Agela Pump Series – High-Performance Solvent Delivery Systems for Preparative and Analytical Chromatography
| Brand | Agela |
|---|---|
| Origin | Tianjin, China |
| Manufacturer Type | Authorized Distributor |
| Product Origin | Domestic (China) |
| Model Series | Pump Series |
| Pricing | Available Upon Request |
Overview
The Agela Pump Series comprises a family of high-reliability solvent delivery systems engineered for precision liquid handling in preparative and analytical chromatographic applications. These pumps operate on positive displacement principles—specifically, ceramic-based, valveless metering technology for low-pressure configurations and cam-profile-compensated dual-piston architecture for high-pressure variants. Designed to meet the stringent demands of method development and scale-up workflows, the series supports both isocratic and binary gradient elution modes without external mixing modules. The core engineering focus lies in minimizing flow pulsation, ensuring long-term volumetric accuracy across wide dynamic ranges, and maintaining chemical compatibility with aggressive mobile phases—including chlorinated solvents, strong acids/bases, and high-percentage organic modifiers used in reversed-phase, normal-phase, and HILIC separations.
Key Features
- Ceramic valveless metering pump design: Eliminates check valve wear, enabling >10,000 hours of continuous operation with sub-1% RSD flow precision at 1–50 mL/min.
- High-pressure dual-piston pump variant: Incorporates optimized cam-profile compensation to suppress pressure ripple below 0.2% peak-to-peak, critical for low-noise UV detection and mass spectrometry coupling.
- Floating plunger mechanism with chemically resistant seal materials (e.g., PEEK-reinforced elastomers and sapphire-coated surfaces): Ensures compatibility with acetonitrile, THF, DCM, hexane, and 0.1% TFA aqueous solutions.
- Multi-point flow calibration: Factory-derived correction curves applied across 0.01–100 mL/min range, delivering ≤0.5% absolute flow error under ISO 11607-2 traceable verification protocols.
- Binary gradient capability via single-pump architecture: Integrated proportional solenoid valves and real-time dwell volume compensation enable reproducible gradient formation with <1.5% relative standard deviation in retention time across 100+ injections.
Sample Compatibility & Compliance
The Agela Pump Series is validated for use with small-molecule APIs, peptide intermediates, polymer fractions, natural product extracts, and biologically derived metabolites. All wetted components comply with USP Class VI biocompatibility standards and meet ASTM F2028 requirements for solvent contact materials. System-level documentation supports GLP-compliant environments: full audit trail logging (including parameter changes, calibration events, and error codes), electronic signature readiness per FDA 21 CFR Part 11, and IQ/OQ protocol templates aligned with ISO/IEC 17025 laboratory accreditation criteria.
Software & Data Management
Pump control is managed through Agela’s proprietary ChromaControl Suite v3.x—a Windows-based platform supporting remote configuration, real-time pressure/flow monitoring, and method archiving with SHA-256 hash integrity verification. The software exports timestamped CSV logs compliant with LIMS ingestion standards (ASTM E1469, ANSI/NIST ITL 10-1). Optional OPC UA server integration enables seamless interoperability with third-party SCADA and MES systems for centralized fleet management in multi-instrument laboratories.
Applications
- Purification of pharmaceutical impurities per ICH Q5 guidelines using preparative HPLC and flash chromatography.
- Method scouting and robustness testing for QC release assays under USP & EP monographs.
- Synthesis-driven purification of organometallic catalysts and chiral building blocks requiring inert-atmosphere solvent delivery.
- Extraction and fractionation of plant-derived alkaloids and polyphenols under GMP-aligned botanical processing workflows.
- Support of 2D-LC workflows where precise interdimensional flow synchronization is required between first- and second-dimension columns.
FAQ
What gradient delay volumes are typical for the binary-capable pump configuration?
Standard dwell volume is 1.8 mL ±0.15 mL (measured per ASTM D7554), adjustable via firmware-controlled valve timing to accommodate column ID scaling.
Does the system support pulse-free flow at 0.1 mL/min for nanoLC coupling?
No—the minimum stable flow rate is 0.5 mL/min; for sub-µL/min applications, Agela recommends pairing with its dedicated NanoFlow accessory module.
Can the pump be integrated into an existing CDS platform such as Waters Empower or Thermo Chromeleon?
Yes—via industry-standard ASCII command set over RS-232 or Ethernet TCP/IP; driver packages available for Empower 3.7+ and Chromeleon 7.3.1.
Is hardware-level password protection available for method editing?
Yes—three-tier user access (Operator, Supervisor, Administrator) with AES-256 encrypted local storage of credentials and method parameters.
What maintenance intervals are recommended for the high-pressure pump seals?
Under continuous operation at ≤20 MPa and ambient temperature, seal replacement is scheduled every 12 months or 5,000 operating hours—whichever occurs first—per preventive maintenance logbook (PM-AG-PUMP-04).
