Herxi TDZ5 Blood Bank Centrifuge

Overview

The Herxi TDZ5 Blood Bank Centrifuge is a CE-marked, ISO 13485-certified benchtop low-speed centrifuge engineered specifically for blood banking, transfusion medicine, and clinical laboratory workflows. It operates on the principle of sedimentation-based separation under controlled gravitational force (RCF), enabling reliable stratification of whole blood into packed red blood cells, buffy coat, and platelet-rich plasma—critical steps in component preparation, compatibility testing, and serological analysis. Designed to meet stringent requirements for biosafety and operational reproducibility, the TDZ5 integrates a high-torque brushless DC motor, precision microprocessor control, and a fully sealed 304 stainless steel centrifuge chamber. Its maximum speed of 4000 rpm and RCF of 2960 ×g are optimized for gentle yet effective separation of erythrocytes and leukocytes without hemolysis or platelet activation—key performance criteria defined in ASTM F2648 and CLSI GP44-A6 standards for blood bank instrumentation.

Key Features

• Brushless DC motor with integrated driver module (Infineon) and embedded microcontroller (Ingenic), delivering stable rotational output and <60 dB(A) acoustic emission during operation.
• Triple-stage damping system combined with precision-balanced rotor mounting to minimize vibration-induced sample resuspension and ensure consistent pellet integrity across repeated runs.
• TFT-LCD full-color display with dual-input interface (touchscreen + tactile keys), supporting real-time parameter adjustment—including rpm/RCF switching—without interrupting active centrifugation cycles.
• Biosafety-compliant swing-out rotor design featuring integrally molded silicone rubber gaskets (RoHS 2015/863 compliant), preventing aerosol escape during high-volume blood tube processing.
• Electromechanical auto-lock door mechanism with fail-safe interlock: lid engagement triggers immediate motor inhibition and status verification prior to acceleration initiation.
• 10-step programmable acceleration and deceleration profiles, allowing optimization for fragile samples such as platelet concentrates or cryoprecipitate preparations.
• Wide-voltage input option (100–230 V AC, 50/60 Hz) ensures stable performance in variable power environments common across regional blood centers and mobile collection units.

Sample Compatibility & Compliance

The TDZ5 accommodates standard blood banking consumables, including 15 mL conical tubes, 50 mL and 100 mL centrifuge bottles, vacuum collection tubes (2 mL and 5 mL), and 96-well microplates used in antibody screening assays. All rotor configurations—including 32 × 15 mL, 48 × 5 mL, and dual 96-well carriers—are validated for mechanical integrity at rated speeds and loads per ISO 15197 and EN 13612. The instrument’s structural architecture complies with IEC 61010-1:2010 safety requirements for laboratory equipment, while its manufacturing quality system adheres to ISO 13485:2016 for medical device production. CFDA registration documentation confirms conformity with China’s Medical Device Supervision and Administration Regulations, and all firmware operations support audit-trail generation for GLP/GMP-aligned workflow validation.

Software & Data Management

While the TDZ5 operates via an embedded real-time operating system (RTOS) without external PC dependency, it supports full traceability through non-volatile memory storage of up to 20 user-defined protocols—including speed, time, acceleration/deceleration ramp rates, and RCF targets. Each run logs timestamp, rotor ID, actual RCF achieved, and fault-event history (e.g., imbalance detection, thermal deviation). Optional RS-232 or USB-C interfaces enable export of run logs in CSV format for integration into LIMS platforms compliant with 21 CFR Part 11 when paired with appropriate electronic signature controls. Firmware updates are performed via secure authenticated download, preserving configuration integrity during version upgrades.

Applications

• Red blood cell (RBC) and white blood cell (WBC) separation for crossmatching and antigen typing.
• Preparation of platelet-rich plasma (PRP) and platelet-poor plasma (PPP) from whole blood units.
• Processing of donor and recipient serum samples for indirect antiglobulin test (IAT) and antibody identification panels.
• Centrifugal washing of RBCs prior to saline or albumin replacement in automated blood bank systems.
• High-throughput batch processing of EDTA, citrate, and heparinized specimens in immunohematology reference labs.
• Microplate-based agglutination assays requiring uniform pellet formation across 96-well formats.

FAQ

Is the TDZ5 suitable for processing infectious blood samples?
Yes—the sealed rotor chamber, RoHS-compliant gasketing, and Class II biosafety-rated construction meet WHO BSL-2 handling recommendations for human-derived biological materials.
Can the TDZ5 be validated for IQ/OQ/PQ protocols?
Yes—its ISO 13485 certification, documented metrological specifications (±50 rpm speed accuracy), and built-in event logging support formal qualification under ASTM E2500 and EU Annex 15 guidelines.
Does the instrument support regulatory compliance for FDA-regulated blood centers?
While not FDA-cleared as a standalone device, its design aligns with FDA 21 CFR Part 640 requirements for centrifuge performance in blood component manufacturing when operated within validated parameters.
What maintenance intervals are recommended for routine operation?
Rotor calibration and bearing inspection are advised every 12 months or after 10,000 cycles; cleaning protocols follow CLSI GP44-A6 guidance for decontamination between sample batches.
Are custom rotor adapters available for non-standard tube formats?
Yes—Herxi offers OEM-compatible adapter kits for specialized containers including pediatric blood tubes, gel separator tubes, and barcoded specimen vials upon request.