LabTech PrepElite-SV Automated Sample Preparation Platform

Overview

The LabTech PrepElite-SV Automated Sample Preparation Platform is an integrated, fully programmable system engineered for high-throughput, reproducible sample cleanup and concentration prior to chromatographic analysis. It implements a modular architecture combining column-based solid-phase extraction (SPE) with dual-vessel online concentration—enabling sequential or parallel operation of SPE and evaporation steps without manual intervention. The platform operates on the principle of vacuum-assisted, flow-controlled solvent delivery and pressure-regulated elution, ensuring consistent bed conditioning, loading, washing, and elution across all channels. Designed specifically for complex matrices—including fatty tissues, edible oils, pesticide-spiked agricultural commodities, and environmental sediments—the PrepElite-SV delivers robust recovery (>85% for polar and non-polar analytes per ASTM D7066-22 validation protocols) while minimizing matrix interference and column fouling in downstream GC or LC systems.

Key Features

• Fully automated, walk-away operation with 24/7 unattended runtime supported by sealed enclosure and real-time hardware diagnostics
• Dual-concentration module featuring two independent borosilicate glass concentrator cups, enabling simultaneous evaporation of two fractions or staggered processing to reduce total cycle time by up to 40% versus single-vessel systems
• Multi-channel SPE module (PrepElite-GVS architecture) with precise, low-pulsation peristaltic pumping and vacuum manifold control for uniform flow distribution across up to 24 columns
• Eight-solvent selection system with chemically resistant fluid paths and automatic valve sequencing—supports gradient elution, multi-step wash protocols, and method-specific solvent switching
• Modular design allows standalone use of either SPE or concentration units, or seamless integration into end-to-end workflows including pre-concentration → SPE → post-elution concentration → direct transfer to autosampler vials
• Glass-wetted fluid path (including sample loops, eluate lines, and concentrator vessels) ensures compatibility with aggressive solvents (e.g., DCM, acetone, ethyl acetate) and eliminates leaching or adsorption artifacts
• Configurable rack support accommodating standard 12×10 vial trays (12 mL, 16 mL, 20 mL), custom inserts, and optional barcode scanning for full sample traceability

Sample Compatibility & Compliance

The PrepElite-SV accommodates liquid, semi-solid, and homogenized solid samples following appropriate dilution or solvent extraction. Validated applications include QuEChERS extracts, Bligh-Dyer lipid fractions, EPA Method 508/525 aqueous extracts, and ISO 14501-2 pesticide residue preparations. All wetted materials comply with USP , FDA 21 CFR Part 11 (when paired with LabTech’s AuditTrail-enabled software), and GLP/GMP documentation requirements. System performance meets ISO/IEC 17025 criteria for precision (RSD ≤ 5% for triplicate fortified recoveries) and linearity (r² ≥ 0.999 over 10–1000 ng/mL ranges). CE marking and RoHS compliance are certified for EU deployment.

Software & Data Management

Controlled via LabTech’s PrepSuite™ v4.2 software, the platform supports intuitive method building with drag-and-drop workflow editor, real-time monitoring of vacuum levels, flow rates, and temperature, plus automated calibration logging. Audit trails record all user actions, parameter changes, and instrument events with timestamped, non-erasable entries compliant with 21 CFR Part 11 Subpart B. Data export options include CSV, PDF reports, and direct LIMS integration via ASTM E1384-compliant XML schema. Language interface toggles between English and Simplified Chinese without restart.

Applications

• Multi-residue pesticide analysis in fruits, vegetables, and cereals (aligned with EU SANTE/11312/2021 guidelines)
• Lipid-rich food matrices: mycotoxin cleanup in peanut butter, aflatoxin B1 in corn oil, PCBs in fish tissue
• Environmental water and soil extracts: PAHs, organochlorines, and pharmaceutical residues per EPA SW-846 Methods 3535A and 3545B
• Biomonitoring workflows: steroid hormones in serum, vitamin D metabolites in plasma, and neurotransmitter derivatives in brain homogenates
• Method development labs requiring rapid optimization of SPE sorbent types, solvent gradients, and evaporation profiles

FAQ

Can the PrepElite-SV be integrated with third-party LC/GC autosamplers?
Yes—via standardized 12 mm or 15 mm vial output trays and optional robotic arm interface kits compatible with major OEM platforms (e.g., Agilent, Thermo Fisher, Shimadzu).
Is method validation data available for regulatory submissions?
LabTech provides IQ/OQ/PQ documentation packages and application notes aligned with AOAC 2012.01, ISO 17025, and EU Commission Regulation (EU) No 2021/2000.
What maintenance intervals are recommended for long-term reliability?
Vacuum pump oil change every 6 months; glassware inspection and O-ring replacement annually; full system performance verification quarterly using certified reference standards.
Does the system support method transfer from manual SPE protocols?
Yes—PrepSuite™ includes a protocol conversion wizard that maps manual steps (e.g., “condition with 5 mL methanol, then 5 mL water”) to corresponding automated parameters with flow rate, dwell time, and vacuum setpoint translation.