Thermo Fisher Orbitrap Exploris 480 High-Resolution Mass Spectrometer (Rental Unit)
| Brand | Thermo Fisher |
|---|---|
| Origin | USA |
| Manufacturer Status | Authorized Distributor |
| Origin Category | Imported |
| Model | Orbitrap Exploris 480 |
| Pricing | Available Upon Request |
Overview
The Thermo Scientific™ Orbitrap Exploris 480 is a high-resolution, accurate-mass (HRAM) hybrid quadrupole-Orbitrap mass spectrometer engineered for demanding proteomics, biopharmaceutical characterization, and quantitative omics workflows. It operates on the principle of electrostatic trapping and Fourier-transform ion cyclotron resonance–inspired detection within the Orbitrap analyzer—delivering ultra-high mass resolution, sub-ppm mass accuracy, and exceptional dynamic range without routine recalibration. Designed for robust daily operation in core facilities and regulated environments, the system integrates seamlessly with UHPLC platforms to support both data-dependent acquisition (DDA) and data-independent acquisition (DIA), including label-free quantitation (LFQ), TMT, and SWATH. Its compact footprint (≤1.2 m² floor space) addresses spatial constraints common in modern analytical laboratories while maintaining full analytical capability.
Key Features
- Orbitrap mass analyzer with up to 480,000 resolution at m/z 200, enabling confident identification and quantification in highly complex biological matrices
- Mass accuracy <3 ppm RMS over 24 hours without intermediate recalibration—critical for longitudinal studies and regulatory submissions
- Dynamic range >5000:1 in a single full-scan Orbitrap spectrum, supporting co-detection of low- and high-abundance analytes
- Mass range 40–8000 m/z, accommodating intact proteins, large peptides, glycans, and small-molecule metabolites
- Fast polarity switching (<1 s per full cycle: positive + negative mode scans at R=60,000), ideal for untargeted screening
- Up to 40 Hz scan rate at R=7,500 (at m/z 200), ensuring high chromatographic fidelity in UHPLC applications
- Dual analog input channels (0–1 V and 0–10 V) for synchronized external device triggering and signal monitoring
- Integrated vacuum architecture with optimized pumping stages for rapid pump-down and long-term stability
Sample Compatibility & Compliance
The Orbitrap Exploris 480 supports direct coupling to nano-, micro-, and analytical-flow LC systems—including Thermo Scientific Vanquish UHPLC—and accommodates electrospray ionization (ESI), heated electrospray ionization (H-ESI), and optional atmospheric pressure chemical ionization (APCI). It is routinely deployed in GLP-compliant bioanalytical labs and GMP-aligned biopharma QC environments. The instrument’s firmware and software architecture comply with 21 CFR Part 11 requirements for electronic records and signatures when configured with audit trail, user access controls, and secure data archiving. Method validation workflows align with ICH Q2(R2), USP <1225>, and ISO/IEC 17025 standards for method performance verification.
Software & Data Management
Controlled via Thermo Scientific™ Tune and Compound Discoverer 3.3 or later, the system supports automated calibration, method templating, and real-time spectral quality assessment. Raw data files (.raw) are natively compatible with Proteome Discoverer 2.5+ for bottom-up proteomics, as well as third-party platforms including Skyline, MaxQuant, and Spectronaut. All software modules include configurable audit trails, version-controlled method storage, and role-based permissions—enabling traceable, reproducible operations across multi-user facilities. Data integrity is reinforced through automatic checksum generation, write-once-read-many (WORM) archival options, and integration with LIMS via standard API protocols.
Applications
- Deep proteome profiling with >10,000 protein group identifications per run in human cell lysates
- Intact mass analysis of monoclonal antibodies (mAbs) and antibody-drug conjugates (ADCs) up to 150 kDa
- Post-translational modification (PTM) mapping—including phosphorylation, glycosylation, and ubiquitination—with site-localization confidence scoring
- Metabolite identification and semi-quantitative screening in plasma, urine, and tissue extracts
- Comparative biopharma analytics: higher-order structure assessment via native MS, charge variant profiling, and forced degradation product characterization
- Environmental and food safety screening for trace-level contaminants (e.g., mycotoxins, pesticides) using suspect- and non-targeted workflows
FAQ
What rental terms are available for the Orbitrap Exploris 480?
Short-term leases (1–6 months), rent-to-own agreements (12–36 months), and capital lease structures with title transfer at term end are offered—each with flexible start dates and installation scheduling.
Is method transfer support included?
Yes—on-site application training, method optimization assistance, and documentation of instrument qualification (IQ/OQ) are provided as part of standard rental packages.
Can the system be integrated into an existing LIMS or ELN environment?
All Thermo Scientific instruments support ASTM E1384-compliant data export and offer RESTful APIs for bidirectional integration with major laboratory informatics platforms.
What maintenance and service coverage is included during the lease period?
Comprehensive service plans include preventive maintenance, remote diagnostics, priority response SLAs, and guaranteed uptime contracts—fully aligned with ISO 9001-certified field service operations.
Are consumables and spare parts supplied under the rental agreement?
Standard consumables (ion transfer tubes, source components, calibration solutions) are available via optional replenishment programs; critical spares are maintained on-site or regionally for rapid deployment.
