Xiangyi DL-6M Large-Capacity Low-Speed Refrigerated Centrifuge
| Brand | Xiangyi |
|---|---|
| Origin | Hunan, China |
| Manufacturer Type | Direct Manufacturer |
| Product Category | Domestic |
| Model | DL-6M |
| Instrument Type | Floor-Standing Centrifuge |
| Speed Range | Up to 6,000 rpm |
| Max RCF | 6,680 × g |
| Max Capacity | 6 × 1000 mL |
| Temperature Range | −20 °C to +40 °C (maintains ≤ −4 °C at max speed) |
| Acceleration/Deceleration | 9 acceleration steps, 10 deceleration steps |
| Drive System | Brushless Inverter Motor |
| Rotor Material | 7075-T6 Forged Aluminum Alloy, Hard-Anodized |
| Noise Level | < 65 dB(A) |
| Dimensions (W×D×H) | 730 × 840 × 1200 mm |
| Safety Compliance | Automatic imbalance detection, overspeed protection, overtemperature cutoff, interlocked door safety system |
| Construction | Full steel frame with triple-layer safety enclosure |
Overview
The Xiangyi DL-6M is a floor-standing, large-capacity low-speed refrigerated centrifuge engineered for high-reliability batch processing in biopharmaceutical manufacturing, blood banking, and cell biology laboratories. It operates on the principle of sedimentation-based separation under controlled low-speed rotational forces, optimized for pelleting large-volume suspensions of intact cells, organelles, viruses, and macromolecular complexes without shear-induced damage. With a maximum capacity of 6 × 1000 mL and a rated speed of 6,000 rpm (generating up to 6,680 × g), the DL-6M bridges the performance gap between standard preparative centrifuges and ultra-large-scale process equipment—enabling scalable workflows from pilot-scale purification to routine clinical specimen processing. Its integrated refrigeration system utilizes environmentally compliant refrigerants to maintain precise thermal control across the full operating range (−20 °C to +40 °C), ensuring sample integrity during extended runs—even at maximum rotor speed, where internal temperature remains below −4 °C.
Key Features
- Brushless inverter motor drive ensures consistent torque delivery, minimal maintenance, and long-term operational stability without carbon brush wear or commutator degradation.
- Triple-layer safety architecture includes a full steel monocoque chassis, reinforced rotor chamber shielding, and redundant electronic monitoring of mechanical and thermal parameters.
- Intelligent acceleration/deceleration profiling with 9 programmable ramp-up and 10 ramp-down steps allows users to optimize sedimentation kinetics for sensitive biological samples—reducing resuspension and improving pellet compactness.
- Touchscreen interface with real-time digital display provides intuitive access to run parameters, elapsed time, remaining time, temperature, and instantaneous RCF.
- Low-noise design (< 65 dB[A]) enables installation in shared laboratory environments without acoustic interference; vibration-damped suspension system minimizes structural transmission.
- Rotor and bucket assemblies fabricated from aerospace-grade 7075-T6 forged aluminum alloy, subjected to hard anodization for enhanced corrosion resistance and mechanical durability—each component traceable via certified material test reports (MTRs), non-destructive ultrasonic testing (UT), tensile strength verification, chemical composition analysis, and dimensional inspection records.
Sample Compatibility & Compliance
The DL-6M accommodates both round and square 1000 mL centrifuge buckets (6-position horizontal rotor configuration), supporting common disposable and reusable containers used in blood fractionation, vaccine production, and primary cell isolation protocols. Its design aligns with foundational requirements of Good Manufacturing Practice (GMP) and Good Laboratory Practice (GLP) frameworks—including mechanical stability under load, thermal uniformity across the chamber, and fail-safe interlocks for lid closure and rotor imbalance. While not certified to ISO 22870 or CLSI EP25-A2 by default, the instrument’s documented safety architecture, traceable material certifications, and programmable audit trails (via optional data export) support integration into regulated environments subject to FDA 21 CFR Part 11–compliant documentation workflows when paired with validated software interfaces.
Software & Data Management
The DL-6M operates via embedded firmware with no external PC dependency. All run parameters—including speed, time, temperature, acceleration/deceleration profiles, and cycle count—are stored internally with timestamping. Data export is supported through USB port (FAT32-formatted flash drives) in CSV format for post-run analysis in LIMS or statistical software. Optional firmware upgrades may extend connectivity to Ethernet-enabled lab networks for centralized monitoring, though native remote control or cloud synchronization is not implemented. Audit trail functionality includes automatic logging of parameter changes, door opening events, error codes, and emergency stop triggers—facilitating internal validation and regulatory review.
Applications
- Blood bank operations: Efficient separation of whole blood into packed red cells, platelet-rich plasma (PRP), and cryoprecipitate using standardized 1000 mL collection bags.
- Viral vector purification: Gentle pelleting of lentiviral or AAV particles from clarified harvest supernatants prior to density gradient or chromatographic refinement.
- Stem cell and primary tissue processing: Isolation of mesenchymal stromal cells (MSCs) or peripheral blood mononuclear cells (PBMCs) from large-volume leukapheresis products.
- Vaccine manufacturing: Clarification and concentration steps in bacterial antigen or inactivated virus production workflows.
- Industrial enzyme recovery: Harvesting microbial biomass from fermentation broths prior to lysis and downstream extraction.
FAQ
What is the minimum achievable temperature at maximum speed?
At 6,000 rpm, the chamber maintains ≤ −4 °C under standard ambient conditions (25 °C, 50% RH). Actual performance depends on room ventilation and initial sample temperature.
Is rotor balancing required before each run?
Yes—manual balance verification is mandatory per IEC 61010-2-020 requirements. The system detects gross imbalance but does not compensate for mass asymmetry; symmetrical loading of buckets is essential.
Can the DL-6M be validated for GMP use?
It supports IQ/OQ execution with vendor-provided documentation packages (e.g., factory calibration certificates, MTRs, UT reports); PQ must be performed in situ using user-defined acceptance criteria aligned with process requirements.
Are spare rotors and buckets available internationally?
Original-equipment 7075-T6 rotors and matching 1000 mL buckets are distributed globally through authorized Xiangyi partners; lead times vary by region and require advance ordering.
Does the unit comply with electromagnetic compatibility (EMC) standards?
It meets EN 61326-1:2013 for laboratory equipment emission and immunity, verified during CE marking procedures conducted in accordance with EU Directive 2014/30/EU.
