Chu Ding Technology DG-12 Manual 12-Channel Solid Phase Extraction (SPE) Manifold

Overview

The Chu Ding Technology DG-12 Manual 12-Channel Solid Phase Extraction (SPE) Manifold is a precision-engineered vacuum-assisted sample preparation platform designed for reproducible, high-throughput solid-phase extraction of liquid samples in analytical laboratories. It operates on the fundamental principle of selective adsorption—where analytes are retained on solid-phase sorbent cartridges via hydrophobic, ionic, or polar interactions, while matrix interferences pass through under controlled vacuum-driven flow. Subsequent elution with appropriate solvents enables targeted recovery and concentration of target compounds prior to instrumental analysis (e.g., HPLC, GC, LC-MS). Unlike automated systems, the DG-12 employs manual vacuum regulation via integrated needle valves, granting users full control over flow dynamics across all 12 parallel channels—critical for method development, optimization of retention/elution kinetics, and handling diverse sample viscosities or particulate loads. Its compact footprint (165 × 125 × 175 mm), lightweight aluminum alloy frame, and corrosion-resistant PTFE fluid path ensure compatibility with aggressive organic solvents (e.g., methanol, acetonitrile, dichloromethane) and long-term stability in routine QC, environmental, food safety, and clinical research workflows.

Key Features

• 12 independent, individually adjustable PTFE-coated stainless steel ports with precision needle valves for fine-tuned flow control (0.1–30 mL/min per channel)
• Full PTFE wetted surfaces—including valve bodies, tubing connectors, and cartridge support plates—ensuring chemical inertness and minimizing analyte adsorption or leaching
• Modular design supports standard 1 mL, 3 mL, 6 mL, and 10 mL SPE cartridges; accommodates 16 mm OD collection tubes, 15 mL centrifuge tubes, and 40 mL glass vials without adapters
• Vacuum port rated for ≤0.1 MPa absolute pressure, compatible with standard lab vacuum pumps or house vacuum lines (recommended vacuum regulator for stable operation)
• Compact benchtop form factor (165 × 125 × 175 mm) and low mass (~2.0 kg) facilitate easy relocation and integration into fume hoods or laminar flow cabinets
• Optional expansion to 24- or 36-channel configurations available via modular stacking kits—maintaining identical flow control architecture and PTFE compatibility

Sample Compatibility & Compliance

The DG-12 manifold is validated for use with aqueous, alcoholic, and mildly acidic or basic liquid matrices—including drinking water, wastewater, fruit juice extracts, plasma supernatants, and tissue homogenates. It supports EPA Methods 508, 525.3, and 8270D for halogenated organics and PAHs; AOAC Official Methods for pesticide residue analysis in produce; and ISO 17025-aligned workflows requiring documented operator control over extraction parameters. While the device itself does not generate electronic records, its manual operation allows full traceability when used within GLP-compliant SOPs—operators record vacuum settings, elution volumes, and fraction collection times in laboratory notebooks or LIMS-integrated worksheets. All structural materials comply with RoHS Directive 2011/65/EU and meet USP Class VI biocompatibility requirements for PTFE components.

Software & Data Management

The DG-12 is a hardware-only platform with no embedded firmware, touchscreen interface, or proprietary software. This design eliminates calibration drift, cybersecurity vulnerabilities, and vendor lock-in—making it suitable for regulated environments where instrument qualification focuses solely on mechanical performance and material compatibility. Users maintain complete procedural autonomy: vacuum pressure is monitored externally using calibrated analog or digital gauges; flow rates are verified gravimetrically or volumetrically per ASTM D1193 Grade III water standards. Data generated during SPE (e.g., breakthrough volumes, recovery yields) are recorded manually or imported into validated third-party platforms such as LabWare LIMS, Thermo Fisher SampleManager, or custom Excel-based templates compliant with 21 CFR Part 11 when paired with electronic signatures and audit trails.

Applications

• Environmental monitoring: Extraction and preconcentration of polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and organochlorine pesticides from surface water and groundwater per EPA Method 525.3
• Food safety testing: Cleanup of QuEChERS extracts prior to GC-MS/MS analysis of multi-residue pesticides in fruits, vegetables, and cereals (AOAC 2007.01)
• Clinical toxicology: Isolation of basic drugs (e.g., amphetamines, opioids) and acidic metabolites (e.g., salicylic acid, ibuprofen) from human plasma and urine using mixed-mode cation/anion exchange cartridges
• Pharmaceutical QC: Removal of excipients and degradation products from dissolution samples prior to HPLC-UV quantification per USP <621>
• Forensic chemistry: Selective enrichment of cannabinoids and synthetic cathinones from oral fluid and hair digests using silica-based reversed-phase sorbents

FAQ

Is the DG-12 compatible with 10 mL SPE cartridges?
Yes—the cartridge support plate accepts standard 10 mL SPE columns with 15 mm diameter footprints; height clearance accommodates up to 120 mm tall cartridges.
Can I use this manifold under nitrogen purge instead of vacuum?
No—it is engineered exclusively for vacuum-driven flow; positive-pressure operation may compromise seal integrity and cause solvent leakage.
What vacuum pump specifications are recommended?
A two-stage diaphragm pump capable of sustaining ≥0.08 MPa vacuum at ≥20 L/min free-air displacement is optimal for uniform flow across all 12 channels.
Does the DG-12 include collection tubes or SPE cartridges?
No—these are supplied separately; the system is configured for universal compatibility with commercially available SPE cartridges and lab-standard tube formats.
How is cleaning and maintenance performed?
After each use, rinse all PTFE surfaces with methanol followed by deionized water; dry thoroughly before storage. Needle valves require no lubrication and are resistant to seizing when operated within specified torque limits.