Ultrafiltration Membrane System XBL-UF Series by New Biolink
| Brand | New Biolink |
|---|---|
| Model | XBL-UF Series |
| Origin | Beijing, China |
| Membrane Configuration Options | Hollow Fiber, Spiral-Wound, Tubular, Flat Sheet |
| Operating Pressure Range | 0.03–1.2 MPa |
| Molecular Weight Cut-Off (MWCO) | 1,000–500,000 Da |
| Primary Application | Wastewater Treatment, Process Stream Clarification, Biomolecule Separation |
| Compliance | Designed for GLP-compliant labs |
Overview
The New Biolink XBL-UF Series Ultrafiltration Membrane System is an engineered benchtop or pilot-scale solution for pressure-driven liquid separation based on size-exclusion principles. It operates via tangential or dead-end filtration across semi-permeable polymeric or ceramic membranes, utilizing transmembrane pressure differentials to selectively retain macromolecules, colloids, microorganisms, and particulates while permitting passage of water, salts, and low-molecular-weight solutes. With nominal molecular weight cut-offs (MWCO) ranging from 1,000 to 500,000 Da and operational pressures spanning 0.03–1.2 MPa, the system supports reproducible fractionation of complex aqueous streams—including industrial wastewater, fermentation broths, protein solutions, and potable water sources—without phase change or chemical addition. Its modular architecture enables integration into multi-step purification workflows, serving as both a standalone unit and a pre-treatment stage upstream of reverse osmosis (RO) or ion exchange systems.
Key Features
- Interchangeable membrane module support: accommodates hollow fiber, spiral-wound, tubular, and flat-sheet configurations—enabling method development across feed viscosity, fouling propensity, and throughput requirements
- Stainless steel 316L housing with sanitary tri-clamp connections (ISO 2852) and integrated pressure gauges at feed, retentate, and permeate ports
- Variable-speed diaphragm or centrifugal feed pump with digital flow control (0.5–20 L/min range), ensuring stable crossflow velocity and minimized concentration polarization
- Temperature-stable operation (5–40 °C) with optional jacketed vessels for process-critical thermal management
- Pre-calibrated transmembrane pressure (TMP) monitoring and automated backpulse cleaning cycles (optional) to extend membrane service life and maintain flux stability
- CE-marked electrical cabinet with IP54 enclosure, emergency stop, and overload protection compliant with IEC 61000-6-2/6-4 EMC standards
Sample Compatibility & Compliance
The XBL-UF Series processes aqueous feed streams with total suspended solids (TSS) ≤ 100 mg/L and turbidity ≤ 50 NTU without mandatory pre-filtration. It is validated for use with pharmaceutical process water (PW), purified water (PW), and water for injection (WFI) polishing per USP , supporting endotoxin reduction ≥ 3-log₁₀ in compliance with FDA guidance for biologics manufacturing. The system meets material compatibility requirements outlined in EP 2.2.58 and ASTM D4189 for membrane integrity testing. All wetted components conform to FDA 21 CFR Part 177 for indirect food additives, and documentation packages include membrane lot traceability, extractables profiles, and sterilization validation summaries (SIP at 121 °C for 30 min).
Software & Data Management
Equipped with a 7-inch touchscreen HMI running embedded Linux OS, the system logs real-time parameters—including TMP, permeate flux, cumulative volume, temperature, and differential pressure—into timestamped CSV files exportable via USB or Ethernet. Audit trail functionality complies with FDA 21 CFR Part 11 requirements, including user authentication, electronic signatures, and immutable record retention for ≥ 12 months. Optional LabVIEW™ or OPC UA integration enables centralized SCADA connectivity for GMP environments requiring full data lineage and electronic batch record (EBR) synchronization.
Applications
- Removal of pyrogens and aggregates from monoclonal antibody formulations during downstream processing
- Clarification and diafiltration of microbial fermentation supernatants prior to chromatographic capture
- Recovery and concentration of enzymes, vaccines, and viral vectors with minimal activity loss
- Treatment of municipal and industrial wastewater to meet discharge limits per ISO 15839 and local regulatory thresholds
- Polishing of natural mineral water to achieve microbiological safety (≤1 CFU/100 mL) without chlorine or UV residuals
- Pre-filtration protection for RO membranes in zero-liquid-discharge (ZLD) systems
FAQ
What membrane materials are supported by the XBL-UF Series?
Polyethersulfone (PES), polyvinylidene fluoride (PVDF), regenerated cellulose (RC), and alumina-based ceramic membranes—each available in standardized MWCO grades.
Can the system be validated for GMP production use?
Yes. IQ/OQ documentation templates, membrane integrity test protocols (e.g., pressure hold, diffusion test), and calibration certificates for all critical sensors are provided upon request.
Is remote monitoring capability available?
Standard Ethernet port supports Modbus TCP and optional MQTT integration for cloud-based telemetry and predictive maintenance alerts.
What is the typical service life of ultrafiltration membranes under continuous operation?
With proper CIP/SIP regimens and feed pretreatment, PES and PVDF membranes demonstrate >12 months of stable performance in well-characterized bioprocess streams.
Does the system include cleaning-in-place (CIP) functionality?
A dedicated CIP loop with dual-directional recirculation, heated chemical dosing, and conductivity-based endpoint detection is available as an upgrade option.
