Agilent 7700x ICP-MS Inductively Coupled Plasma Mass Spectrometer (Refurbished)

Overview

The Agilent 7700x ICP-MS is a quadrupole-based inductively coupled plasma mass spectrometer engineered for high-sensitivity, interference-resistant elemental and isotopic analysis at trace and ultratrace levels (sub-atomic fg/g). It employs a robust argon plasma ion source operating at ~1 kW RF power, coupled with a triple-stage vacuum system and a high-transmission ion optics path. Its core innovation lies in the third-generation Octopole Reaction System (ORS3), which enables collision-mode operation using pure helium gas to suppress polyatomic interferences—including ⁴⁰Ar¹⁶O⁺, ⁴⁰Ar¹⁶O¹H⁺, and ⁴⁰Ar⁴⁰Ar⁺—without requiring reactive gases or complex tuning. This design delivers stable, reproducible detection limits of ≤0.1 fg/g for most elements in aqueous standards, with minimal matrix-induced signal suppression across diverse sample types.

Key Features

• Third-generation ORS3 collision cell with helium-only mode for universal polyatomic interference removal
• Digital RF generator with auto-matching capability ensuring plasma stability over extended run times
• High-efficiency sample introduction system compatible with standard nebulizers (e.g., MicroMist), cyclonic spray chambers, and optional desolvation modules
• Integrated MassHunter Data Acquisition and Analysis Software (v10.x or later), supporting method development, quantitative calibration (external/internal standardization), isotope ratio calculation, and time-resolved analysis
• Compact footprint (W × D × H: 84 × 74 × 76 cm) optimized for space-constrained laboratories
• Refurbished unit includes full electrical safety verification, vacuum integrity testing, mass calibration validation, and sensitivity/oxide/carbon cluster performance checks per Agilent’s certified refurbishment checklist

Sample Compatibility & Compliance

The Agilent 7700x accepts liquid samples introduced via concentric glass or PFA nebulizers, with compatibility extending to digested environmental waters, biological fluids (urine, serum), geological leachates, semiconductor-grade acids (HNO₃, HF), and high-purity reagents. It supports ASTM D5673 (trace metals in water), ISO 17294-2 (water quality – ICP-MS methods), and USP / (elemental impurities in pharmaceuticals). When deployed in regulated environments, the system—paired with validated MassHunter configurations—meets GLP and GMP documentation requirements, including electronic signatures, audit trails, and user-access controls aligned with FDA 21 CFR Part 11 Annex 11 principles.

Software & Data Management

Data acquisition and processing are performed using Agilent MassHunter Workstation Software, licensed for commercial use on the included workstation PC. The software provides real-time spectral visualization, automatic peak integration, multi-isotope dilution calibration, and customizable reporting templates exportable to PDF, CSV, or LIMS-compatible XML. Raw data files (.d format) retain full metadata—including instrument parameters, tune logs, and sequence history—for retrospective review. Optional add-ons include MassHunter Quantitative Analysis with IQ/OQ/PQ documentation packages and secure network deployment modules for centralized instrument management.

Applications

• Environmental monitoring: quantification of As, Cd, Pb, U, and rare earth elements in drinking water, wastewater, and soil extracts per EPA Method 6020B
• Geochemistry: high-precision isotope ratio analysis (e.g., Sr, Nd, Hf) in rock digests with external normalization
• Pharmaceutical QC: elemental impurity screening in active pharmaceutical ingredients (APIs) and excipients against ICH Q3D thresholds
• Electronics materials: detection of metallic contaminants (Na, K, Fe, Ni, Cu) in ultra-high-purity acids and silicon wafers at sub-ppt levels
• Clinical research: multi-element profiling in serum and whole blood for nutritional or toxicological studies

FAQ

Is this instrument fully refurbished and tested prior to shipment?
Yes. Each unit undergoes comprehensive functional verification including mass calibration, sensitivity assessment (using 1 ng/L Li/Y/Tl solution), oxide ratio (¹⁶⁰Gd¹⁶O⁺/¹⁶⁰Gd⁺), and background equivalent concentration (BEC) measurement. A full test report is provided with delivery.
What warranty coverage is included?
A 6-month limited hardware warranty is provided, covering defects in materials and workmanship under normal laboratory use. Exclusions include consumables (tubes, cones, torches), damage from improper installation or maintenance, and software licensing support beyond initial activation.
Can this system be integrated into an existing LIMS environment?
Yes. MassHunter supports ODBC and direct database export protocols compatible with major LIMS platforms. Custom API integration services are available upon request.
Are original Agilent service manuals and schematics included?
All units ship with digital copies of the Agilent 7700x Operator’s Guide, Maintenance Manual, and Safety Documentation. Physical hard copies may be supplied on request.
Does the system include a certified installation and qualification package?
Installation and basic operational qualification (OQ) can be arranged through authorized Agilent field engineers or qualified third-party service providers. Full IQ/OQ/PQ documentation kits are available as optional add-ons.