KEZHE VNH-1500 Vacuum Parallel Concentrator

Overview

The KEZHE VNH-1500 Vacuum Parallel Concentrator is an engineered solution for high-throughput, reproducible solvent removal from multiple liquid samples under controlled vacuum, thermal, and mechanical conditions. It operates on the principle of simultaneous vacuum-assisted evaporation combined with regulated conductive heating and orbital shaking—enabling rapid concentration while minimizing thermal stress and cross-contamination. Unlike single-tube concentrators, the VNH-1500 supports parallel processing of up to 36 samples in a single run, making it particularly suited for laboratories engaged in environmental analysis, pharmaceutical development, clinical research, and natural product isolation where batch consistency, trace analyte recovery, and GLP-compliant documentation are critical.

Key Features

• Independent vacuum channel per sample tube—eliminates vapor-phase carryover and ensures true sample isolation;
• Triple-sided transparent water bath chamber with unobstructed bottom-view access—enables real-time visual monitoring of meniscus recession and endpoint detection;
• Integrated programmable temperature gradient control (up to 9 steps) and vacuum ramping profiles—supports method optimization for thermolabile compounds;
• Orbital shaking (0–300 rpm) enhances surface area exposure and mass transfer kinetics without splashing or foaming;
• Condensate recovery system captures evaporated solvents—complies with ISO 14001 laboratory environmental management requirements and eliminates indoor VOC emissions;
• Heated lid design prevents condensation buildup on the cover surface—maintains consistent vapor pressure gradients across all tubes;
• Self-regulating water level management via automatic fill/drain function—reduces manual intervention and improves operational continuity;
• Modular architecture allows seamless integration with upstream extraction platforms including ASE (Accelerated Solvent Extraction) and SPE (Solid-Phase Extraction) systems—enabling direct transfer-free workflow consolidation;
• Digital vacuum sensor feedback loop ensures precise, repeatable pressure control across all channels—critical for inter-batch comparability in regulated environments.

Sample Compatibility & Compliance

The VNH-1500 accommodates standard microcentrifuge tubes (0.5 mL and 1 mL tail volumes), culture tubes, and custom-format vessels via interchangeable sample racks. Its design adheres to core principles of analytical method robustness defined in ICH Q2(R2) and supports compliance with FDA 21 CFR Part 11 when paired with audit-trail-enabled software extensions (available separately). The instrument’s closed-loop solvent recovery meets EPA Method 502.2 and 8081B prerequisites for halogenated organics handling. All wetted components are chemically resistant to common organic solvents (e.g., acetonitrile, methanol, dichloromethane, ethyl acetate), and the stainless-steel chamber complies with ISO 8573-1:2010 Class 3 air purity standards for non-oiled vacuum systems.

Software & Data Management

Control is executed through an intuitive touchscreen interface supporting multilingual operation (English, Chinese, Spanish). Users may define and store up to 20 independent protocols—including temperature ramps, vacuum setpoints, shaking speed profiles, and duration sequences—with timestamped execution logs. Optional PC-based software (KEZHE LabLink™) provides remote monitoring, CSV export of real-time sensor data (temperature, pressure, time), and electronic signature functionality compatible with GxP-aligned validation packages. Audit trail records include operator ID, parameter changes, start/stop events, and error flags—meeting ALCOA+ data integrity criteria for QC/QA labs operating under ISO/IEC 17025 or USP .

Applications

• Routine concentration of LC-MS/MS extracts prior to reconstitution and injection;
• High-volume sample prep for pesticide residue screening in food safety testing (AOAC 2007.01, EN 15662);
• Post-SPE cleanup of biological matrices (plasma, urine, tissue homogenates) in pharmacokinetic studies;
• Concentration of environmental water extracts for PAHs, PCBs, and organochlorine pesticides (EPA 1613B, 8270D);
• Pre-concentration of natural product fractions during phytochemical isolation workflows;
• Parallel desalting and buffer exchange in proteomics sample preparation (compatible with TFA, ammonium acetate, and volatile buffers).

FAQ

What is the maximum number of samples the VNH-1500 can process simultaneously?
The system supports two configurations: 16-position (300 mL total capacity) or 36-position (80 mL total capacity), selected at time of order based on tube format and application requirements.
Does the instrument support gradient vacuum control?
Yes—users may program up to nine discrete vacuum setpoints over time, enabling staged pressure reduction optimized for multi-solvent systems or sensitive analytes.
Is the vacuum pump maintenance-free?
The integrated diaphragm vacuum pump requires no oil changes and features variable-speed control; routine filter replacement every 6–12 months is recommended depending on solvent load.
Can the VNH-1500 be validated for use in regulated laboratories?
Yes—the hardware architecture supports IQ/OQ/PQ documentation, and optional software modules provide 21 CFR Part 11 compliance features including electronic signatures, audit trails, and role-based access control.
What safety certifications does the unit carry?
The VNH-1500 conforms to IEC 61010-1:2010 for electrical safety in laboratory equipment and carries CE marking under the EU Machinery Directive 2006/42/EC and EMC Directive 2014/30/EU.