TissueGnostics TissueFAXS 8.0 Tissue and Cell Quantitative Analysis System
| Brand | TissueGnostics |
|---|---|
| Country of Origin | Austria |
| Manufacturer Type | Original Equipment Manufacturer (OEM) |
| Import Status | Imported |
| Model | TissueFAXS 8.0 |
| Pricing | Available Upon Request |
Overview
The TissueGnostics TissueFAXS 8.0 is a high-throughput, automated tissue and cell quantitative analysis system engineered for precision digital pathology workflows in academic research, clinical trial support, and translational medicine laboratories. Built upon a robust slide-scanning platform integrated with advanced image analytics, the system employs wide-field fluorescence and brightfield microscopy combined with motorized XYZ-stage control and hardware-synchronized multi-channel acquisition. Its core architecture supports whole-slide imaging (WSI) at up to 40× objective magnification, enabling pixel-accurate spatial mapping of biomarker expression, cellular morphology, and tissue architecture. Unlike conventional static image analyzers, TissueFAXS 8.0 implements dynamic focus tracking, real-time exposure optimization, and hardware-accelerated tile stitching—ensuring consistent signal fidelity across heterogeneous tissue sections. The system is designed for compliance with ISO 15189 and CLIA-aligned laboratory practices, supporting audit-ready metadata logging and DICOM-SR–compatible annotation export.
Key Features
- Redesigned modular user interface with workflow-oriented tab navigation—preconfigured panels for preview, acquisition, focus calibration, and batch processing reduce cognitive load and accelerate operator onboarding.
- Enhanced Z-stack acquisition engine featuring intuitive dual-threshold histogram controls, real-time depth visualization, and interactive virtual 3D rendering along X- and Y-axes; supports export of Z-series stacks in standardized *.ims format compatible with Imaris, Bitplane, and other 3D reconstruction platforms.
- Camera-agnostic label scanning capability—eliminates dependency on proprietary imaging sensors; leverages existing system cameras for barcode/QR code reading during slide loading, with configurable read resolution (2.5× or 5× optical zoom) and reflectance-mode prioritization to minimize transmission-artifact interference.
- Integrated Deep Neural Network (DNN)-based tissue detection module trained on multi-stain, multi-species histological datasets—including H&E, IHC, IF, and multiplex immunofluorescence—enabling adaptive segmentation without manual parameter tuning or stain-specific calibration.
- Automated focus profile generation per slide region, with optional auto-save of focus maps and channel-specific focus offset compensation to maintain z-axis consistency across multi-layer acquisitions.
Sample Compatibility & Compliance
TissueFAXS 8.0 accommodates standard glass slides (1 × 3 inches), including charged, APES-coated, and electrostatically enhanced substrates. It supports formalin-fixed paraffin-embedded (FFPE) and frozen sections up to 10 µm thickness, as well as cytology smears and tissue microarrays (TMAs). All acquisition parameters—including exposure time, gain, LED intensity, and z-step interval—are logged in machine-readable JSON metadata embedded within exported TIFF/OME-TIFF files. The software complies with FDA 21 CFR Part 11 requirements for electronic records and signatures when deployed with validated IT infrastructure, and supports GLP/GMP-aligned audit trails via timestamped operator actions, configuration changes, and result exports. Validation documentation—including IQ/OQ/PQ protocols—is available upon request for regulated environments.
Software & Data Management
The TissueFAXS 8.0 software suite operates on Windows 10/11 64-bit platforms and integrates natively with TissueQuest and StrataQuest analysis modules for single-cell phenotyping, spatial statistics, and neighborhood interaction modeling. Raw image data is stored in OME-TIFF format with embedded EXIF and OMERO-compatible metadata headers. Batch processing pipelines support parallel execution across CPU and GPU resources, with configurable job queuing and priority scheduling. Export options include CSV-based morphometric tables, GeoJSON spatial annotations, and DICOM-SR structured reports for PACS integration. All user sessions generate immutable log files compliant with ISO/IEC 17025 traceability standards, recording instrument state, environmental sensor readings (if connected), and software version fingerprints.
Applications
- Quantitative assessment of tumor-infiltrating lymphocytes (TILs) in immuno-oncology studies using multiplex IF panels.
- Spatial profiling of protein co-expression patterns in neurodegenerative disease models.
- Automated grading of fibrosis extent and collagen distribution in liver/kidney biopsies.
- High-content screening of drug-induced morphological changes in 3D organoid cultures.
- Validation of AI-derived biomarkers against ground-truth pathologist annotations in retrospective cohort studies.
FAQ
Does TissueFAXS 8.0 require a dedicated camera for barcode scanning?
No—it utilizes the system’s existing fluorescence or brightfield camera for label reading, eliminating the need for add-on hardware.
Can Z-stack data be exported for external 3D rendering?
Yes—Z-series acquisitions are exportable in Imaris-compatible *.ims format, preserving voxel geometry and channel metadata.
Is the DNN tissue detection model customizable for proprietary stains?
The base model is pre-trained and fixed; however, TissueGnostics offers custom model development services under NDA for institution-specific training datasets.
What file formats are supported for downstream analysis?
OME-TIFF (primary), TIFF, JPEG2000, and CSV; annotation layers export as GeoJSON or DICOM-SR.
How is software validation handled in regulated labs?
Comprehensive IQ/OQ/PQ documentation packages—including test scripts, acceptance criteria, and evidence templates—are provided for internal validation by qualified personnel.
