Hexion HR21M High-Speed Refrigerated Centrifuge
| Brand | Hexion |
|---|---|
| Origin | Hunan, China |
| Model | Hexion HR21M |
| Type | Floor-standing centrifuge |
| Category | High-speed refrigerated centrifuge (10,000–30,000 rpm) |
| Max. Speed | 21,000 rpm |
| Max. RCF | 53,741 × g |
| Max. Capacity | 6 × 500 mL |
| Temperature Range | −20 °C to +40 °C |
| Dimensions (W×D×H) | 840 × 730 × 960 mm |
| Control System | Mitsubishi PLC (compliant with EU EMC Directive 2014/30/EU & IEC 61131-2:2007), Weinview touchscreen (NEMA 4, CE certified) |
| Refrigeration | Imported non-CFC compressor with R404a refrigerant |
| Safety | RoHS-compliant silicone O-ring seal (EU Directive 2015/863), triple-layer steel protective housing, mechanical door lock, 3-stage damping system, imbalance/over-speed/over-temperature/under-voltage/over-voltage protection |
| Certifications | CFDA registration & manufacturing license, ISO 9001:2015, ISO 13485:2016 |
Overview
The Hexion HR21M is a floor-standing high-speed refrigerated centrifuge engineered for precision separation of biological, clinical, and pharmaceutical samples under controlled thermal conditions. It operates on the principle of sedimentation acceleration via rotational force—generating up to 53,741 × g at 21,000 rpm—to resolve particles differing in density, size, or shape across diverse suspension matrices. Designed for routine and demanding laboratory workflows, the HR21M integrates robust thermal management, real-time parameter monitoring, and fail-safe mechanical architecture to ensure reproducible pelleting, layering, or clarification outcomes. Its compliance with ISO 13485:2016 and CFDA regulatory requirements positions it for use in quality-controlled environments aligned with GLP and GMP frameworks.
Key Features
- High-torque brushless AC frequency drive motor delivering stable rotational performance with acoustic noise <65 dB(A) at maximum speed—optimized for shared laboratory spaces.
- Advanced refrigeration system featuring an imported hermetic compressor and environmentally compliant R404a refrigerant, enabling precise temperature control from −20 °C to +40 °C during active centrifugation; includes pre-cooling, standby cooling, and automatic defrost functions.
- Triple-stage composite damping system combined with asymmetric counterbalance detection and dynamic imbalance compensation to suppress vibration, minimize sample resuspension, and extend rotor service life.
- Intuitive human-machine interface with a 7-inch Weinview touchscreen (NEMA 4 rated), supporting multilingual operation (English, Chinese), real-time graphical display of speed ramping profiles, RCF accumulation curves, and thermal response trends.
- Mechanical interlocked lid with auto-engaging latch mechanism meeting IEC 61010-2-020 safety standards; reinforced stainless-steel centrifuge chamber and three-layer steel front shield provide structural integrity and containment assurance.
- RoHS 2015/863-compliant silicone elastomer sealing ring integrated into all biocontainment angle rotors to prevent aerosol leakage during high-speed operation—critical for BSL-2 compatible workflows.
Sample Compatibility & Compliance
The HR21M accommodates a broad range of primary and secondary containers via interchangeable angle rotors fabricated from aerospace-grade forged aluminum and certified polyamide fiber adapters. Compatible vessels include 1.5 mL microcentrifuge tubes, 15–50 mL conical tubes, 100–1000 mL bottles, and custom-format cartridges. All rotors undergo static and dynamic balancing per ISO 21501-4 and are validated for cyclic loading endurance exceeding 10,000 runs at rated speed. The instrument meets electromagnetic compatibility (EMC) requirements under EU Directive 2014/30/EU and carries full CE marking. Regulatory documentation includes CFDA Class II medical device registration (for in vitro diagnostic sample preparation), ISO 9001:2015 quality management certification, and ISO 13485:2016 certification for design and manufacturing controls—supporting audit readiness for FDA 21 CFR Part 820 and Annex 11-aligned data integrity assessments.
Software & Data Management
The embedded control firmware supports storage of up to 16 user-defined protocols with editable parameters—including acceleration/deceleration ramp rates (10-step programmable), hold times, temperature setpoints, and rotor identification codes. Each run logs timestamped metadata (start time, final speed, actual RCF, cavity temperature history, fault flags) into non-volatile memory. Audit trail functionality records operator ID (via optional RFID badge integration), parameter modifications, and emergency stop events—meeting ALCOA+ principles for electronic records under 21 CFR Part 11 when deployed with validated networked data export modules. Export formats include CSV and PDF reports compatible with LIMS ingestion.
Applications
- Isolation of subcellular organelles (mitochondria, lysosomes, nuclei) from mammalian tissue homogenates.
- Clarification and concentration of viral vectors (AAV, lentivirus) and exosomes in bioprocess development.
- Routine purification of plasmid DNA, RNA, and protein complexes from bacterial and eukaryotic lysates.
- Preparative separation of blood components including PBMCs, platelet-rich plasma (PRP), and serum-derived extracellular vesicles.
- Stability testing of nanoparticle suspensions and colloidal formulations under variable thermal stress conditions.
FAQ
What certifications does the HR21M hold for international laboratory use?
The unit is CE-marked, complies with IEC 61010-1 and IEC 61010-2-020 for electrical safety, and carries ISO 9001:2015 and ISO 13485:2016 certifications. CFDA registration supports its deployment in clinical sample processing within China; additional regional conformity (e.g., UKCA, ANVISA) requires local representative validation.
Can the HR21M maintain temperature stability during extended high-speed runs?
Yes—the dual-stage refrigeration circuit and insulated chamber design enable ±1.5 °C thermal consistency over continuous 60-minute runs at 21,000 rpm and −10 °C setpoint, verified per ISO 13485 clause 7.5.11.
Are rotors traceable and lifetime-monitored?
Each rotor bears a unique laser-engraved serial number linked to a factory-calibrated logbook documenting cumulative run hours, maximum speed history, and maintenance intervals. Rotors are not interchangeable across models without recalibration.
Does the system support remote monitoring or integration with lab automation platforms?
Standard RS-232 and optional Ethernet interfaces allow bidirectional communication using Modbus RTU/TCP protocols. Integration with LIS/LIMS systems requires configuration by authorized Hexion application engineers.
What is the warranty coverage and service response protocol?
Hexion provides a 24-month parts-and-labor warranty inclusive of on-site technician dispatch within 72 business hours in Tier-1 metropolitan areas. Extended service contracts include quarterly preventive maintenance, rotor calibration verification, and software update assurance.
