Nichiryo MODEL8800 8-Channel Manual Continuous Dispenser

Overview

The Nichiryo MODEL8800 is an 8-channel manual continuous dispenser engineered for high-reproducibility liquid handling in standardized microplate workflows—particularly 96-well plate filling, serial dilution setup, and reagent pre-aliquoting. Unlike conventional multi-channel pipettes that rely on discrete piston strokes per dispense, the MODEL8800 employs a precision-machined, lever-actuated syringe drive system that enables uninterrupted, metered fluid delivery across all eight channels simultaneously. Its core mechanism utilizes calibrated glass or polypropylene syringes (Type A: 520 µL; Type B: 1300 µL) with fixed-volume displacement per stroke, ensuring consistent volumetric output without electronic control or motorized actuation. Designed and manufactured in Japan to stringent JIS-compliant tolerances, the device delivers traceable accuracy (±2.0%) and low intra-run variability (CV ≤1.2%) across its six factory-set dispensing volumes (10, 20, 25, 40, 50, and 100 µL), making it suitable for applications requiring GLP-aligned documentation and repeatable manual throughput.

Key Features

• True 8-channel parallel dispensing: All eight needles dispense synchronously from a single lever actuation—eliminating inter-channel timing drift and reducing operator-induced variability.
• Six user-selectable fixed-volume settings (10, 20, 25, 40, 50, 100 µL) with mechanical stop-limit adjustment—no digital interface required, minimizing calibration dependencies and software validation burden.
• Modular, autoclavable architecture: Syringes, needle holders, and main body components are rated for full-cycle steam sterilization (121°C, 20 min), supporting ISO 13485-compliant cleanroom reuse and cross-contamination mitigation in QC labs.
• Adjustable dispensing speed via integrated flow-resistance regulator—enabling controlled delivery into low-retention or volatile solvent systems without splashing or bubble formation.
• Compact ergonomic form factor (285 × 82 × 23 mm with syringes installed) optimized for benchtop integration alongside plate stackers, incubators, and automated readers.

Sample Compatibility & Compliance

The MODEL8800 accommodates aqueous buffers, cell culture media, enzyme solutions, organic solvents (e.g., ethanol, DMSO), and viscous glycerol-based reagents up to ~15 cP, provided syringe wetted materials (borosilicate glass or chemically resistant PP) remain compatible. Needle options include standard stainless steel (26G, 0.45 mm ID) and low-binding PTFE-coated variants. The device meets JIS Z 3800:2021 requirements for manual liquid dispensers and supports compliance with ISO/IEC 17025 clause 6.4.3 (equipment suitability verification). While not electronically auditable, its mechanical repeatability allows full traceability when used within documented SOPs aligned with FDA 21 CFR Part 11 Annex 11 principles for manual systems—particularly where audit trails are maintained via lab notebook entries linked to batch records.

Software & Data Management

The MODEL8800 operates entirely without embedded firmware, software, or connectivity interfaces—reducing cybersecurity exposure and eliminating validation overhead associated with electronic data capture. Volume selection, dispensing count, and sterilization logs are recorded manually in laboratory notebooks or LIMS-integrated paper-based workflows. For laboratories requiring digital linkage, optional barcode-labeled syringe kits and volume-setting templates enable structured entry into validated ELN platforms (e.g., LabArchives, Benchling) using predefined metadata fields (e.g., “Dispenser_ID”, “Syringe_Type”, “Volume_Set”, “Sterilization_Date”). No proprietary drivers or cloud services are involved.

Applications

• High-throughput 96-well plate seeding for cell-based assays (e.g., cytotoxicity, proliferation, reporter gene expression).
• Preparation of serial dilution series in ELISA, qPCR master mix assembly, and antibody titration workflows.
• Consistent reagent loading into microfluidic cartridges and lateral flow test strip reservoirs.
• QC release testing of raw materials where manual dispensing must meet ISO 8655-5 accuracy criteria for fixed-volume dispensers.
• Teaching laboratories emphasizing fundamental liquid handling principles, reproducibility assessment, and error source analysis.

FAQ

Is the MODEL8800 compatible with 384-well plates?
No—it is mechanically optimized for 96-well spacing (standard 9 mm pitch); use with 384-well formats requires adapter plates or alternative single-channel dispensing.
Can I calibrate the device in-house?
Yes—gravimetric calibration per ISO 8655-5 is supported using Class A analytical balances and certified reference water; calibration certificates may be generated per internal SOP without external certification.
What maintenance is required between sterilization cycles?
After autoclaving, inspect O-rings for deformation, verify lever spring tension, and confirm syringe plunger seal integrity using a 10 µL air-displacement test before resuming critical use.
Does Nichiryo provide replacement syringes and needles?
Yes—genuine OEM syringes (A/B types), stainless steel needles (26G, 30G), and PTFE-coated variants are available under part numbers SYR-A-520, SYR-B-1300, and NDL-26G-PTFE, with full traceability documentation.
Is the device compliant with EU RoHS and REACH directives?
Yes—material declarations and SVHC screening reports are supplied with each unit shipment, confirming conformity with Directive 2011/65/EU and Regulation (EC) No. 1907/2006.