Chu Ding Technology HSE-24A Circular Vacuum Solid Phase Extraction System

Overview

The Chu Ding Technology HSE-24A Circular Vacuum Solid Phase Extraction (SPE) System is an engineered benchtop platform designed for reproducible, high-throughput sample preparation in regulated and research laboratories. It operates on the fundamental principle of selective adsorption and elution—leveraging physicochemical interactions (e.g., reversed-phase, ion exchange, or hydrophilic-lipophilic balance) between analytes and solid sorbent materials packed in disposable cartridges. Unlike liquid–liquid extraction, SPE minimizes solvent consumption, eliminates emulsion formation, and significantly improves analyte recovery and matrix removal efficiency. The HSE-24A implements a centralized vacuum manifold architecture with uniform pressure distribution across all 24 ports, ensuring consistent flow rates and column equilibration—critical for method transferability and inter-laboratory comparability in compliance-driven workflows.

Key Features

• 24-position circular manifold with CNC-machined anodized aluminum body, offering dimensional stability and corrosion resistance under repeated solvent exposure
• Dual-seal O-ring design per port ensures leak-free operation at sustained vacuum levels up to 0.08 MPa (≈600 Torr), validated per ISO 22196 for sealing integrity
• Integrated stainless-steel 10 L collection reservoir with integrated drain valve and level indicator—compatible with aggressive solvents including acetonitrile, methanol, and dichloromethane
• No-fog vacuum chamber design prevents solvent vapor condensation and cross-contamination between adjacent channels during sequential or parallel processing
• Modular column adapter system supports universal SPE cartridge formats: 1 mL, 3 mL, 6 mL, and 12 mL tubes (13 mm and 25 mm OD), enabling method scalability from trace analysis to preparative isolation
• Low-profile footprint (Ø250 × 250 mm) optimizes fume hood or laminar flow cabinet integration without compromising ergonomic access to all ports
• Weight-optimized construction (4 kg net) facilitates mobility between analytical zones while maintaining mechanical rigidity during vacuum cycling

Sample Compatibility & Compliance

The HSE-24A is routinely deployed in laboratories adhering to ISO/IEC 17025, USP , and EPA Method 500/600 series protocols for environmental water analysis, pesticide residue testing (AOAC 2007.01), and pharmaceutical impurity profiling. Its inert wetted path—comprising stainless steel, PTFE, and silicone-free elastomers—ensures compatibility with acidic, basic, and oxidizing eluents without leaching or catalytic degradation. The system supports GLP-compliant documentation when paired with validated vacuum controllers (e.g., digital vacuum regulators with audit-trail logging). All structural components meet RoHS Directive 2011/65/EU material restrictions, and the stainless-steel reservoir complies with ASTM A240/A240M for 304-grade corrosion resistance.

Software & Data Management

As a hardware-only vacuum manifold, the HSE-24A does not include embedded firmware or proprietary software. It is fully compatible with third-party vacuum control systems that support analog 0–10 V or digital RS-485 interfaces—including those compliant with FDA 21 CFR Part 11 requirements for electronic records and signatures. Laboratories may integrate the unit into LIMS environments via programmable logic controllers (PLCs) or industrial I/O modules, enabling automated start/stop triggers synchronized with autosampler events or chromatographic run sequences. Calibration verification is performed using certified pressure transducers traceable to NIST standards; routine performance checks follow SOPs aligned with ISO/IEC 17025 Clause 6.4.

Applications

• Environmental analysis: Pre-concentration of trace-level PAHs, PCBs, and endocrine disruptors from surface water, wastewater, and soil extracts prior to GC-MS or LC-MS/MS quantification
• Food safety: Cleanup of mycotoxins (aflatoxin B1, ochratoxin A) and veterinary drug residues (fluoroquinolones, sulfonamides) from milk, honey, and cereal matrices
• Pharmaceutical QC: Isolation of active pharmaceutical ingredients (APIs) and genotoxic impurities from synthetic reaction mixtures and tablet dissolution media
• Clinical toxicology: Selective enrichment of opioids, benzodiazepines, and stimulants from urine and plasma samples under CLIA-waived or CAP-accredited workflows
• Forensic chemistry: High-recovery isolation of cannabinoids and novel psychoactive substances (NPS) from complex biological specimens

FAQ

Is the HSE-24A compatible with positive-pressure nitrogen manifolds?

Yes—the vacuum ports accept standard 1/4″ NPT male fittings; optional reverse-flow adapters are available for nitrogen-assisted elution or dry-down protocols.
Can the stainless-steel collection vessel be autoclaved?

No—autoclaving exceeds the thermal rating of the integrated silicone gaskets; chemical sterilization with 70% ethanol or 0.5% sodium hypochlorite is recommended.
What vacuum pump specifications are required for optimal performance?

A two-stage rotary vane pump capable of sustaining ≤5 mbar ultimate vacuum and ≥20 L/min free-air displacement is recommended for full 24-channel operation.
Does the system support method validation per ICH Q2(R2)?

Yes—its mechanical consistency enables robustness testing across variables including flow rate, dwell time, and cartridge batch lot; validation documentation templates are provided upon request.
Are replacement O-rings and column adapters available as spare parts?

Yes—genuine Chu Ding Technology spares (P/N: HSE-O-RING-KIT-24 and HSE-ADAPTER-UNIV) are stocked globally and shipped with ISO-certified calibration certificates.