Atmos ATMOS Pipette Accuracy Tester

Overview

The Atmos ATMOS Pipette Accuracy Tester is a gravimetric calibration system engineered for precision verification of manual, electronic, and multi-channel pipettes in compliance with international standards including ISO 8655-6 and ASTM E2791. It operates on the fundamental principle of high-resolution mass measurement: liquid dispensed by the pipette is deposited into a calibrated weighing pan connected to a temperature-compensated analytical balance module (0.01 mg resolution), and the measured mass is converted to volume using real-time environmental parameters—temperature, air pressure, and humidity—via integrated sensors. This ensures traceable, uncertainty-quantified results aligned with metrological best practices. Designed for routine QC/QA labs, reference laboratories, and ISO/IEC 17025-accredited facilities, the ATMOS delivers repeatable, operator-independent assessments of accuracy (bias), precision (CV%), linearity across volume ranges, tip compatibility, and carryover behavior—critical for method validation, equipment qualification (IQ/OQ/PQ), and regulatory audits.

Key Features

• Gravimetric calibration architecture with integrated environmental compensation (temperature, pressure, humidity) for volume calculation per ISO 8655-6 Annex B.
• Modular test head design supporting single-channel, 8-channel, and 12-channel pipettes (0.1 µL to 10 mL range) without mechanical reconfiguration.
• 7-inch capacitive touchscreen interface with intuitive workflow navigation, multilingual OS (English, German, French, Spanish), and context-sensitive help overlays.
• Real-time statistical engine calculating accuracy (% error vs. nominal), repeatability (CV%), linearity (R²), and tip-dependent deviation per ISO 8655-2.
• Onboard audit trail with user authentication (PIN or RFID), timestamped event logging, and immutable record storage meeting FDA 21 CFR Part 11 requirements.
• Low-power thermal management system with active airflow control and overheat shutdown—certified for continuous operation up to 8 hours at 25 °C ambient.
• Tool-free access to internal calibration ports and weighing chamber; stainless-steel weighing pan with chemical-resistant PTFE coating.

Sample Compatibility & Compliance

The ATMOS accommodates all major pipette brands—including Eppendorf, Gilson, Rainin, Thermo Fisher, Brandtech, and Socorex—across fixed-volume and adjustable-volume configurations. It supports both forward and reverse pipetting techniques and validates performance under standard (ISO 8655-2) and low-retention tip conditions. All calibration procedures adhere strictly to ISO 8655-6:2022 for gravimetric testing, and data outputs include expanded uncertainty budgets calculated per GUM (JCGM 100:2008). The system is pre-configured for GLP and GMP environments, with full support for electronic signatures, role-based permissions, and exportable audit logs compatible with LIMS integration via HL7 or RESTful API.

Software & Data Management

Firmware v3.2 includes embedded PipetteCal™ software with automated report generation compliant with ISO/IEC 17025 clause 7.8. Test reports include instrument ID, operator ID, environmental metadata, raw mass readings, volume calculations, statistical summaries, pass/fail status per user-defined acceptance criteria (e.g., ISO 8655 tolerance limits), and digital signature fields. Data export supports CSV (for Excel analysis), PDF/A-1a (archival), and XML (for LIMS ingestion). Local storage retains ≥10,000 test records; optional cloud backup (AES-256 encrypted) enables remote review and trend analysis across multiple instruments. Software updates are delivered via signed firmware packages validated through SHA-256 checksum verification.

Applications

• Routine pipette performance verification in pharmaceutical QC labs conducting USP , , and ICH Q5C compliance testing.
• Equipment qualification (OQ/PQ) for automated liquid handlers and robotic workstations requiring traceable pipette validation.
• Training and competency assessment for laboratory personnel under CLIA and CAP accreditation frameworks.
• Reference lab services offering ISO/IEC 17025-accredited pipette calibration certificates with CMC statements.
• Method development labs evaluating tip-to-tip variability, viscous liquid handling, or volatile solvent dispensing accuracy.
• Manufacturers performing design verification and production lot testing per ISO 13485 quality management requirements.

FAQ

Does the ATMOS require external balance calibration before use?
No—the integrated high-precision weighing module is factory-calibrated with NIST-traceable weights and includes automatic internal calibration checks prior to each test sequence.
Can test results be imported directly into our LIMS?
Yes—XML export format is fully compatible with major LIMS platforms (e.g., LabWare, STARLIMS, Thermo SampleManager) via secure SFTP or direct API call.
Is the system suitable for Class A/B cleanroom environments?
Yes—IP54-rated enclosure, static-dissipative housing, and HEPA-filtered internal airflow meet ISO 14644-1 Class 5 operational requirements when installed with appropriate HVAC support.
How often must the ATMOS itself be recalibrated?
Annual recalibration by an ISO/IEC 17025-accredited service provider is recommended; internal diagnostics monitor sensor drift and alert users 30 days prior to due date.
Does it support validation documentation packages for FDA submissions?
Yes—includes IQ/OQ protocol templates, URS mapping, and 21 CFR Part 11-compliant electronic records with full audit trail export capability.