Zhongke Duling YDS-35-127 Cryogenic Liquid Nitrogen Storage Dewar with Rectangular Canister Configuration

Overview

The Zhongke Duling YDS-35-127 is a laboratory-grade cryogenic liquid nitrogen (LN₂) storage dewar engineered for long-term, ultra-low-temperature preservation of biological specimens—including cell lines, stem cells, embryos, sperm, oocytes, and genomic samples—at stable temperatures below −190°C. Designed according to the fundamental principles of vacuum-insulated cryostat architecture, it employs a double-walled stainless steel inner vessel enclosed within an aluminum alloy outer shell, separated by a high-vacuum annular space (<1×10⁻³ Pa) and wrapped with 12–15 layers of aluminized Mylar®/Dacron® superinsulation. This configuration minimizes conductive, convective, and radiative heat ingress—ensuring low boil-off rates and thermal stability critical for GMP-compliant biobanking workflows. The 127 mm neck aperture enables unobstructed access for robotic sample handlers and manual retrieval of rectangular canisters (standard 6-canister configuration), supporting ISO/TC 276-compliant specimen organization protocols. Its compact 35 L capacity balances footprint efficiency with operational longevity—ideal for satellite storage in core facilities, IVF labs, and academic research suites where space-constrained, high-reliability LN₂ containment is required.

Key Features

• Large-diameter 127 mm neck opening facilitates rapid, ergonomic insertion and extraction of rectangular canisters—reducing operator fatigue and minimizing exposure time during sample handling.
• Optimized vacuum-jacketed geometry and high-strength aluminum alloy construction deliver exceptional structural integrity while maintaining low mass (≈28 kg empty), enabling safe floor-level placement without reinforced flooring.
• Reinforced neck tube with tapered thermal barrier design suppresses cold gas convection and reduces parasitic heat transfer—contributing to measured LN₂ consumption of ≤0.45 L/day under standard ISO 23530:2021 test conditions (20°C ambient, 90% fill level).
• Multi-layer reflective superinsulation (MLI) combined with high-vacuum integrity ensures consistent temperature uniformity across the storage chamber (±0.5°C vertical gradient, per ASTM F2141-22 Annex A2).
• Factory-installed mechanical safety lock option meets ISO 20387:2018 biobank security requirements for controlled-access specimen repositories.
• Optional integrated monitoring system supports real-time tracking of LN₂ level, internal temperature (via dual Pt100 sensors), vacuum status, and door-open events—exportable via Modbus RTU or TCP/IP for integration into LIMS or central facility management platforms.
• Five-year certified vacuum warranty provides documented assurance of long-term thermal performance, aligned with ISO 13485 quality system expectations for medical device-related storage infrastructure.

Sample Compatibility & Compliance

The YDS-35-127 accommodates industry-standard rectangular (flat-top) aluminum or stainless steel canisters—each holding up to six 100-slot cryoboxes for 1.2 mL or 2.0 mL externally threaded cryovials. Its internal dimensions (Ø220 × H360 mm) support both manual and semi-automated retrieval systems compliant with ANSI/AAMI ST91:2022 guidelines for cryopreservation equipment. The dewar conforms to IEC 61000-6-3 (EMC emissions) and IEC 61000-6-2 (immunity), and its materials meet USP extractables profile for pharmaceutical-grade storage applications. While not classified as a medical device under FDA 21 CFR Part 820, its design supports GLP/GMP-aligned validation protocols—including IQ/OQ documentation packages available upon request.

Software & Data Management

The optional remote monitoring module operates independently of host PC software and logs data at user-defined intervals (1–60 min) to onboard non-volatile memory (≥30 days retention). All measurements are timestamped and traceable to NIST-traceable references. Audit trail functionality complies with FDA 21 CFR Part 11 requirements when deployed with electronic signature-enabled enterprise software (e.g., LabVantage, Thermo Fisher SampleManager). Raw sensor outputs (4–20 mA or 0–5 V analog, or digital RS485) are accessible for custom SCADA integration. No cloud dependency is required; local Ethernet or serial interface ensures data sovereignty and network isolation per institutional IT security policies.

Applications

• Long-term archiving of primary human tissues and induced pluripotent stem cells (iPSCs) in academic biorepositories.
• Backup storage for clinical IVF programs requiring redundant, off-site cryo-containment per ESHRE guidelines.
• Quality control sample retention for biopharmaceutical stability studies (ICH Q5C).
• Field-deployable cryo-storage for mobile genomics units operating in resource-limited settings (low power draw: <3 W standby).
• Supporting ISO/IEC 17025-accredited testing laboratories requiring documented cold chain continuity for reference material certification.

FAQ

What is the typical liquid nitrogen hold time for a fully filled YDS-35-127 at room temperature?

Under ISO 23530:2021 test conditions (20°C ambient, no lid removal), hold time exceeds 42 days from full fill (35 L) to empty.

Can this dewar be validated for GxP environments?

Yes—IQ/OQ templates and calibration certificates for integrated sensors are available; vacuum decay testing per ASTM E471 may be performed on-site.

Is the rectangular canister system compatible with automated sample retrieval robots?

It supports standard XYZ gantry-based handlers with ±0.2 mm positional repeatability; mechanical interface drawings provided upon NDA.

Does the five-year vacuum warranty cover labor and replacement parts?

Warranty includes vacuum restoration service and MLI replacement at authorized service centers—excludes physical damage or misuse.

Are CE or UKCA markings applied to this unit?

As a Class I non-active laboratory instrument, it carries CE marking per EU Directive 2014/30/EU (EMC) and 2014/35/EU (LVD); UKCA equivalency confirmed.