Yarong RE-5250 Rotary Evaporator
| Brand | Yarong |
|---|---|
| Model | RE-5250 |
| Capacity | 50 L |
| Rotation Speed | 0–70 rpm |
| Temperature Control Range | Ambient to 99 °C |
| Temperature Accuracy | ±1 °C |
| Origin | Shanghai, China |
| Manufacturer | Yarong Instrument Co., Ltd. |
Overview
The Yarong RE-5250 Rotary Evaporator is an industrial-grade benchtop-to-pilot-scale purification system engineered for reproducible solvent removal, concentration, and recovery under reduced pressure. Based on the fundamental principle of rotary evaporation—where a rotating flask increases surface area while vacuum lowers boiling points—the RE-5250 enables efficient phase separation of thermally sensitive compounds without thermal degradation. Its 50 L working capacity positions it at the intersection of laboratory development and pilot-scale process validation, supporting scalable workflows in regulated environments including pharmaceutical process R&D, fine chemical synthesis, and natural product isolation. The system integrates core engineering features such as a frequency-controlled drive motor, digital PID temperature regulation, and a built-in vacuum control module—ensuring stable operation across extended run times typical of multi-hour batch processing.
Key Features
- 50 L evaporating flask capacity with standardized ISO-KF 50 or DN50 flange interface for compatibility with auxiliary condensers, cold traps, and vacuum manifolds
- Variable-speed rotation (0–70 rpm) via inverter-driven motor, enabling precise control over film thickness and heat transfer dynamics on the flask interior wall
- Digital dual-display interface showing real-time rotational speed and water/oil bath temperature with ±1 °C accuracy over 0–99 °C range
- Automated vertical lift mechanism for the heating bath, programmable for synchronized ascent/descent during start-up and shutdown to prevent bumping or overflow
- Integrated vacuum controller with pressure sensing and proportional solenoid valve actuation, supporting setpoint-based vacuum maintenance between 1–760 Torr (or mbar)
- Segmented vertical condenser with high-efficiency borosilicate glass construction; thermal performance calibrated to match that of a 3 m² conventional coil condenser under standard vapor load conditions
- Continuous feed and discharge ports fitted with PTFE stopcocks and quick-connect fittings, facilitating uninterrupted operation during multi-liter batch processing
Sample Compatibility & Compliance
The RE-5250 accommodates a broad spectrum of solvents—including water, ethanol, acetone, ethyl acetate, dichloromethane, and toluene—across pH 2–12 and viscosity ranges up to 500 cP. All wetted parts are constructed from borosilicate 3.3 glass (DIN ISO 3585), PTFE, and stainless steel 316L, ensuring resistance to corrosion and leachables. The unit complies with general safety requirements outlined in IEC 61010-1 for laboratory electrical equipment and meets CE marking criteria for electromagnetic compatibility (EMC Directive 2014/30/EU). While not certified for GMP manufacturing use out-of-the-box, its design supports integration into GLP-compliant workflows when paired with validated SOPs, audit-trail-capable data loggers, and 21 CFR Part 11–compliant software extensions.
Software & Data Management
The RE-5250 operates as a standalone instrument with embedded microcontroller logic and does not include proprietary PC software. However, analog outputs (0–10 V or 4–20 mA) are available for rotational speed and bath temperature signals, enabling connection to external SCADA systems, PLCs, or third-party data acquisition platforms (e.g., LabVIEW, Delta Tau, or Ignition). Optional RS-485 Modbus RTU communication allows remote parameter monitoring and basic command execution (start/stop, setpoint adjustment) when interfaced with compatible controllers. For regulatory traceability, users may deploy external USB or Ethernet-connected chart recorders to capture time-stamped operational logs aligned with internal quality management systems.
Applications
- Concentration of active pharmaceutical ingredients (APIs) and intermediates during downstream processing in compliance with ICH Q5 and Q7 guidelines
- Solvent recovery and reuse in fine chemical manufacturing, reducing VOC emissions and raw material costs
- Removal of low-boiling solvents from polymer solutions prior to gel permeation chromatography (GPC) analysis
- Dehydration of hygroscopic extracts in phytochemistry and nutraceutical R&D
- Crystallization initiation by controlled solvent depletion in chiral resolution processes
- Preparative-scale fractional distillation when coupled with Vigreux or spinning band columns
FAQ
What is the maximum recommended operating vacuum level for the RE-5250?
The system is rated for continuous operation down to 10 mbar (7.5 Torr); optimal performance is achieved between 20–100 mbar depending on solvent volatility and bath temperature.
Can the RE-5250 be used with oil baths above 100 °C?
No—the integrated heating bath is limited to 99 °C; for higher-temperature applications, external heated mantles or circulating oil baths with independent controllers must be employed.
Is the condenser cooled by circulating coolant or ambient air?
The standard configuration uses recirculating coolant (e.g., chiller or tap water); air-cooled variants are not offered due to insufficient thermal capacity for 50 L-scale evaporation.
Does the RE-5250 support automatic distillate collection switching?
Not natively; fraction collection requires integration with external automated fraction collectors via TTL or relay-triggered interfaces.
What maintenance intervals are recommended for long-term reliability?
Vacuum pump oil should be changed every 200 hours of operation; PTFE seals and gaskets inspected quarterly; condenser cleaned after each solvent class change to prevent cross-contamination.
