third-party or legacy HPLC platforms.
What validation documentation is included with refurbished units?
Each unit ships with a Certificate of Operational Verification (COV), including performance test data for injection precision, carryover, linearity (5–100 µL), and valve switching repeatability—performed per IQ/OQ protocol aligned with ISO/IEC 17025.
Can the AS-DV operate unattended overnight?
Yes—when paired with Chromeleon CDS scheduler and uninterruptible power supply (UPS), it supports fully automated 24-hour sequencing with email alerts triggered by error conditions or completion events.
Does the 6-month warranty cover valve actuation cycles and syringe wear?
Yes—the warranty includes functional coverage of all electromechanical subsystems, including stepper motor actuators, syringe plunger seals, and rotary valve stators, subject to documented usage logs.
Is Chromeleon CDS software included with the instrument?
No—Chromeleon must be licensed separately; however, basic operation mode (manual injection, single-sequence execution) is accessible without full license activation.
