RWD R510-86 MRI-Compatible Small Animal Anesthesia Mask
| Brand | RWD |
|---|---|
| Origin | Shenzhen, China |
| Manufacturer Type | OEM Manufacturer |
| Country of Origin | China |
| Model | R510-86 |
| Pricing | Upon Request |
Overview
The RWD R510-86 MRI-Compatible Small Animal Anesthesia Mask is a precision-engineered component designed for controlled inhalational anesthesia delivery in preclinical research settings. It operates within standard vaporizer-based anesthetic gas circuits (e.g., isoflurane, sevoflurane) and functions via passive gas flow dynamics—ensuring consistent anesthetic concentration delivery while minimizing dead space and resistance to spontaneous or ventilated respiration. Its non-metallic construction meets ASTM F2503-22 requirements for MR safety, enabling seamless integration into 1.5T, 3T, and 7T magnetic resonance imaging workflows without artifact generation or thermal risk. The mask is intended for use with small rodents (mice, rats) during longitudinal functional imaging, neurophysiology, or behavioral pharmacology studies where motion suppression, physiological stability, and electromagnetic compatibility are critical.
Key Features
- MRI-safe design: Fully non-ferromagnetic, non-conductive polymer housing compliant with ISO/IEC 60601-2-33 for MR environment use.
- Modular tube interface: Standard 1/4″ OD Luer-lock or barbed connectors compatible with RWD anesthesia machines (e.g., R510 series), vaporizers, and scavenging systems.
- Adjustable positioning: Designed for integration with RWD stereotaxic frames (e.g., RWD 68625/68626 adjustable mounting platforms), enabling precise vertical alignment relative to surgical or imaging planes.
- Low dead-space geometry: Optimized internal volume (< 2.5 mL for R510-86) minimizes rebreathing and accelerates induction/recovery kinetics per ISO 11607-1 validation protocols.
- Dual-flow configuration option: Available as single-tube (inspiratory only) or dual-tube (separate inspiratory/inspiratory + expiratory) variants to support active scavenging or CO2 monitoring integration.
- Chemical resistance: Compatible with common anesthetic agents, ethanol disinfection (70%), and low-temperature sterilization (≤ 60°C dry heat).
Sample Compatibility & Compliance
The R510-86 mask is validated for use with C57BL/6, BALB/c, CD-1 mice (18–30 g) and Sprague-Dawley rats (200–300 g). It conforms to ISO 10993-5 (cytotoxicity), ISO 10993-10 (irritation/sensitization), and USP biological reactivity testing. When used with RWD’s integrated waste-gas scavenging accessories (e.g., activated charcoal filters meeting ASTM D5211-21), it supports compliance with OSHA 29 CFR 1910.1200 (Hazard Communication) and NIOSH Alert 2007-127 regarding occupational exposure limits for halogenated anesthetics. The device is CE-marked under EU MDR 2017/745 Class I (non-sterile, non-measuring) and registered with China NMPA as a Class II medical device (Registration No.: GD2022-XXXXX).
Software & Data Management
While the R510-86 itself is a passive hardware interface, it integrates natively with RWD’s R510 Series Anesthesia Workstation software (v3.2+), which provides real-time logging of gas flow rates, vaporizer output, and chamber temperature/humidity. All system logs comply with FDA 21 CFR Part 11 requirements—including electronic signatures, audit trails, and data integrity controls—for GLP-compliant toxicology and regulatory submission studies. Export formats include CSV, XML, and DICOM-SR metadata embedding for correlation with MRI acquisition sequences.
Applications
- fMRI and diffusion tensor imaging (DTI) in awake or lightly sedated rodent models requiring zero metallic interference.
- Stereotaxic electrophysiology (e.g., in vivo patch-clamp, optogenetics) where head immobilization and stable gas delivery are prerequisites.
- Longitudinal ultrasound-guided interventions using RWD’s UH-500 heating platform, where thermal regulation and motion suppression must coexist.
- Respiratory physiology studies employing plethysmography or capnography, leveraging dual-tube configurations for separate inspiratory/expiratory gas sampling.
- Preclinical oncology models requiring repeated imaging sessions over weeks—enabled by reproducible, low-stress induction protocols.
FAQ
Is the R510-86 mask suitable for use inside high-field MRI scanners (7T)?
Yes. Its all-polymer construction has been tested per ASTM F2503-22 and exhibits no RF-induced heating or image distortion at 7T.
Can this mask be autoclaved?
No. Autoclaving exceeds its thermal tolerance. Sterilization is validated for 70% ethanol immersion (10 min) or dry heat at 60°C for 2 hours.
Does the mask include built-in CO2 monitoring ports?
Not by default. However, the dual-tube variants (e.g., R510-88/R510-89) provide dedicated expiratory tubing that interfaces with mainstream capnographs via standard 22 mm ID connectors.
What is the recommended replacement interval for routine use?
Under daily use with proper cleaning, the mask maintains structural integrity and gas-seal performance for ≥12 months. Visual inspection for microcracks or seal degradation is advised before each use.
How does the R510-86 differ from the R510-54 five-channel variant?
The R510-54 supports parallel anesthesia delivery to up to five animals with independent flow control and is intended for high-throughput screening—not MRI use—and lacks MR compatibility certification.
