YUYANBIO YAN-105A Small Animal Three-Part Differential Hematology Analyzer
| Brand | YUYANBIO |
|---|---|
| Origin | Shanghai, China |
| Manufacturer Type | Direct Manufacturer |
| Country of Origin | China |
| Model | YAN-105A |
| Price Range | USD 4,200 – 12,600 (FOB) |
| Throughput | 100 samples/hour |
| Sample Volume | 17 µL (whole blood mode) |
| Sample Type | Whole blood (native or pre-diluted) |
| Loading Mode | Fully automated aspiration and processing |
| Detection Principle | Coulter impedance + non-cyanide colorimetric hemoglobin assay |
| Output | 3-parameter histogram (WBC, RBC, PLT), integrated thermal printer, 50,000-sample onboard storage |
Overview
The YUYANBIO YAN-105A Small Animal Three-Part Differential Hematology Analyzer is a dedicated benchtop instrument engineered for precise, reproducible hematologic profiling of preclinical research models. It employs dual-modality detection: Coulter impedance principle for volumetric-based cell counting and sizing of white blood cells (WBC), red blood cells (RBC), and platelets (PLT); and a non-cyanide colorimetric method for accurate hemoglobin (HGB) quantification—eliminating hazardous reagent handling while maintaining traceable photometric performance per CLSI EP6-A guidelines. Designed specifically for laboratory animal science, the system delivers standardized three-part WBC differential (lymphocytes, monocytes, granulocytes) with species-specific calibration profiles validated across 17 common research species—including Mus musculus, Rattus norvegicus, Cavia porcellus, Canis lupus familiaris, and Macaca fascicularis. Its architecture supports GLP-compliant workflows through audit-trail-capable data logging and user-accessible calibration verification reports.
Key Features
- Three-parameter histogram generation (WBC, RBC, PLT) with real-time visualization on a 10.4-inch capacitive touchscreen interface—enabling immediate morphological assessment of cell population distribution.
- Minimal sample requirement: only 17 µL of native whole blood enables full CBC+diff analysis, reducing animal stress and conserving precious longitudinal samples.
- Fully automated fluidic path with integrated probe cleaning, diluent aspiration, and waste management—eliminating manual rinsing steps between samples.
- Onboard thermal printer outputs complete CBC reports including all 22 parameters, histograms, and species-annotated reference ranges; optional USB or Ethernet connectivity supports external PDF report export with embedded graphics.
- Embedded database stores up to 50,000 test records with full metadata: animal ID, species, date/time stamp, operator ID, histogram snapshots, and QC flag status.
- Self-diagnostic routines include daily system checks, clog detection, voltage stability monitoring, and automatic standby/awake cycling to extend component lifetime and ensure consistent baseline performance.
Sample Compatibility & Compliance
The YAN-105A is validated for use with anticoagulated (EDTA-K2/K3) whole blood from 17 regulated laboratory species. Each species profile includes analytically verified linearity, precision (CV ≤ 3.5% for WBC, ≤ 2.0% for RBC, ≤ 4.8% for PLT per CLSI H20-A2), and carryover (< 0.5% for WBC). Calibration verification reports conform to ISO 15197:2013 principles for veterinary in vitro diagnostics and support institutional IACUC documentation requirements. The analyzer meets electromagnetic compatibility (EMC) standards per IEC 61326-1 and electrical safety per IEC 61010-1. Reagents are CE-marked as Class B IVD products and registered under China NMPA Class II medical device regulations (Registration No.: 2022222XXXXX).
Software & Data Management
Firmware v3.2.1 provides role-based access control (administrator, technician, guest), configurable report templates, and time-stamped audit logs compliant with 21 CFR Part 11 Annex 11 expectations for electronic records. Data export supports CSV, PDF, and HL7 v2.5 formats. Optional YUYANBIO LabLink™ middleware enables bidirectional integration with LIMS platforms via TCP/IP or serial RS-232 protocols. All histogram and scattergram raw data are retained in proprietary .YDB binary format—decryptable only by authorized software versions to preserve analytical integrity.
Applications
- Longitudinal hematologic monitoring in oncology, immunology, toxicology, and metabolic disease models.
- Pre- and post-treatment CBC assessment for dose-response studies and PK/PD correlation.
- Validation of genetically engineered animal models exhibiting hematopoietic phenotypes.
- Supporting regulatory submissions requiring species-specific hematologic reference intervals (e.g., FDA Guidance for Industry: “Toxicokinetics and Toxicodynamics in Nonclinical Safety Studies”).
- Core facility deployment where throughput, minimal hands-on time, and cross-species flexibility are operationally critical.
FAQ
What species-specific validation documentation is provided with the instrument?
Each unit ships with a Certificate of Species Performance Verification, including precision, linearity, and comparison-to-reference-method data for all 17 supported species.
Does the analyzer support custom reference range definition for institutional colonies?
Yes—users may import and activate colony-specific reference intervals via encrypted configuration files, with version-controlled revision history.
Is routine maintenance required beyond daily startup checks?
No scheduled consumable replacement is needed within the first 12 months; the system alerts for probe cleaning cycle initiation based on actual usage metrics.
Can the YAN-105A interface with third-party animal ID systems (e.g., RFID scanners)?
Via optional TTL-level GPIO expansion module, enabling hardware-triggered sample start and auto-population of animal ID fields.
How is hemoglobin measurement accuracy ensured without cyanide-based reagents?
The non-cyanide chromogen exhibits molar absorptivity matching that of cyanmethemoglobin at 540 nm, with calibration traceable to NIST SRM 909c lyophilized blood reference material.
