Chu Ding Technology CBS-C Computer-Controlled Fraction Collector

Overview

The Chu Ding Technology CBS-C Computer-Controlled Fraction Collector is an advanced, square-format liquid fractionation system engineered for precision integration into preparative chromatography and high-performance liquid chromatography (HPLC) workflows. Operating on a programmable X-Y mechanical stage, the CBS-C delivers fully automated, position-accurate tube alignment—enabling reliable sequential or triggered collection of eluent fractions based on time, droplet count, or analog UV/absorbance signal input (0–1000 mV). Its core architecture supports real-time synchronization with preparative peristaltic or syringe pumps, as well as HPLC detectors, making it a critical component in method-driven fraction isolation protocols across biomolecule purification, natural product isolation, and pharmaceutical process development.

Key Features

• Programmable XY-stage motion with auto-alignment to standardized tube racks (16-, 36-, 100-, or 169-position configurations supported via optional SP-36L expansion trays)
• Dual-mode analog input interface (0–1000 mV) for precise peak-triggered collection, compatible with standard UV-Vis, conductivity, and refractive index detectors
• Three independent collection modes: time-based (1 second to 9999 minutes), drop-count-based (1–9999 drops), and peak-threshold-based (user-defined mV threshold with adjustable slope sensitivity)
• Integrated waste trough with dedicated drainage path to prevent cross-contamination between runs
• Backlit blue LCD display with full Chinese-language menu navigation and real-time status feedback (method name, current tube index, elapsed time, remaining volume estimate)
• Non-volatile memory retaining up to 10 user-defined collection programs with automatic power-loss recovery and ≥10-year data retention
• RS232C serial interface compliant with industry-standard communication protocols for bidirectional control and logging via external PC

Sample Compatibility & Compliance

The CBS-C is chemically resistant to common organic solvents—including acetonitrile, methanol, chloroform, ethyl acetate, and tetrahydrofuran—as well as aqueous buffers across pH 2–12. All fluid-contact surfaces are constructed from chemically inert polymers (PP, PTFE-lined tubing paths) and stainless-steel guide rails. The system meets general laboratory safety requirements per IEC 61010-1 and is designed for use in ISO 17025-accredited testing laboratories. While not inherently 21 CFR Part 11-compliant, its RS232C interface and deterministic program execution support integration into validated environments when paired with audit-trail-enabled third-party software (e.g., LabArchives, Empower, or custom LIMS solutions).

Software & Data Management

The CBS-C operates standalone via front-panel controls but achieves full functionality when connected to a Windows-based host PC using the included proprietary control software. This application enables method creation, real-time monitoring of collection progress, export of timestamped CSV logs (including trigger events, tube indices, and detector voltage traces), and batch renaming of output directories. Raw collection metadata—including start/stop timestamps, active trigger mode, and analog input baseline values—is embedded in each exported file header. Software updates are distributed via secure download portal; no cloud connectivity or remote telemetry is implemented, preserving data sovereignty in regulated environments.

Applications

• HPLC and flash chromatography fraction harvesting for compound library generation and purity assessment
• Preparative-scale protein purification using FPLC systems with UV-monitoring feedback loops
• Metabolite isolation from plant extracts or fermentation broths under gradient elution conditions
• Quality control sampling during continuous-flow synthesis or inline reaction monitoring setups
• Automated solvent exchange and buffer exchange steps in nucleic acid or peptide processing workflows
• Method development studies requiring reproducible, multi-parameter fraction segmentation (e.g., overlapping time/peak windows)

FAQ

What tube rack configurations are natively supported?
The CBS-C accepts standard 100-tube rectangular racks (10 × 10) as default. Optional SP-36L trays (6 × 6) and modular 16- or 169-position plates can be installed without hardware modification.
Can the CBS-C interface with third-party HPLC data systems?
Yes—via RS232C, it accepts TTL-level trigger signals and transmits status codes. Integration with Agilent ChemStation, Waters Empower, or Shimadzu LabSolutions requires custom script mapping using their respective SDKs or macro engines.
Is the analog input calibrated to NIST-traceable standards?
The 0–1000 mV input channel is factory-calibrated against certified reference voltages; calibration certificates are available upon request for GLP/GMP documentation.
Does the system support fractional collection within a single peak?
Yes—using programmable “peak windowing,” users may define multiple sub-threshold zones (e.g., rising edge, apex, falling edge) to collect discrete segments of a single chromatographic peak.
What maintenance is required for long-term reliability?
Annual verification of XY-stage positioning accuracy and analog input linearity is recommended; no consumables beyond standard lab-grade tubing and tube racks are required.