HPSE Ultra Series High-Efficiency Accelerated Solvent Extractor by LabTech

Overview

The HPSE Ultra Series High-Efficiency Accelerated Solvent Extractor is an engineered solution for automated, high-throughput extraction of organic analytes from solid and semi-solid matrices. It operates on the principle of accelerated solvent extraction (ASE®), applying elevated temperature (up to 200 °C) and pressure (up to 20 MPa) to enhance solvation power and mass transfer kinetics while maintaining sample integrity. Unlike conventional Soxhlet or ultrasonic-assisted extraction, the HPSE Ultra achieves complete extractions in minutes—not hours—by optimizing solvent penetration and analyte desorption under controlled thermodynamic conditions. Its modular architecture supports method development, routine QC, and regulatory-compliant workflows across environmental, food safety, pharmaceutical, and traditional Chinese medicine (TCM) laboratories.

Key Features

• Multi-channel parallel processing: Configurable 2-, 4-, or 6-channel operation enables simultaneous extraction of up to six samples, improving laboratory throughput without compromising reproducibility.
• Dynamic pressure regulation: Each channel integrates an independent high-flow pump (100 mL/min nominal capacity) with real-time pressure feedback control, automatically adjusting output to match cartridge volume (1–100 mL) and method-defined pressure setpoints (5–20 MPa).
• Auto-sealing cartridge technology: Utilizes self-aligning, force-actuated sealing mechanism—no manual torque application required. Sealing force is applied pneumatically prior to pressurization, eliminating operator-dependent variability and preventing leakage during extended runs.
• Integrated containment design: Fully enclosed solvent path and sealed extraction chamber minimize volatile organic compound (VOC) emissions. Built-in ventilation port complies with ISO 14644-1 Class 8 cleanroom-compatible exhaust interface standards and allows direct ducting to central lab fume hoods or scrubber systems.
• Thermal stability & precision: Heated extraction chamber maintains ±1 °C temperature uniformity across all positions; integrated thermal sensors provide continuous monitoring and closed-loop PID control.

Sample Compatibility & Compliance

The HPSE Ultra accommodates a broad range of sample types—including soils, sediments, air filters, plant tissues, animal feed, herbal powders, and processed foods—using standard ASE-compatible extraction cells (1–100 mL). All wetted components are constructed from chemically resistant materials (e.g., stainless steel 316, PEEK, and fluoropolymer seals) compatible with common organic solvents (hexane, acetone, dichloromethane, methanol, acetonitrile, and water-miscible mixtures). The system meets key regulatory prerequisites for method validation per EPA Methods 3545A and 3546, ASTM D7699, and ISO 14507-2. Its operational log, parameter audit trail, and user-access-level controls support GLP/GMP-aligned documentation requirements and are compatible with FDA 21 CFR Part 11–compliant data management platforms when interfaced via Ethernet.

Software & Data Management

Controlled via LabTech’s proprietary HPSE Control Suite (v4.x), the instrument provides intuitive method building, real-time run monitoring, and event-driven alarm logging. Each extraction cycle generates a timestamped metadata record—including temperature ramp profiles, pressure curves, solvent delivery volumes, and seal integrity verification status. Raw data exports in CSV and XML formats facilitate integration with LIMS (e.g., Thermo Fisher SampleManager, LabVantage) and statistical analysis tools (e.g., JMP, Minitab). Optional software modules include method validation templates aligned with ICH Q2(R2), electronic signature support, and configurable electronic audit trails compliant with ALCOA+ principles.

Applications

• Environmental analysis: PAHs, PCBs, organochlorine pesticides, and petroleum hydrocarbons in soil, sludge, and airborne particulates (per EPA SW-846).
• Food safety testing: Mycotoxins (aflatoxins, ochratoxin A), pesticide residues, fat-soluble vitamins, and antioxidant compounds in cereals, dairy, meat, and botanicals.
• Phytochemical research: Standardized extraction of flavonoids, alkaloids, saponins, and essential oils from TCM herbs under reproducible thermal-solvent conditions.
• Materials science: Leachables and extractables profiling from packaging polymers, medical device components, and industrial catalysts.

FAQ

What sample matrices are validated for use with the HPSE Ultra?
Soil, sediment, air filters, dried plant material, powdered foodstuffs, and homogenized biological tissues have been verified across multiple interlaboratory studies.
Can the system be upgraded from 2-channel to 6-channel post-purchase?
Yes—hardware expansion kits and firmware updates are available for field installation without returning the base unit.
Is method transfer supported between different HPSE Ultra configurations?
Yes—method files retain full parameter fidelity across channel counts and cell sizes; only flow rate and heating time require minor recalibration for scale-up.
Does the system support gradient solvent programming?
No—solvent composition must be pre-mixed externally; however, sequential solvent delivery (e.g., rinse + extract) is programmable within a single run.
How is leak detection implemented during operation?
Pressure decay monitoring occurs during hold phases; a >5% pressure drop over 30 seconds triggers automatic abort and fault logging.