Waters Xevo G2-XS QTof High-Resolution Quadrupole Time-of-Flight Mass Spectrometer (Refurbished)
| Brand | Waters |
|---|---|
| Origin | USA |
| Model | Xevo G2-XS QTof |
| Mass Range | 20–16,000 m/z |
| Resolution | >40,000 FWHM (at m/z 556) |
| TOF Mass Range | >100,000 m/z |
| Mass Accuracy | <1 ppm (external calibration) |
| Acquisition Rate | ≥30 spectra/sec |
| Detector | 6 GHz digitizer with 5-decade linear dynamic range |
| Instrument Age | 4 years |
| Warranty | 12 months |
Overview
The Waters Xevo G2-XS QTof is a high-performance, quadrupole time-of-flight (Q-TOF) mass spectrometer engineered for untargeted and targeted analysis of complex biological, pharmaceutical, environmental, and chemical matrices. Combining a robust RF-only quadrupole ion guide with orthogonal acceleration TOF technology, the system delivers high mass accuracy, exceptional resolution, and rapid spectral acquisition—enabling confident compound identification, structural elucidation, and precise relative or absolute quantitation. This refurbished unit has undergone full functional validation at SpectraLab Scientific Inc., including vacuum integrity verification, mass calibration stability assessment, sensitivity profiling across multiple reference compounds (e.g., reserpine, leucine enkephalin), and chromatographic integration testing with an ACQUITY UPLC platform. All subsystems—including the electrospray ionization (ESI) source, collision cell, reflectron optics, and time-to-digital converter—are verified to meet original factory specifications.
Key Features
- High-resolution Q-TOF architecture delivering >40,000 FWHM resolution at m/z 556, enabling separation of isobaric species and accurate elemental composition determination.
- Mass measurement accuracy <1 ppm using external calibration, supporting compliance with regulatory requirements for identity confirmation (e.g., ICH M7, USP <1225>).
- Wide mass range spanning 20–16,000 m/z in MS mode and >100,000 m/z in TOF-only mode, facilitating analysis of small molecules, peptides, oligonucleotides, and intact proteins.
- 6 GHz high-speed digitizer with five-decade linear dynamic range ensures quantitative linearity across three orders of magnitude without signal saturation or detector dead-time artifacts.
- Integrated ACQUITY UPLC platform—including Sample Manager, Column Manager, and H-Class Quaternary Solvent Manager—optimized for sub-2 µm particle column operation and low dispersion flow paths.
- Full-system refurbishment includes replacement of critical consumables (ion transfer optics, detector components, ESI capillaries), recalibration of all voltage rails, and firmware updated to latest stable release (MassLynx v4.2 or later).
Sample Compatibility & Compliance
The Xevo G2-XS QTof supports electrospray ionization (ESI), atmospheric pressure chemical ionization (APCI), and optional sources such as DESI and nano-ESI. It is routinely deployed in GLP-compliant laboratories for metabolite identification, impurity profiling, and biopharmaceutical characterization. The instrument meets key analytical standards including ASTM E2968-14 (mass accuracy validation), ISO/IEC 17025:2017 (method validation requirements), and supports 21 CFR Part 11 compliance when paired with MassLynx software configured with audit trail, electronic signatures, and user access controls. All refurbished units undergo IQ/OQ documentation per vendor-recommended protocols and are supplied with a complete validation summary report.
Software & Data Management
Controlled via Waters MassLynx v4.2 or higher, the system provides comprehensive data acquisition, processing, and reporting capabilities. Key modules include TargetLynx for quantitative workflows, UNIFI for regulated environments (supporting audit trail, electronic signatures, and workflow-based review), and ProteinLynx Global SERVER (PLGS) for proteomics. Raw data files (.raw) are fully compatible with third-party open-source tools (e.g., Skyline, OpenMS, MS-DIAL) and commercial platforms (e.g., Compound Discoverer, SimGlycan). Data storage follows FAIR principles—metadata-rich .raw files include full instrument method parameters, calibration history, and acquisition timestamps.
Applications
- Non-targeted metabolomics and lipidomics in human plasma, urine, and tissue extracts.
- Peptide mapping and post-translational modification (PTM) analysis of monoclonal antibodies and biosimilars.
- Residual solvent and genotoxic impurity screening per ICH Q3C/Q3D guidelines.
- Environmental contaminant identification (e.g., PFAS, microplastics degradation products) in water and soil extracts.
- Forensic toxicology screening with retrospective data mining using MSE and HDMSE acquisition modes.
- Reaction monitoring in synthetic chemistry via real-time infusion or LC-coupled workflows.
FAQ
Is this instrument eligible for extended warranty or service contracts?
Yes—eligible customers may purchase Waters Service Agreements (including PlatinumCare) directly through authorized partners; coverage includes preventive maintenance, priority remote support, and on-site engineer dispatch.
Does the refurbishment include source cleaning and ion optic replacement?
Yes—each unit receives full disassembly and ultrasonic cleaning of the ESI source, replacement of all high-voltage ion optics (quadrupole rods, pusher plates, reflectron electrodes), and detector gain calibration.
Can the system be validated for GMP use?
Yes—documentation packages (IQ/OQ/PQ templates, calibration records, and test reports) are provided. Optional qualification support is available upon request.
What LC systems are compatible beyond ACQUITY UPLC?
The Xevo G2-XS QTof interfaces seamlessly with Thermo Vanquish, Agilent 1290, and Shimadzu Nexera UHPLC systems via standard analog/digital I/O and MassLynx LC control drivers.
Are software licenses included with the refurbished system?
Yes—the unit ships with perpetual MassLynx and UNIFI licenses (with active maintenance until date of sale); renewal options are available post-purchase.
