Thermo Scientific GENESYS 180 UV-Vis Spectrophotometer
| Origin | USA |
|---|---|
| Manufacturer Type | Authorized Distributor |
| Origin Category | Imported Instrument |
| Model | GENESYS 180 |
| Price Range | USD 0–7,499 (FOB) |
| Optical Design | Double-Beam |
| Detector | Photodiode Array (PDA) |
| Wavelength Range | 90–1100 nm |
| Wavelength Selection | Manual (with touchscreen navigation) |
| Spectral Bandwidth | 2 nm |
| Wavelength Accuracy | ±0.5 nm |
| Stray Light | < 1.0% T |
Overview
The Thermo Scientific GENESYS 180 UV-Vis Spectrophotometer is a double-beam, photodiode array (PDA)-based spectrophotometer engineered for precision absorbance, transmittance, and concentration measurements across the deep ultraviolet to near-infrared spectrum (90–1100 nm). Its optical architecture employs a stable xenon flash lamp—rated for 5–7 years of typical laboratory use—eliminating warm-up delays and spectral drift associated with deuterium/tungsten lamp systems. The double-beam configuration continuously corrects for source intensity fluctuations and solvent or cuvette baseline variations in real time, enabling high reproducibility in kinetic studies, multi-sample comparative assays, and matrix-matched quantitation. Designed for ISO/IEC 17025-compliant laboratories, the instrument meets core performance criteria outlined in ASTM E275, USP , and ISO 6327 for photometric accuracy and wavelength verification.
Key Features
- Double-beam optical path with real-time reference beam compensation for enhanced baseline stability and reduced measurement variability
- Xenon flash lamp with >10⁹ flash lifetime, delivering consistent spectral output from 90 nm (deep UV) through 1100 nm without lamp alignment or warm-up periods
- 7-inch capacitive touchscreen interface, glove-compatible and chemically resistant, supporting intuitive method navigation, calibration workflows, and spectral preview
- Integrated Wi-Fi module compliant with IEEE 802.11n for secure, encrypted data transfer to networked LIMS or cloud-based storage (TLS 1.2+)
- Large sample compartment accommodating up to eight 10-mm pathlength cuvettes via standard 8-position rotating cell holder—optimized for batch analysis and QC throughput
- 2 nm spectral bandwidth ensuring adequate resolution for narrow absorption bands while maintaining signal-to-noise ratio per ICH Q2(R2) guidelines
- Wavelength accuracy of ±0.5 nm verified against NIST-traceable holmium oxide and didymium filters; stray light <1.0% T at 220 nm (NaI) and 340 nm (NaNO₂)
Sample Compatibility & Compliance
The GENESYS 180 supports standard quartz, glass, and plastic cuvettes (1–50 mm pathlength), microvolume adapters (including 1 µL capillary cells), and solid-sample reflectance accessories (optional). Its optical design minimizes photodegradation risk during repeated scans due to pulsed xenon illumination—critical for light-sensitive analytes such as nucleic acids, porphyrins, and photosensitive pharmaceuticals. The system complies with FDA 21 CFR Part 11 requirements when operated with Thermo Scientific™ VISIONlite™ Software v3.5+, providing full audit trail, electronic signatures, and role-based user access control. It is validated for GLP/GMP environments and supports IQ/OQ documentation packages aligned with Annex 11 and EU GMP Chapter 4.
Software & Data Management
VISIONlite Software (included) provides method-driven operation with customizable templates for kinetics, scanning, quantitative analysis (single/multi-point calibration), and DNA/RNA/protein quantitation (A260/A280 ratios, extinction coefficients). All raw spectra, processed results, and metadata are stored in vendor-neutral .spc format. Data export supports CSV, PDF (with embedded spectral plots), and XML for seamless integration into ELN platforms (e.g., LabArchives, Benchling). Remote report generation and printing are enabled via secure HTTPS endpoints; instrument status and calibration logs are timestamped and digitally signed to support regulatory traceability.
Applications
- Pharmaceutical QA/QC: Assay validation per USP , excipient interference testing, dissolution profile monitoring
- Academic research: Enzyme kinetics (NADH/NADPH monitoring), ligand-binding studies, nanoparticle size estimation via plasmon resonance
- Environmental testing: Nitrate/nitrite quantification (EPA Method 353.2), COD analysis, heavy metal chelation assays
- Food & beverage: Colorimetric determination of anthocyanins, carotenoids, and Maillard reaction products
- Materials science: Thin-film transmittance/reflectance, bandgap estimation of semiconductors (Tauc plot analysis)
FAQ
Is the GENESYS 180 compliant with 21 CFR Part 11 for electronic records?
Yes—when used with VISIONlite Software v3.5+ and configured with password-protected user roles, full audit trail logging, and digital signature enforcement.
What is the expected lifetime of the xenon lamp under typical usage?
Rated for ≥5 × 10⁹ flashes; equivalent to 5–7 years of routine academic or QC lab operation (assuming ≤200 scans/day).
Can the instrument perform kinetic measurements with time-resolved sampling?
Yes—supports up to 100 points/second acquisition over defined time windows, with trigger synchronization via external TTL input.
Does it support method transfer from older GENESYS models?
All GENESYS 150 methods—including calibration curves, scan parameters, and report formats—are natively compatible and load without conversion.
Is NIST-traceable wavelength verification included in the factory certification?
Yes—each unit ships with a certificate of conformance including holmium oxide filter verification at 241.15, 279.40, 287.50, 333.73, 360.98, 418.50, 460.00, 484.98, 536.23, and 637.50 nm.
