Yoke ASK200 Automated Dilution and Standard Preparation Workstation
| Brand | Yoke |
|---|---|
| Origin | Shanghai, China |
| Manufacturer Type | Manufacturer |
| Country of Origin | China |
| Model | ASK200 |
| Price Range | USD 140 – 70,000 |
Overview
The Yoke ASK200 Automated Dilution and Standard Preparation Workstation is an integrated liquid handling platform engineered for high-precision, trace-level standard solution preparation in regulated and research-intensive laboratory environments. It operates on gravimetric and volumetric dilution principles, combining precision positive-displacement syringe pumping with closed-system fluidics to deliver reproducible serial dilutions, multi-point calibration curves (e.g., 5–12 points), mixed standard solutions, and aliquot dispensing—without manual pipetting or open-bench exposure. Designed specifically for compatibility with downstream analytical instrumentation—including GC, LC, ICP-OES, ICP-MS, AAS, and UV-Vis spectrophotometers—the ASK200 ensures metrological traceability in sample preparation workflows where accuracy, linearity, and contamination control are critical. Its architecture supports ISO/IEC 17025-compliant method validation and aligns with USP , CLSI EP26-A, and GLP documentation requirements for standard preparation.
Key Features
- Integrated 10.1-inch industrial touchscreen interface with intuitive graphical workflow editor—enabling rapid creation, parameterization (solvent selection, target concentration, dilution factor, volume per point), and one-click execution of single-analyte standards, multi-analyte mixed standards, or full calibration curves.
- Light-tight enclosure with activated carbon gas filtration system—minimizing photodegradation of light-sensitive analytes (e.g., nitrosamines, peroxides, certain pesticides) and reducing solvent vapor exposure during unattended operation.
- Dual-path corrosion-resistant fluidic path: PTFE-coated DuPont™ tubing and air-gap liquid transfer technology isolate the precision syringe pump from aggressive reagents (e.g., 98% H₂SO₄, concentrated NaOH, acetonitrile, chloroform), extending pump lifetime and eliminating cross-contamination.
- Imported German high-accuracy syringe pump with programmable resolution down to 0.3 µL (0.0003 mL); volumetric repeatability ≤0.1% RSD (measured at 5.000 mL with deionized water per ISO 8655-5).
- Closed-loop environmental monitoring: real-time pressure sensing and liquid level detection confirm aspiration/dispense completion and prevent dry-run errors or bubble formation.
Sample Compatibility & Compliance
The ASK200 accommodates aqueous, organic, and mixed-phase liquids across pH 0–14 and viscosity up to 20 mPa·s. It supports certified reference materials (CRMs), matrix-matched standards, and stability-indicating dilutions required by EPA Method 525.3 (SVOCs), ISO 17294-2 (ICP-MS multi-element calibration), and AOAC 2012.01 (pesticide residue analysis). All hardware components comply with CE Machinery Directive 2006/42/EC and RoHS 2011/65/EU. Data integrity features—including electronic signatures, audit trail logging, and immutable method storage—support adherence to FDA 21 CFR Part 11 and EU Annex 11 for computerized systems in GxP environments.
Software & Data Management
The embedded firmware includes a method library with version-controlled storage (≥1,000 methods), automatic timestamped preparation logs, and PDF report generation (including lot numbers, operator ID, ambient temperature/humidity, raw volume data, and correlation coefficients). Export formats include CSV and XML for LIMS integration. All preparation events are time-stamped, user-attributed, and tamper-evident. Audit trails record method edits, run initiation, error alerts, and calibration events—retained for ≥36 months per internal retention policy.
Applications
- Environmental labs: preparation of EPA 8270D/8082A stock dilutions for semi-volatile and non-volatile organic compounds; trace metal calibration sets for ICP-MS analysis of drinking water matrices.
- Food safety testing: multi-residue pesticide and veterinary drug standard curves for LC-MS/MS quantification; heavy metal (Pb, Cd, As, Hg) calibration series compliant with EU Commission Regulation (EU) No 2023/915.
- Pharmaceutical QC: working standard preparation for dissolution testing (USP ) and impurity profiling (ICH Q2(R2)); buffer and placebo diluent formulation under cGMP Annex 15.
- Public health and CDC-equivalent institutes: standardized dilution of biological reference materials for ELISA and PCR assay calibration; trace element reference solutions for nutritional surveillance programs.
FAQ
Does the ASK200 support ISO/IEC 17025 method validation documentation?
Yes—automated generation of preparation records includes uncertainty estimates derived from pump specification, volumetric tolerance, and CRM certificate values.
Can the system be integrated into an existing LIMS or ELN?
Yes—via configurable RESTful API or scheduled CSV export; authentication supports LDAP and SAML 2.0.
What maintenance is required for long-term accuracy?
Syringe pump recalibration every 6 months (traceable to NIST SRM 2192); PTFE tubing replacement every 12 months or after 5,000 cycles.
Is remote monitoring supported?
Yes—web-based status dashboard accessible via secure TLS 1.3 connection; email/SNMP alerts for completion, error, or low-reagent conditions.
How does the ASK200 handle viscous or volatile solvents?
Pre-wet priming, adjustable aspiration speed, and vapor-tight sealing minimize evaporation loss and ensure consistent delivery of solvents such as DMSO, glycerol, or ether-based mixtures.
