Biotage V-10 Touch High-Speed Vacuum Centrifugal Concentrator
| Brand | Biotage |
|---|---|
| Origin | USA |
| Model | V-10 Touch |
| Instrument Type | Vacuum Centrifugal Concentrator |
| Temperature Range | Ambient to 99 °C |
| Temperature Control Accuracy | ±0.1 °C |
| Sample Capacity | 0–1000 mL |
| Built-in Vacuum Pump | 2 mbar ultimate pressure |
| Maximum Rotor Speed | 8000 rpm |
Overview
The Biotage® V-10 Touch is a high-performance vacuum centrifugal concentrator engineered for rapid, reproducible, and thermally controlled solvent removal from diverse sample matrices—including HPLC fractions, reaction mixtures, and chromatographic eluates. It operates on the principle of simultaneous vacuum-assisted evaporation and centrifugal force-driven sample containment, enabling efficient removal of both low-boiling solvents (e.g., dichloromethane, ethyl acetate) and high-boiling polar aprotic solvents (e.g., DMF, DMSO, NMP) without thermal degradation or bumping. Unlike conventional rotary evaporators or nitrogen blow-down systems, the V-10 Touch integrates real-time infrared-based non-contact temperature monitoring of the rotor chamber, ensuring precise thermal regulation independent of ambient conditions or sample volume. Its architecture supports unattended operation under defined GLP-compliant protocols, making it suitable for regulated environments requiring audit-ready process documentation.
Key Features
- Integrated 2 mbar oil-free vacuum pump delivering consistent low-pressure performance across extended run times
- High-speed rotor system operating up to 8000 rpm with dynamically balanced stainless-steel chambers, minimizing vibration and maximizing solvent removal kinetics
- Patented infrared temperature sensing system—optically coupled to the rotor base—enabling closed-loop thermal control with ±0.1 °C accuracy at the sample interface
- 10.1-inch capacitive touchscreen interface supporting intuitive method programming, real-time parameter adjustment during operation, and multi-language UI localization
- Preloaded method library covering >30 common solvents (including DMSO, DMF, NMP, methanol, acetonitrile), each optimized for evaporation rate, temperature ramp, and vacuum profile
- Modular rotor compatibility accommodating multiple tube formats (1.5–50 mL tubes, microplates, custom glassware) with total capacity ranging from 0 to 1000 mL per run
Sample Compatibility & Compliance
The V-10 Touch accommodates a broad range of sample types encountered in synthetic chemistry, natural product isolation, and pharmaceutical process development—including aqueous buffers, acidic/basic extracts, organometallic solutions, and silica-bound pre-purification mixtures. Its design enables direct drying of wet silica slurries into free-flowing dry powders—a critical capability for flash chromatography sample loading. The instrument complies with IEC 61010-1 for laboratory electrical safety and meets electromagnetic compatibility requirements per EN 61326-1. When operated with validated methods and electronic logbook enabled, it supports 21 CFR Part 11 compliance through user authentication, audit trail generation, and electronic signature functionality—facilitating integration into GxP workflows.
Software & Data Management
The embedded control software provides full method lifecycle management: creation, versioning, locking, and export of SOPs in PDF or CSV format. All operational parameters—including vacuum level, chamber temperature, rotor speed, elapsed time, and error logs—are timestamped and stored locally with optional network backup. Data export supports CSV and XML formats compatible with LIMS and ELN platforms. Remote monitoring via Ethernet or Wi-Fi allows status checks and emergency pause/resume commands from authorized workstations. Optional Biotage Connect software extends functionality with batch scheduling, multi-instrument fleet management, and automated report generation aligned with ISO/IEC 17025 reporting conventions.
Applications
- Rapid concentration of HPLC and preparative LC fractions prior to structural characterization (NMR, MS)
- Post-synthesis workup of high-temperature cross-coupling reactions involving DMF/DMSO solvents
- Preparative-scale sample conditioning for flash chromatography—dry-loading onto silica without caking or channeling
- Stabilization of labile compounds (e.g., peptides, glycosides) via gentle vacuum/centrifugation coupling at sub-boiling temperatures
- Automated parallel processing of compound libraries in medicinal chemistry, integrated with third-party liquid handlers (e.g., Gilson, Tecan)
- Environmental and food testing labs performing QuEChERS extract concentration prior to GC-MS or LC-MS/MS analysis
FAQ
What vacuum level does the built-in pump achieve?
The integrated diaphragm pump delivers an ultimate vacuum of ≤2 mbar, optimized for efficient vapor phase removal across solvent classes.
Can the V-10 Touch handle viscous or foaming samples?
Yes—centrifugal force suppresses foaming, while programmable vacuum ramping and temperature profiling minimize bumping in viscous matrices such as polymer solutions or crude reaction mixtures.
Is rotor calibration required for traceable temperature control?
No—non-contact IR sensing eliminates drift associated with thermocouple-based systems; calibration is factory-performed and verified per ISO/IEC 17025 procedures.
How is data integrity ensured during long unattended runs?
All operational events are logged with cryptographic timestamps; power-loss recovery preserves method state and resumes from last valid checkpoint upon reboot.
Does the system support validation documentation packages?
Biotage provides IQ/OQ documentation templates compliant with ASTM E2500 and EU Annex 11, including test protocols, acceptance criteria, and raw data worksheets for installation and operational qualification.
