Hanuo HX-050 Super-Low-Temperature Circulating Chiller

Overview

The Hanuo HX-050 Super-Low-Temperature Circulating Chiller is a precision-engineered thermal management system designed for laboratory and pilot-scale applications requiring stable, programmable temperature control across an extended range of –40 °C to +105 °C. Built on a dual-stage cascade refrigeration architecture with environmentally compliant R-404A/R-23 mixed-refrigerant circuitry, the HX-050 delivers consistent thermal output under variable load conditions—critical for exothermic reaction control, cryogenic sample conditioning, and high-temperature material testing. Its stainless-steel bath reservoir and corrosion-resistant circulation path ensure long-term compatibility with water, ethylene glycol/water mixtures, silicone oils, and other non-aggressive heat-transfer fluids. Unlike single-stage chillers limited to –20 °C or above, the HX-050 maintains sub-zero stability without auxiliary dry-ice or liquid nitrogen supplementation—reducing operational complexity and consumable dependency in regulated environments.

Key Features

• Wide operational range: –40 °C to +105 °C with ≤±0.1 °C temperature stability (measured at bath sensor, 30-min dwell at setpoint)
• Dual-mode digital temperature display: 0.1 °C resolution for general operation; switchable 0.01 °C resolution for calibration-sensitive workflows
• High-flow external circulation: 18 L/min maximum flow rate at ≤2.5 bar pressure, supporting multi-instrument distribution via manifold systems
• Integrated PID controller with auto-tuning capability and ramp/soak programming (up to 10 segments)
• Robust construction: 304 stainless-steel bath (50 L capacity), insulated cabinet with low-thermal-conductivity polyurethane foam (≥50 mm thickness)
• Safety protections: Over-temperature cutoff, low-level fluid alarm, compressor high-pressure shutdown, and dry-run prevention for pump
• Front-panel USB port and RS-485 interface for remote monitoring and integration into centralized lab automation platforms

Sample Compatibility & Compliance

The HX-050 is compatible with a broad spectrum of laboratory equipment requiring external temperature control—including rotary evaporators, spectrophotometer cells, calorimeters, vacuum jacketed reactors, and analytical column ovens. Its fluid path meets ISO 8573-1 Class 4 purity requirements for compressed-air–free operation and is certified for use with USP-grade glycol solutions per USP environmental control guidelines. While not intrinsically rated for hazardous locations, the unit complies with IEC 61010-1:2010 (Ed. 3) safety standards for electrical equipment used in laboratory environments. Documentation packages include factory calibration certificates traceable to NIM (National Institute of Metrology, China) and optional IQ/OQ protocols aligned with GLP and GMP Annex 15 expectations.

Software & Data Management

Standard firmware supports real-time temperature logging at user-defined intervals (1–600 seconds) with internal storage for ≥30 days of data (timestamped, CSV-exportable via USB). Optional HanuoLink™ PC software (Windows 10/11) enables graphical trend analysis, alarm event tagging, and export to LIMS-compliant formats (ASTM E1384, ASTM E2500). Audit trail functionality records all parameter changes—including operator ID (via login), timestamp, and pre-/post-value—meeting FDA 21 CFR Part 11 requirements when deployed with Windows domain authentication and electronic signature modules. Remote access is supported via Modbus RTU over RS-485 for integration into SCADA or building management systems.

Applications

• Low-temperature synthesis: Controlled crystallization of APIs below –20 °C; Grignard and organolithium reaction quenching
• Material science: Thermal cycling of polymers and composites per ASTM D696 and ISO 11359
• Pharmaceutical QC: Dissolution apparatus temperature regulation (USP , ) and stability chamber preconditioning
• Biotechnology: Cold-stage incubation support for cryo-microscopy and enzyme kinetics assays
• Electronics testing: Thermal stress screening of PCBs and semiconductors per JEDEC JESD22-A104
• Calibration labs: Reference bath stabilization for thermometer and RTD verification per ISO/IEC 17025

FAQ

What refrigerants does the HX-050 use, and are they compliant with current environmental regulations?
The HX-050 employs a cascade system using R-404A (high-stage) and R-23 (low-stage), both approved under the EU F-Gas Regulation (No. 517/2014) for laboratory chiller applications until 2030. Refrigerant charge is fully sealed and serviceable only by certified technicians.
Can the HX-050 maintain –40 °C while circulating fluid through a 10-meter external loop with 1.5 kW heat load?
Yes—under nominal ambient conditions (≤25 °C, ≤60% RH), the HX-050 sustains –40 °C at the bath with ≤1.2 kW continuous heat rejection. For higher loads, optional air-cooled condenser upgrades or chilled-water assist kits are available.
Is the bath volume truly 50 L usable, or does it include structural displacement?
The 50 L specification refers to net fluid capacity—the volume measurable between minimum and maximum fill lines, verified hydrostatically during final QA.
Does the unit support external PT100 input for process temperature feedback control?
Yes—via optional analog input module (0–10 V or 4–20 mA), enabling cascade control where the chiller regulates based on a remote process sensor rather than internal bath temperature.
What maintenance intervals are recommended for optimal long-term performance?
Compressor oil and filter replacement every 24 months; refrigerant leak check annually; bath fluid exchange every 12 months (or per fluid manufacturer’s specification); full calibration verification every 18 months.