Xiangyi CH260R High-Capacity High-Speed Refrigerated Centrifuge

Overview

The Xiangyi CH260R is a floor-standing, high-capacity, refrigerated high-speed centrifuge engineered for reproducible separation of biological macromolecules—including nucleic acids, proteins, organelles, viruses, and subcellular particles—under precisely controlled thermal conditions. Operating on the principle of sedimentation velocity centrifugation, the CH260R utilizes high angular velocity to generate radial forces up to 80,035 × g, enabling rapid pelleting and density-gradient fractionation of heterogeneous samples. Its integrated refrigeration system maintains sample temperature between –20 °C and +40 °C with ±1 °C accuracy across the full speed range, mitigating thermal denaturation during extended runs. Designed for sustained duty cycles in core facilities and industrial QC labs, the CH260R features a rigid cast-iron base, active rotor imbalance detection, and brushless frequency-controlled drive technology for long-term mechanical stability and low-vibration operation.

Key Features

• High-capacity horizontal swing-out rotor configuration supporting six 1000 mL bottles—optimized for large-volume cell harvests, fermentation broths, and bioprocess intermediates.
• Intelligent centrifuge management system with pre-programmed application-specific protocols (e.g., “Virus Pellet”, “Mitochondrial Isolation”, “Plasmid DNA Prep”) reducing operator dependency and inter-run variability.
• Real-time RCF monitoring and automatic speed-to-RCF conversion; all parameters displayed on a 7-inch capacitive touchscreen with multi-language UI support (English, German, French, Spanish).
• Dual-stage refrigeration with independent condenser cooling and optimized airflow channels ensures rapid cooldown (<15 min from 25 °C to –20 °C) and minimal temperature overshoot during acceleration.
• Comprehensive safety architecture: automatic lid lock with force-sensing interlock, rotor recognition via RFID tags, emergency deceleration (<2 min from 26,000 rpm to rest), and ISO 22810-compliant acoustic noise reduction (<58 dB[A] at 1 m).
• Modular rotor library supporting up to 16 certified configurations—including fixed-angle, horizontal, and continuous-flow rotors—for applications ranging from low-speed clarification (e.g., whole blood) to ultracentrifugal purification (e.g., exosomes).

Sample Compatibility & Compliance

The CH260R accommodates standard laboratory containers including polypropylene and polycarbonate bottles (up to 1000 mL), conical tubes (15–50 mL), and custom adapters for microtiter plates and cryovials. All rotors are validated per ISO 15189 Annex A.3 (Centrifuge Performance Verification) and comply with IEC 61010-2-020 for safety in laboratory equipment. The system supports GLP/GMP-aligned workflows through audit-trail-enabled user authentication, session logging, and electronic signature capability—fully compatible with FDA 21 CFR Part 11 requirements when deployed with validated LIMS integration. Routine calibration certificates (speed, temperature, RCF) are traceable to NIM (National Institute of Metrology, China) standards.

Software & Data Management

Xiangyi CentriControl™ v3.2 software provides local and networked control via Ethernet or optional Wi-Fi module. It enables method transfer across instruments, batch run scheduling, remote status monitoring, and export of raw data in CSV and XML formats compliant with ASTM E2500-17 (Standard Guide for Specification, Design, and Verification of Pharmaceutical and Biopharmaceutical Manufacturing Systems). Audit trails record operator ID, timestamp, parameter changes, and error events with immutable hashing. Data integrity is reinforced by role-based access control (RBAC), encrypted local storage, and optional cloud backup with TLS 1.3 encryption.

Applications

• Molecular biology: Large-scale plasmid DNA isolation, ribosome purification, and RNA extraction from tissue homogenates.
• Virology & vaccine development: Concentration of lentiviral vectors, adenoviruses, and influenza HA antigens from bioreactor supernatants.
• Biopharmaceutical manufacturing: Clarification of monoclonal antibody harvests, removal of host cell proteins (HCP), and intermediate purification steps prior to chromatography.
• Clinical diagnostics: High-throughput serum/plasma separation for biomarker discovery and circulating tumor DNA (ctDNA) enrichment.
• Industrial microbiology: Harvesting of yeast, bacterial, and fungal biomass for enzyme production and metabolic engineering studies.

FAQ

What is the maximum allowable sample volume per run?
The CH260R supports up to 6 × 1000 mL in its standard horizontal rotor, yielding a total capacity of 6 L per run.
Does the system meet international regulatory requirements for GxP environments?
Yes—when configured with CentriControl™ v3.2 and validated procedures, it satisfies FDA 21 CFR Part 11, EU Annex 11, and ISO/IEC 17025 documentation requirements.
Can third-party rotors be used?
No—only Xiangyi-certified rotors with embedded RFID tags are recognized and enabled by the firmware to ensure mechanical integrity and safety compliance.
Is routine maintenance supported remotely?
Yes—embedded diagnostics report bearing health, refrigerant pressure, motor winding resistance, and vacuum seal integrity; alerts are routed via SNMP or email to designated service personnel.
What is the typical lead time for rotor qualification and method validation support?
Xiangyi’s Application Support Center provides documented rotor performance reports and SOP templates within 5 business days of order confirmation.