CoMetro CP100-LDI Parallel Dual-Head High-Pressure Precision Isocratic Pump
| Brand | CoMetro |
|---|---|
| Model | CP100-LDI |
| Pump Type | Isocratic Binary-Compatible Dual-Head HPLC Pump |
| Max Pressure | 6000 psi |
| Flow Rate Range | 0.001–12 mL/min |
| Flow Accuracy | ±1% |
| Flow Precision | ≤0.1% RSD |
| Pump Head Configuration | Parallel Dual Plunger Heads |
| Pressure Units | psi / MPa / bar |
| Control Modes | Front-panel Keypad, RS-232/USB PC Interface, Analog Input (0–5 V or 4–20 mA) |
| Compressibility Compensation | Adjustable |
| Solvent Degassing & Purge | Integrated Low/High-Pressure Flush Function |
| Auto-Cleaning Mode | Available for Salt-Containing Mobile Phases |
| Compliance | Designed for GLP/GMP environments |
Overview
The CoMetro CP100-LDI is a high-performance, parallel dual-head isocratic pump engineered for demanding liquid chromatography applications—including analytical HPLC, semi-preparative purification, and scalable method development workflows. Unlike conventional single-piston systems, the CP100-LDI employs two synchronized, independently actuated plunger heads operating in parallel configuration. This architecture eliminates pulsation-induced baseline noise and delivers exceptional flow stability across the full operational range (0.001–12 mL/min), even at maximum pressure (6000 psi). The pump operates on positive displacement principle with ceramic-coated plungers and sapphire-hardened check valves, ensuring long-term mechanical integrity and chemical resistance to aggressive solvents and aqueous buffers. Its modular design supports seamless integration into existing LC systems or as a standalone gradient-ready platform when paired with optional solvent selection valves and mixing modules.
Key Features
- Parallel dual-plunger head architecture enabling ultra-low pulsation (<0.1% RSD) and continuous flow delivery without dwell volume penalties
- Real-time pressure monitoring with user-definable upper/lower limits and automatic shutdown protection at 6000 psi maximum rating
- Compressibility compensation algorithm dynamically adjusts stroke volume based on solvent composition and system backpressure
- Front-panel keypad with high-brightness LED display for remote readability—supports simultaneous flow rate (mL/min), pressure (psi/MPa/bar), and status indicators
- Multi-mode control interface: local keypad operation, RS-232/USB-connected PC software, or analog external triggering (0–5 V DC or 4–20 mA)
- Dedicated low-pressure purge and high-pressure flush functions for rapid system equilibration and bubble removal
- Programmable auto-cleaning cycle specifically optimized for phosphate- or acetate-based mobile phases to extend seal and piston rod service life
Sample Compatibility & Compliance
The CP100-LDI accommodates a broad spectrum of mobile phase chemistries, including water/acetonitrile, methanol/water, THF, chloroform, and acidic or basic aqueous buffers (pH 1.5–12.0) when used with compatible wetted materials (316L stainless steel, PEEK, sapphire, ruby). All fluidic pathways comply with USP Class VI biocompatibility standards. The pump’s firmware architecture supports time-stamped event logging and user-access-level authentication—critical for laboratories operating under ISO/IEC 17025, ASTM D3618, or ICH Q2(R2) validation frameworks. When integrated with compliant chromatography data systems (CDS), it meets FDA 21 CFR Part 11 requirements for electronic records and signatures, including audit trail generation and operator action traceability.
Software & Data Management
The CP100-LDI communicates via standard ASCII protocol over RS-232 or USB virtual COM port, enabling native compatibility with third-party CDS platforms (e.g., Chromeleon, Empower, OpenLab). Optional CoMetro PumpControl Suite provides method-driven automation: scheduled flow/pressure ramps, sequence-triggered purge cycles, and real-time deviation alerts. All parameter changes are timestamped and logged with operator ID. Data export supports CSV and XML formats for LIMS integration. Remote diagnostics and firmware updates are performed securely over authenticated connections, preserving system integrity during maintenance intervals.
Applications
- Analytical-scale reversed-phase HPLC for pharmaceutical impurity profiling and stability-indicating assays
- Semi-preparative purification of peptides, natural products, and synthetic intermediates under controlled pressure and flow conditions
- Method transfer between analytical and preparative platforms due to consistent hydraulic performance across flow ranges
- Isocratic method development for ion chromatography and size-exclusion chromatography where pulse-free elution is critical
- Integration into custom-built SFC or UHPLC systems requiring robust, field-serviceable pumping solutions
FAQ
Can the CP100-LDI be used in gradient mode?
Yes—when combined with an external low-dead-volume proportioning valve or a dedicated gradient mixer module, the CP100-LDI serves as a stable dual-channel isocratic source for binary or ternary gradient formation.
What maintenance intervals are recommended for the pump heads?
Under typical usage with organic/aqueous solvents, seal replacement is advised every 6–12 months; piston rods require inspection every 3 months in high-salt applications. Auto-cleaning cycles reduce frequency by up to 40%.
Is remote firmware update supported?
Yes—secure over-the-air updates are available through authenticated USB or network connection using CoMetro’s certified firmware signing protocol.
Does the pump support GLP-compliant electronic signatures?
When operated within a validated CDS environment supporting 21 CFR Part 11, all parameter changes, method executions, and error logs retain digital signature linkage and immutable timestamps.
Can multiple CP100-LDI units be synchronized?
Up to four units can be daisy-chained via TTL trigger signals for coordinated start/stop and flow ramping—enabling multi-dimensional separation schemes or parallel column screening.
