Tianfeng TF-FZG-5 Freeze Dryer – Production-Scale Vacuum Lyophilizer
| Brand | Tianfeng |
|---|---|
| Origin | Shanghai, China |
| Manufacturer Type | Direct Manufacturer |
| Region Classification | Domestic (China) |
| Model | TF-FZG-5 |
| Instrument Type | Standard Shelf-Type Freeze Dryer |
| Application Scope | Production-Scale |
| Freeze-Drying Area | 5 m² |
| Ultimate Vacuum | ≤ 2.7 Pa |
| Condensate Capacity (24 h) | 100 kg |
| Cold Trap Temperature | ≤ −65 °C |
| Main Unit Dimensions | 4.5 × 2.1 × 3.6 m |
Overview
The Tianfeng TF-FZG-5 is a production-scale vacuum freeze dryer engineered for high-reliability lyophilization of heat-sensitive biological and food-grade materials. It operates on the principle of sublimation—where frozen water transitions directly from solid to vapor under controlled low-pressure and low-temperature conditions—thereby preserving structural integrity, bioactivity, volatile compounds, and nutritional profiles far more effectively than conventional thermal drying methods. Designed for continuous batch processing in GMP-aligned environments, this unit integrates a front-chamber rear-condenser architecture with an integrated refrigeration system, enabling stable operation across extended cycles. Its 5 m² shelf area supports scalable throughput while maintaining uniform temperature distribution across all five adjustable shelves (plus one auxiliary), making it suitable for pilot-to-production transition in food, nutraceutical, and functional ingredient manufacturing.
Key Features
- GMP-compliant construction: Freeze-drying chamber and shelves fabricated from electropolished 304 stainless steel with mirror-finish interior surfaces and zero-hygiene-dead-zone geometry.
- Integrated cold trap design: Stainless-steel coil condenser with ≤ −65 °C operating temperature and 100 kg/24 h ice capture capacity; available in monolithic or modular configurations per client specification.
- Precision shelf temperature control: Adjustable range from −45 °C to +80 °C, supporting both primary drying (sublimation) and secondary drying (desorption) phases with ±0.5 °C thermal stability.
- High-efficiency vacuum system: Equipped with ULVAC (formerly Unisys/Aktsu) high-vacuum pumps delivering ≤ 2.7 Pa ultimate pressure; optional multi-pump configurations available for accelerated pump-down and moisture removal.
- Intelligent process control: Omron PLC-based automation platform with industrial PC interface, Wi-Fi connectivity, and remote monitoring capability; supports up to 99 programmable drying recipes with real-time parameter override and step-jump functionality.
- Hygienic and service-oriented engineering: Front-access observation window with LED illumination; steam or immersion defrosting system; tool-free shelf removal; and modular refrigeration components using premium imported compressors and expansion valves.
Sample Compatibility & Compliance
The TF-FZG-5 accommodates diverse sample formats including bulk trays (up to 100 × 100 × 2 cm per shelf), vials, pouches, and irregularly shaped food matrices such as sliced fruits (e.g., yellow peach), enzymatic preparations (e.g., proteases), marine products, herbs, and functional nutraceuticals (e.g., royal jelly, ginseng extracts). All wetted surfaces comply with FDA 21 CFR Part 11–aligned data integrity requirements when paired with validated software logs. The system meets ISO 22000 food safety management benchmarks and supports validation protocols aligned with ASTM F2476 (Standard Guide for Validation of Freeze Drying Processes) and EU Annex 1 (Manufacture of Sterile Medicinal Products). Optional IQ/OQ documentation packages are available upon request.
Software & Data Management
Control firmware runs on a deterministic Omron NJ-series PLC platform interfaced with a ruggedized IPC running Windows IoT Enterprise. Data acquisition includes real-time logging of shelf temperature, chamber pressure, condenser temperature, vacuum pump status, and power consumption at user-defined intervals (1–60 sec). All operational events—including recipe execution, alarm triggers, manual interventions, and defrost cycles—are timestamped and stored locally with encrypted backup to network drives. Audit trails conform to ALCOA+ principles (Attributable, Legible, Contemporaneous, Original, Accurate, Complete, Consistent, Enduring, Available) and support GLP/GMP traceability requirements. Remote access enables secure off-site supervision via TLS-encrypted web portal or mobile dashboard.
Applications
This freeze dryer serves dual-purpose roles across regulated and non-regulated sectors: In food R&D and manufacturing, it enables preservation of organoleptic properties in fruits (e.g., yellow peach), vegetables, meats, seafood, seasonings, and instant meal components without caramelization or Maillard degradation. In bioprocessing and nutraceutical production, it stabilizes labile proteins (e.g., proteases), enzymes, probiotics, botanical extracts, and bee-derived actives—retaining conformational fidelity and reconstitution kinetics. Its shelf temperature flexibility also supports freeze-thaw cycle testing, cryo-concentration pre-processing, and low-temperature solvent removal in analytical sample preparation workflows.
FAQ
Is the TF-FZG-5 compliant with international food safety standards?
Yes—it adheres to ISO 22000 hygiene design principles, and its material contact surfaces meet EC 1935/2004 and FDA 21 CFR 170–189 requirements for food-contact equipment.
Can shelf configuration be customized for specific product trays or containers?
Absolutely—shelves can be supplied in either 304 stainless steel (electropolished, laser-cut) or extruded aluminum alloy (anodized, thermally optimized); spacing is fixed at 65 mm but total shelf count and dimensions are configurable.
What level of vacuum accuracy and repeatability does the system achieve during drying cycles?
The system maintains ≤ 2.7 Pa ultimate vacuum with pressure stability within ±0.3 Pa over 4-hour dwell periods, verified using calibrated capacitance manometers traceable to NIST standards.
Does the controller support electronic signatures and 21 CFR Part 11 compliance?
When deployed with validated software modules and role-based access controls, the system supports electronic signature enforcement, audit trail export, and change history retention required under FDA 21 CFR Part 11.
What is the typical lead time for delivery and installation support?
Standard units ship within 5–7 business days after order confirmation; field commissioning, IQ/OQ support, and operator training are offered globally through certified partners or Tianfeng’s direct technical team.
