Thermo Scientific iSC-65 Multifunctional Autosampler

Overview

The Thermo Scientific iSC-65 Multifunctional Autosampler is an OEM-manufactured sample introduction system engineered specifically for high-throughput, trace-level elemental analysis using Thermo Scientific inductively coupled plasma mass spectrometry (ICP-MS) and optical emission spectrometry (ICP-OES) platforms. Designed and produced in Shanghai under strict Thermo Fisher quality governance protocols, the iSC-65 integrates seamlessly into laboratory workflows requiring reproducible, low-contamination sample handling across diverse matrix types — including environmental waters, clinical biofluids, semiconductor-grade reagents, and geological digests. Its core architecture employs precision stepper-motor-driven XYZ motion control, coupled with real-time obstruction sensing to prevent mechanical collision and ensure long-term operational reliability. Unlike generic third-party autosamplers, the iSC-65 implements instrument-specific fluidic timing, syringe actuation profiles, and wash-cycle synchronization calibrated to the pressure dynamics and dwell time requirements of Thermo’s iCAP series plasma sources — thereby minimizing memory effects, improving carryover performance (<0.005% for 10 µg/L Rh in 2% HNO₃), and maintaining analytical integrity across extended batch runs.

Key Features

• Precision XYZ robotic arm with integrated obstruction detection on all three axes — automatically halts motion and logs event upon physical interference, safeguarding both sample integrity and hardware longevity.
• Step Ahead™ rinse sequencing: initiates post-sample wash cycles concurrently with instrument data acquisition, reducing total cycle time by up to 28% versus sequential rinse architectures.
• Modular rack support accommodating four independently configurable racks per run — each accepting vial formats of 21, 24, 40, 60, or 90 positions (standard 12–16 mm OD); plus dedicated 10-position 50 mL round- or flat-bottom rack for large-volume standards or QC samples.
• Dual-channel, programmable rinse pump with Luer-lock fittings enabling independent flow-rate control (0.1–10 mL/min per channel) and chemical resistance to nitric, hydrochloric, and hydrofluoric acid-based wash solutions.
• Multi-color LED display providing at-a-glance status indication for power, communication link, rack presence, needle position, and error condition — fully accessible without software login.
• Full native integration with Qtegra ISDS Software v3.5+, supporting automated alignment routines, depth-per-vial calibration, multi-method scheduling, and audit-trail-enabled method versioning compliant with GLP and FDA 21 CFR Part 11 requirements.

Sample Compatibility & Compliance

The iSC-65 supports a broad range of sample container geometries and chemistries compatible with routine ICP-MS/OES operation: polypropylene and borosilicate glass vials (12–16 mm OD), including certified low-element trace vials (e.g., Savillex® PFA, SCP Science Ultra-Clean). It maintains compatibility with organic solvents (methanol, isopropanol), high-salt matrices (≥15% TDS), and viscous digestates when paired with appropriate syringe selection (e.g., 100 µL or 250 µL PTFE-coated plungers). The system complies with IEC 61326-1 (EMC for laboratory equipment), IEC 61010-1 (safety), and carries full CE marking. Its ACT Environmental Impact Factor Label — verified by My Green Lab — discloses quantified metrics across manufacturing energy use, packaging recyclability (>92% by weight), water consumption in production, and end-of-life material recovery pathways, supporting institutional ESG reporting and sustainable procurement policies.

Software & Data Management

Control and configuration are exclusively managed through Thermo Scientific Qtegra ISDS Software, eliminating standalone drivers or vendor-specific utilities. Within Qtegra, users define vial map coordinates, individual depth offsets per position (critical for variable-height vials), rinse solvent sequences, and dynamic rinse volume scaling based on prior analyte concentration. All method parameters — including needle immersion depth, aspiration/dispense speeds, rinse duration, and purge cycles — are stored as versioned, digitally signed objects. Audit trails record user ID, timestamp, parameter change, and reason code for every modification. Raw instrument logs and autosampler event logs (e.g., rack insertion, obstruction trigger, pump stall) are archived alongside spectral data in the Qtegra database, enabling full forensic reconstruction during regulatory audits or troubleshooting.

Applications

The iSC-65 is routinely deployed in accredited environmental testing laboratories performing EPA Methods 200.8 and 6020B; clinical reference labs conducting trace metal panels per CLIA and ISO 15189; semiconductor fabs monitoring ultra-trace metallic impurities in process chemicals (SEMI F57); and geochemical research facilities analyzing rare earth element distributions in rock digests. Its ability to maintain sub-picomolar detection stability over 200-sample batches — combined with programmable depth control for heterogeneous suspensions — makes it especially suited for high-precision isotope ratio measurements (e.g., U/Pb, Sr/Nd) where consistent nebulization efficiency is non-negotiable.

FAQ

Is the iSC-65 manufactured by Thermo Fisher or a third-party OEM?
The iSC-65 is produced under Thermo Fisher’s global OEM/ODM program in Shanghai, adhering to the same design specifications, component sourcing standards, and final functional test protocols applied to Thermo-branded autosamplers shipped from the US and UK facilities.
Does the iSC-65 support remote diagnostics or predictive maintenance?
Yes — via Ethernet connectivity and Qtegra’s embedded diagnostic server, users can access real-time pump pressure telemetry, motor current draw logs, and positional encoder feedback. These data streams feed into Thermo’s optional Instrument Health Monitoring (IHM) module for trend-based anomaly detection.
Can the iSC-65 be retrofitted onto legacy iCAP systems?
It is validated for iCAP PRO X/XP/XPS (2018+ firmware) and iCAP Qnova/MX series (with Qtegra v3.5+ installed); retrofitting to pre-2016 iCAP models requires hardware interface verification and may necessitate controller board upgrades.
What documentation is provided for regulatory compliance?
Each unit ships with a Certificate of Conformance, ACT Label Summary Report, Qtegra Part 11 Configuration Guide, and a complete set of IQ/OQ protocols aligned with ASTM E2500 and EU Annex 11 expectations.