XIU LAB DB70-2A / IS70-2A / MIX200-4 Microplate Shaker Incubator

Overview

The XIU LAB DB70-2A, IS70-2A, and MIX200-4 Microplate Shaker Incubators are compact, benchtop instruments engineered for precise temperature-controlled shaking of microplates in life science laboratories. These units integrate Peltier-based or resistive heating with PID-controlled thermal regulation and digitally adjustable orbital shaking—enabling simultaneous incubation and mixing across 96-, 384-, and 1536-well formats. Designed for applications requiring strict thermal consistency and mechanical reproducibility—including enzyme kinetics, cell-based assays, immunoassays (ELISA), bacterial growth studies, and nucleic acid hybridization—the series delivers uniform temperature distribution (< ±0.3 °C) and stable setpoint maintenance under dynamic load conditions. Each model complies with IEC 61010-1 safety standards for laboratory equipment and features a thermally insulated chamber with low thermal inertia, ensuring rapid equilibration (≤20 min to reach 37 °C from ambient) and minimal overshoot.

Key Features

• PID-controlled temperature system with high-resolution (0.1 °C) digital display and real-time feedback loop for stability ≤ ±0.3 °C
• Adjustable orbital shaking: DB70-2A (100–1200 rpm, 2 mm orbit), IS70-2A (0–1500 rpm, 3 mm orbit), MIX200-4 (200–1000 rpm, 3 mm orbit), all with speed accuracy ±10 rpm
• Multi-format compatibility: accommodates up to four standard microplates (SBS-compliant) simultaneously; plate holders feature non-slip silicone grips and alignment guides
• Programmable timer (1 min – 99 h 59 min) with auto-shutdown and audible end-of-cycle alert
• Robust aluminum-alloy housing with front-access ventilation and overtemperature protection circuitry
• Universal power input (AC 100–230 V, 50–60 Hz) enabling global deployment without voltage conversion

Sample Compatibility & Compliance

These shaker incubators support standard ANSI/SBS microplates (96-, 384-, and 1536-well), PCR plates, deep-well blocks, and custom plate carriers with compatible footprint dimensions. Chamber geometry ensures unobstructed airflow and minimal thermal gradient across stacked plates. The devices meet essential regulatory benchmarks for lab instrumentation: conformity with IEC 61010-1 (safety), IEC 61326-1 (EMC), and RoHS Directive 2011/65/EU. While not FDA-cleared medical devices, their design supports GLP- and GMP-aligned workflows—particularly when integrated into validated assay protocols compliant with ISO/IEC 17025, CLSI EP05-A3, or USP <1058> Analytical Instrument Qualification guidelines.

Software & Data Management

The DB70-2A, IS70-2A, and MIX200-4 operate via intuitive front-panel controls with membrane keypad and LCD interface—no external software required for routine operation. All parameters (set temperature, speed, time) are stored in non-volatile memory and retained after power cycling. For traceability in regulated environments, optional RS-232 or USB-to-serial interfaces (available upon request) enable connection to LIMS or ELN systems, supporting timestamped parameter logging and basic remote start/stop commands. Audit trail functionality is implemented at the instrument firmware level, recording user-initiated changes with date/time stamps—aligning with FDA 21 CFR Part 11 requirements when paired with appropriate access control and electronic signature policies.

Applications

• Enzyme-linked immunosorbent assay (ELISA) plate washing and incubation steps
• Cell culture maintenance during transient transfection or drug screening assays
• Optimization of hybridization conditions in DNA/RNA microarray workflows
• Accelerated solubility and dissolution testing of biopharmaceutical formulations in microplate format
• Thermal profiling of protein stability (e.g., DSF-like assays using SYPRO Orange)
• Microbial growth curve analysis under controlled agitation and temperature

FAQ

Can these units maintain temperature uniformity across all wells of a 384-well plate?
Yes—validated chamber airflow and heater placement ensure ≤ ±0.3 °C uniformity across the full plate surface at steady state, as confirmed per ISO 17025-accredited internal calibration procedures.
Is CO₂ control available on any model in this series?
No—these are strictly temperature- and agitation-controlled incubators; CO₂ regulation requires dedicated CO₂ incubators or add-on gas modules not supported by this platform.
What is the maximum allowable load when operating at 1500 rpm?
At full speed (1500 rpm), the IS70-2A is rated for two standard 96-well plates (max. 200 g total mass); exceeding this may affect long-term motor longevity and thermal stability.
Are replacement parts such as plate carriers or silicone grips available separately?
Yes—XIU LAB supplies OEM-certified accessories including SBS-compatible carriers, high-temp silicone mats, and calibration verification kits (traceable to NIST standards).
Does the device support programmable ramp-and-hold temperature profiles?
No—these models offer single-setpoint temperature control only; multi-step thermal programming requires integration with external controllers or higher-tier platforms.