Agela SPE-M08 Advanced Positive-Pressure Multi-Channel Solid Phase Extraction System
| Brand | Agela |
|---|---|
| Origin | Tianjin, China |
| Manufacturer Type | Authorized Distributor |
| Product Origin | Domestic (China) |
| Automation Level | Fully Automatic |
| Channel Count | 8 Independent Channels |
| Extraction Format | Cartridge-Based SPE |
| Flow Control | Per-channel adjustable and individually shutoff pneumatic flow regulation |
| Sample Capacity | Up to 8 samples simultaneously |
| Sample Loading Volume | Standard max. 50 mL |
| Dual-Pneumatic Circuit Design | One circuit for precise liquid flow control, one dedicated to cartridge drying/dehydration |
Overview
The Agela SPE-M08 is a fully automated, positive-pressure-driven multi-channel solid phase extraction system engineered for high-throughput, reproducible sample preparation in environmental, pharmaceutical, food safety, and clinical laboratories. Unlike vacuum-based SPE systems—whose flow rates are highly sensitive to cartridge clogging, solvent viscosity, and manifold seal integrity—the SPE-M08 employs regulated compressed air or nitrogen to apply consistent, programmable pressure across each SPE cartridge. This positive-pressure architecture ensures uniform flow dynamics, eliminates channel-to-channel variability, and enables precise kinetic control over loading, washing, and elution steps. The system supports standardized 1–6 mL SPE cartridges as well as 47 mm SPE membrane disks, accommodating diverse sorbent chemistries (C18, SCX, SAX, Florisil, silica, HLB, and custom-packed media). Its modular design integrates seamlessly into GLP-compliant workflows where method transferability, audit readiness, and inter-laboratory comparability are critical.
Key Features
- Fully automated 8-channel operation with independent pneumatic control per channel—each equipped with a precision needle valve for fine-tuned flow rate adjustment and complete on/off capability.
- Dual independent pneumatic circuits: one dedicated to sample/solvent delivery (0–100 kPa, digitally regulated), the other exclusively assigned to post-wash drying via inert gas purge—minimizing residual water carryover and improving analyte recovery consistency.
- Modular platform compatible with standard SPE cartridges (1–6 mL) and 47 mm membrane disks—no adapter kits required.
- Scalable sample volume handling: standard configuration supports up to 50 mL per channel; with the optional Large-Volume Loading Accessory (LVLA), the system accommodates aqueous matrices up to 5 L per channel using gravity-fed reservoirs coupled with pressure-assisted percolation.
- Robust aluminum alloy chassis with chemical-resistant surface coating; CE-marked pneumatic components compliant with ISO 8573-1 Class 3 for oil-free, particle-controlled gas supply.
Sample Compatibility & Compliance
The SPE-M08 is validated for use with EPA Methods 508.1, 525.3, 8270D, and 8081B, as well as ISO 17993:2021 (water quality—extraction of organic compounds by solid-phase extraction). It meets essential requirements for 21 CFR Part 11–ready operation when paired with Agela’s optional SPEControl Pro software (version 3.2+), supporting electronic signatures, user role-based access control, and immutable audit trails. All wetted materials—including tubing, valves, and manifold seals—are certified USP Class VI compliant and resistant to acetonitrile, methanol, dichloromethane, and 0.1 M HCl/NaOH. System performance verification protocols align with ASTM D5847–22 (Standard Practice for Quality Systems in Environmental Data Collection).
Software & Data Management
SPEControl Pro (sold separately) provides intuitive method programming, real-time pressure/flow monitoring per channel, and automated log generation in CSV and PDF formats. Each run generates a timestamped metadata file containing operator ID, method version, pressure setpoints, active channel map, and duration-stamped event markers (e.g., “Wash Step Initiated”, “Drying Cycle Completed”). Data files are stored locally on encrypted internal SSD and can be exported via USB or network share. Audit trail records retain full traceability for ≥10 years without manual intervention—fully satisfying FDA and EMA expectations for data integrity under ALCOA+ principles.
Applications
- Environmental analysis: trace-level extraction of PAHs, PCBs, organochlorine pesticides, and PFAS from surface water, wastewater, and soil leachates.
- Pharmaceutical QC: cleanup of biological matrices (plasma, urine) prior to LC-MS/MS quantification of APIs and metabolites per ICH M10 guidelines.
- Food safety testing: isolation of mycotoxins (aflatoxins, ochratoxin A) and veterinary drug residues from milk, honey, and cereal extracts.
- Clinical toxicology: high-recovery enrichment of benzodiazepines and opioids from forensic blood specimens with minimized phospholipid co-extraction.
- Method development labs: rapid screening of sorbent selectivity and elution solvent strength across eight parallel conditions—reducing optimization time by >70% versus sequential single-channel systems.
FAQ
Is the SPE-M08 compatible with third-party SPE cartridges and membranes?
Yes—mechanically and dimensionally compliant with all major OEM cartridges (e.g., Waters, Thermo Fisher, Phenomenex) and standard 47 mm SPE disk holders.
Can the system operate without a nitrogen generator?
Yes—compressed dry air (dew point ≤ −40°C) is acceptable; however, nitrogen is recommended for oxygen-sensitive analytes and long-term valve longevity.
What maintenance intervals are recommended for routine operation?
Pneumatic filter elements require replacement every 6 months under continuous use; needle valves should be inspected quarterly for particulate accumulation; no scheduled lubrication is required.
Does the LVLA accessory affect method validation status?
No—the LVLA is a hardware extension that maintains identical flow physics and pressure calibration; re-validation is limited to volume delivery accuracy (per ASTM D3695) and does not require full method requalification.
How is channel cross-contamination prevented during multi-sample runs?
Each channel features isolated fluid paths with non-return check valves and dedicated exhaust filtration; no shared manifolds or common waste lines exist between channels.
