YUYANBIO Mouse ECG Measurement System

Overview

The YUYANBIO Mouse ECG Measurement System is a dedicated, high-fidelity electrophysiological recording platform engineered for non-invasive and minimally invasive cardiac and neuromuscular signal acquisition in small laboratory animals. Based on differential bio-potential amplification and precision analog-to-digital conversion, the system captures surface electrocardiograms (ECG), electromyograms (EMG), and electrooculograms (EOG) with low-noise performance and high temporal fidelity. It supports standardized lead configurations—including Lead I, Lead II, and derived leads (III, aVR, aVL, aVF)—enabling quantitative assessment of heart rate variability (HRV), P-QRS-T morphology, conduction intervals (PR, QRS, QT), and arrhythmia detection. Designed for integration into cardiovascular pharmacology, toxicology screening, and translational physiology workflows, the system complies with fundamental electrophysiological measurement principles outlined in ISO 14155 (clinical investigation of medical devices) and aligns with GLP-relevant data integrity requirements when configured with audit-trail-enabled software.

Key Features

• Modular architecture supporting scalable channel expansion: up to 6 ECG + 6 EMG, 8 EMG-only, or 12-lead ECG configurations per subject
• Simultaneous multi-animal recording capability—up to 128 total channels via synchronized amplifier daisy-chaining
• Integrated thermostatically controlled heating pad (32–38 °C range) to maintain physiological core temperature during prolonged recordings
• Color-coded, low-impedance Ag/AgCl electrodes and shielded lead wires optimized for murine thoracic anatomy and signal-to-noise ratio
• USB bus-powered design ensures portability and eliminates external power supply interference; compatible with Windows and macOS via USB 2.0/3.0
• Optional intracardiac 8-electrode catheter (platinum-tipped) for high-resolution local electrogram mapping and pacing-capable electrophysiology studies
• Built-in respiratory monitoring via impedance pneumography or auxiliary transducer input

Sample Compatibility & Compliance

The system is validated for use across multiple preclinical species including C57BL/6 and CD-1 mice, Sprague-Dawley and Wistar rats, New Zealand White rabbits, beagle dogs, and non-human primates. Neonatal mouse and zebrafish adaptations are available through specialized electrode arrays and miniature lead interfaces. All hardware components meet IEC 61000-4 electromagnetic compatibility standards and carry CE marking for research-use-only (RUO) applications in the EU and North America. When operated with LabScribe’s optional 21 CFR Part 11 module, the system supports electronic signatures, user access controls, and immutable audit trails required for regulated safety pharmacology studies under ICH S7B and FDA guidance.

Software & Data Management

LabScribe v4.x serves as the unified acquisition and analysis environment, providing real-time waveform visualization, automated beat detection, interval annotation, and customizable report generation. The ECG-specific analysis module computes time-domain HRV metrics (SDNN, RMSSD, pNN50), frequency-domain parameters (LF/HF ratio), and morphological descriptors (T-wave amplitude, ST-segment deviation). Raw data exports to ASCII, MATLAB (.mat), and HDF5 formats ensure interoperability with Python-based analysis pipelines (e.g., SciPy, Neo, Elephant libraries). Version-controlled software updates are delivered free of charge for the product’s supported lifecycle, with documentation aligned to ISO/IEC 17025 traceability requirements for instrument calibration records.

Applications

• Preclinical evaluation of cardiotoxic compounds (hERG liability, QT prolongation)
• Longitudinal monitoring of myocardial infarction or heart failure models
• Neuromuscular junction physiology in dystrophic or neurodegenerative mouse strains
• Autonomic nervous system modulation studies (vagal tone, sympathetic reactivity)
• Validation of optogenetic or chemogenetic cardiac pacing interventions
• High-throughput ECG phenotyping in genetically modified animal cohorts

FAQ

Is this system suitable for conscious, unrestrained recordings?
Yes—the portable USB-powered design, lightweight electrodes, and low-profile harness options support chronic telemetry-free recordings in restrained or semi-restrained paradigms. For fully ambulatory studies, contact technical support regarding compatible motion artifact suppression protocols.
Can I integrate third-party sensors (e.g., blood pressure, temperature) with this system?
Absolutely—the analog input channels accept ±10 V signals from calibrated transducers, and LabScribe supports synchronized multi-sensor acquisition with timestamp alignment at sub-millisecond resolution.
Does the system include validation documentation for GLP-compliant labs?
Standard delivery includes factory calibration certificates and electrical safety test reports. Optional IQ/OQ documentation packages and on-site installation qualification services are available upon request.
What is the typical signal latency between acquisition and display?
End-to-end latency is ≤12 ms at 10 kS/s sampling, verified using NIST-traceable pulse generators and oscilloscope cross-correlation.
Are replacement electrodes and consumables available separately?
Yes—sterile, pre-gelled Ag/AgCl electrodes (mouse-specific sizing), reusable platinum needle electrodes, and neonatal zebrafish suction cups are stocked and shipped globally.