Waters ACQUITY UPLC I-Class PLUS Liquid Chromatography System (Rental Unit)
| Brand | Waters |
|---|---|
| Origin | USA |
| Manufacturer Type | Authorized Distributor |
| Product Origin | Imported |
| Model | ACQUITY UPLC I-Class PLUS |
| Pricing | Available Upon Request |
Overview
The Waters ACQUITY UPLC I-Class PLUS is a high-performance, modular ultra-high performance liquid chromatography (UHPLC) system engineered for precision, reproducibility, and seamless integration with mass spectrometry (MS) platforms. Leveraging advanced low-diffusion fluidics architecture and sub-2 µm particle chromatography, it delivers exceptional peak capacity, resolution, and sensitivity—enabling robust method development, transfer, and routine analysis in regulated and research environments. Its core design emphasizes minimal system dwell volume (<100 µL), ultra-low carryover (<0.001% caffeine), and thermally stabilized flow paths to ensure retention time stability and quantitative accuracy across diverse sample matrices. The system operates at pressures up to 137 MPa (18,000 psi), supporting high-efficiency separations on columns ranging from 1.0 mm to 4.6 mm internal diameter and up to 150 mm in length.
Key Features
- Binary Solvent Manager (BSM) with active solvent pre-heating and integrated solvent selection valve for precise gradient formation using up to four mobile phases
- Sample Manager with Flow-Through Needle (SM-FTN) or Fixed Loop injection options, configurable for universal compatibility with vials, plates, and automated sample handling
- Column Heater/Chiller (CHA) with active pre-heating and dual-column capability (1–2 columns), maintaining temperature control from 4 °C to 40 °C with ±0.5 °C accuracy
- eCord™ technology for automatic column tracking—recording and archiving column identity, usage history, pressure profiles, and maintenance logs
- Low-volume, stainless-steel fluidic path optimized for UV, PDA, and TUV detection; compatible with electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) sources
- Empower 3 Chromatography Data System (CDS) support with built-in System Suitability Testing (SST), audit trail, and 21 CFR Part 11 compliance modules
Sample Compatibility & Compliance
The ACQUITY UPLC I-Class PLUS accommodates a broad range of sample types—including small molecules, peptides, oligonucleotides, and polar metabolites—across pH 1–12.5 mobile phase conditions. Its inert stainless-steel flow path minimizes adsorption and degradation of labile analytes. The system meets critical regulatory requirements for pharmaceutical, biotech, and clinical laboratories: fully compliant with USP <621>, ICH Q2(R2), ASTM E2639, and ISO/IEC 17025 quality management frameworks. When deployed with Empower 3 and enabled audit trail, electronic signatures, and instrument qualification templates (SQT), it supports GLP/GMP workflows and FDA inspection readiness.
Software & Data Management
Empower 3 software serves as the central platform for method development, acquisition, processing, reporting, and system qualification. It provides automated system suitability testing, customizable report templates, and secure user role management. All instrument events—including method changes, calibration updates, and maintenance interventions—are captured in a tamper-evident audit trail. Data integrity is reinforced through encrypted storage, version-controlled methods, and electronic signature workflows aligned with 21 CFR Part 11 and Annex 11 requirements. Remote monitoring and centralized deployment options enable enterprise-scale deployment across multi-site laboratories.
Applications
This UPLC system is routinely deployed in pharmaceutical QC/QA for assay validation, impurity profiling, and stability-indicating methods; in biopharma for peptide mapping, mAb characterization, and glycan analysis; and in academic and government labs for environmental contaminant screening, food safety testing, and forensic toxicology. Its high-resolution capabilities significantly reduce co-elution artifacts in complex biological matrices, enhancing confidence in MS/MS spectral interpretation and quantification accuracy. Method transfer from HPLC to UPLC is streamlined via embedded scalability tools within Empower.
FAQ
What rental terms are available for the ACQUITY UPLC I-Class PLUS?
Short-term lease (1–6 months), lease-to-own (12–36 months with purchase option), and finance lease (full ownership transfer upon term completion) are offered.
Is installation and qualification included in the rental package?
Yes—Waters-certified engineers perform on-site installation, operational qualification (OQ), and performance qualification (PQ) per IQ/OQ/PQ protocols; documentation is provided in English and compliant with GxP standards.
Can the system be integrated with existing laboratory informatics infrastructure?
Yes—it supports LIMS connectivity via standard APIs, CSV/Excel export, and direct Empower-to-ELN integration using Waters’ Open Access or third-party middleware.
Are consumables and service support included during the lease period?
Consumables are billed separately; however, comprehensive service contracts—including preventive maintenance, remote diagnostics, and priority response—can be bundled upon request.
Does the rental unit include full Empower 3 licensing?
Yes—each unit ships with a validated, multi-user Empower 3 license (5 concurrent users), including all CDS modules, SQT, and 21 CFR Part 11 compliance features.
