KRSYQ KRS-Y96 96-Channel Air-Displacement Liquid Handling Workstation

Overview

The KRSYQ KRS-Y96 is a benchtop 96-channel air-displacement liquid handling workstation engineered for precision, repeatability, and workflow integration in regulated and research-intensive laboratory environments. Based on positive air displacement technology—where a disposable tip seals against an internal piston to generate controlled vacuum and pressure—the system delivers high volumetric accuracy across its dual-range configuration (1–30 µL and 20–200 µL). Unlike fixed-volume or gravitational dispensing systems, air-displacement architecture enables programmable aspiration/dispense speeds, adjustable tip immersion depth, and real-time control over liquid surface contact—critical for viscous, volatile, or foaming samples. Designed for SBS-compliant microplates (including 96-, 384-, and custom-format plates), the KRS-Y96 supports end-to-end automation of plate filling, serial dilution, reagent addition, and sample transfer without manual intervention. Its compact footprint (58.0 × 27.7 × 57.0 cm) allows seamless integration into biosafety cabinets (BSCs), laminar flow hoods, and GLP-compliant lab benches.

Key Features

• Programmable multi-speed pipetting: Independent control over aspiration, dispense, and blow-out velocities ensures optimal handling of diverse liquid classes—including serum, glycerol solutions, detergents, and ethanol-based buffers.
• Dual-range capability: Interchangeable pipetting modules support two calibrated volume ranges—1–30 µL (CV ≤ 3.0%) and 20–200 µL (CV ≤ 1.5%)—validated per ISO 8655-6 and ASTM E2758 standards.
• Tip positioning accuracy: Z-axis motorized control enables precise, repeatable tip immersion depth adjustment (±0.1 mm resolution), minimizing carryover and surface tension artifacts during low-volume transfers.
• Full 96-channel synchronization: Simultaneous actuation with channel-to-channel volume deviation < ±1.2%, eliminating positional bias inherent in sequential 8-channel systems.
• Touchscreen HMI interface: 10.1-inch capacitive display with intuitive icon-driven workflow builder; supports protocol import/export via USB or network share; no external PC required for routine operation.
• Modular deck design: Four standardized deck positions accommodate SBS-format plates, tube racks, reservoirs, and optional accessories—including integrated Peltier-based temperature control modules (4–40 °C) for thermosensitive assays.

Sample Compatibility & Compliance

The KRS-Y96 accommodates standard ANSI/SBS-compliant microplates (96-, 384-, and 1536-well), PCR plates, deep-well blocks, and conical tube racks. Tip compatibility includes universal-fit filtered and non-filtered sterile tips (10–200 µL range). All liquid-contact surfaces are chemically resistant to common laboratory solvents (e.g., 70% ethanol, 0.5% SDS, 1 M NaOH) and autoclavable at 121 °C for up to 20 cycles. The system meets IEC 61000-6-2/6-3 (EMC immunity/emissions) and UL 61010-1 safety requirements. While not pre-certified for FDA 21 CFR Part 11, audit trails, electronic signatures, and user-access controls can be implemented via optional software add-ons compliant with GLP/GMP documentation frameworks.

Software & Data Management

Embedded firmware supports protocol creation via drag-and-drop step sequencing, including conditional logic (e.g., “if plate type = 384-well, then reduce dispense speed by 30%”). Raw execution logs—including timestamped tip usage, error codes, and volume verification flags—are stored locally and exportable as CSV or XML. Optional KRS-Link™ Software (v3.2+) adds remote monitoring, LIMS integration (via HL7 or REST API), and full 21 CFR Part 11 compliance with role-based permissions, electronic signatures, and immutable audit trails. Data integrity safeguards include automatic checksum validation upon file transfer and write-protected archive mode.

Applications

• Diagnostic assay setup: ELISA plate coating, antigen/antibody dilution series, and QC sample distribution in clinical microbiology and immunology labs.
• Drug discovery pipelines: High-throughput compound plating for ADME-Tox screening, CYP450 inhibition assays, and dose-response matrix generation.
• Molecular biology workflows: qPCR master mix dispensing, NGS library normalization, CRISPR guide RNA complex assembly, and cDNA synthesis setup.
• Biobanking operations: Aliquoting of plasma, serum, and PBMC suspensions into cryovials or storage plates with traceable lot-level metadata tagging.
• Regulatory testing: Sample preparation for pharmacopeial methods (USP <1058>, EP 2.6.27) in food safety, environmental testing, and pharmaceutical QC laboratories.

FAQ

Does the KRS-Y96 support variable tip spacing for non-standard plate formats?

Yes—via custom deck layout configuration and tip offset calibration, the system accommodates non-SBS plates (e.g., 48-well strips, custom molded blocks) with positional tolerance ≤ ±0.05 mm.
Can it perform reverse pipetting for viscous liquids?

Yes—reverse pipetting mode is programmable per step, with independent control over pre-wet volume, aspirate volume, and dispense volume to minimize residual adherence.
Is maintenance documentation available in English?

Yes—full technical manuals, calibration procedures, and preventive maintenance schedules are provided in English and updated quarterly via KRSYQ’s secure customer portal.
What is the recommended recalibration interval?

Annual volumetric verification is advised per ISO/IEC 17025 guidelines; however, daily performance checks using gravimetric verification protocols are supported out-of-the-box.
Are third-party tips validated for use with this platform?

KRSYQ maintains an open-tip compatibility list; tips from major suppliers (e.g., Eppendorf, Rainin, Gilson) have been verified for dimensional fit and sealing integrity under operational conditions.