Shine CIC-D180H High-Pressure Ion Chromatograph

Overview

The Shine CIC-D180H is a high-pressure ion chromatograph engineered for precision, speed, and robustness in routine and demanding anion and cation analysis. It operates on the fundamental principle of suppressed conductivity detection following high-efficiency ion exchange separation—leveraging high-pressure liquid delivery (up to 45 MPa) to drive mobile phase through sub-4 µm particle-size analytical columns. This architecture enables enhanced resolution, reduced analysis time, and improved sensitivity compared to conventional low-pressure IC systems. The instrument is designed for laboratories requiring reliable, reproducible quantification of trace-level ions—including F⁻, Cl⁻, NO₂⁻, Br⁻, NO₃⁻, PO₄³⁻, SO₄²⁻, Li⁺, Na⁺, NH₄⁺, K⁺, Mg²⁺, and Ca²⁺—in complex matrices such as environmental water, food extracts, pharmaceutical formulations, and industrial process streams.

Key Features

• High-pressure dual-piston reciprocating pump delivering stable flow from 0.001 to 15 mL/min with pressure capability up to 45 MPa, ensuring compatibility with ultra-high-resolution microbore and capillary columns.
• Integrated electrolytic eluent generator (EG) rated for sustained operation at elevated backpressures, eliminating manual eluent preparation and minimizing carbonate contamination.
• Zero-dead-volume high-pressure fittings and stainless-steel fluidic pathways minimize band broadening and ensure peak integrity across wide linear velocity ranges.
• Dual-directional column oven with refrigerator-style thermal insulation maintains precise temperature control (15–60 °C ±0.1 °C), critical for retention time stability and method transferability.
• Nitrogen-purged eluent reservoir system featuring a precision pressure regulator and continuous inert gas blanket to prevent CO₂ dissolution and pH drift during long-duration runs.
• Triple-platform intelligent monitoring: desktop workstation software, web-accessible mobile interface, and integrated touchscreen HMI enable real-time status visualization, remote diagnostics, and automated system validation.
• Comprehensive safety protocols including leak detection sensors with automatic pump shutdown, eluent volume tracking via capacitive level sensing, and hardware-enforced pressure interlocks.

Sample Compatibility & Compliance

The CIC-D180H supports aqueous sample injection volumes from 1–100 µL and accommodates filtration (0.22 µm or 0.45 µm) and dilution pretreatment steps common in regulated environments. It meets essential performance criteria outlined in ISO 10304-1 (water quality — determination of dissolved anions by liquid chromatography), ASTM D4327 (standard test method for anions in water by suppressed ion chromatography), and USP (conductivity of water for pharmaceutical use). Its architecture supports 21 CFR Part 11-compliant data handling when deployed with validated software modules, including electronic signatures, audit trails, and user access controls aligned with GLP and GMP laboratory practices.

Software & Data Management

The instrument is controlled via ShineChrom IC Suite—a modular, Windows-based application supporting method development, sequence management, peak integration (with baseline correction, retention time locking, and multi-point calibration), and report generation in PDF, CSV, and XML formats. Raw data files are stored in vendor-neutral .icd format with embedded metadata (instrument parameters, operator ID, timestamp, calibration history). The system supports LIMS integration via ASTM E1394 or HL7 messaging protocols and includes built-in tools for system suitability testing (SST), including resolution, tailing factor, and %RSD calculations per injection. All software updates undergo internal verification against ICH Q2(R2) guidelines for analytical procedure validation.

Applications

• Environmental monitoring: simultaneous quantification of inorganic anions and cations in drinking water, wastewater, and soil leachates at sub-ppb levels.
• Pharmaceutical quality control: residual chloride, acetate, and sulfate analysis in active pharmaceutical ingredients (APIs) and excipients per EP 2.2.38 and JP 2.10.
• Food & beverage safety: nitrate/nitrite profiling in processed meats, bromide in soft drinks, and iodide in dairy products.
• Battery electrolyte characterization: Li⁺, PF₆⁻, and TFSI⁻ analysis in lithium-ion battery research and production QC labs.
• Power generation: chloride and sulfate monitoring in ultrapure boiler feedwater to prevent corrosion in steam-cycle systems.

FAQ

What is the maximum recommended operating pressure for the CIC-D180H pump system?

The pump is rated for continuous operation up to 42 MPa, with a safety margin allowing transient peaks up to 45 MPa.
Does the system support gradient elution with multiple eluents?

Yes—the quaternary low-volume mixing module enables precise binary or ternary gradient formation using KOH, methanesulfonic acid, or carbonate/bicarbonate buffers.
Can the CIC-D180H be integrated into an existing LIMS environment?

It supports standard communication protocols including ASTM E1394 and OPC UA for bidirectional data exchange and automated result reporting.
Is column oven temperature stability validated per ISO/IEC 17025 requirements?

Yes—temperature uniformity and stability reports are included in the factory qualification package and can be re-verified using NIST-traceable PT100 probes.
What maintenance intervals are recommended for the electrolytic eluent generator?

Electrolytic membrane replacement is recommended every 12 months under typical usage; full EG performance verification should accompany each quarterly PQ check.