Sartorius Cubis® II MPS116S-CCN Single-Channel Pipette Calibration System
| Brand | Sartorius |
|---|---|
| Origin | Germany |
| Model | MPS116S-CCN |
| Compliance | ISO 8655, JJG 646 |
| Calibration Range (ISO 8655) | 2 µL – 5 mL |
| Calibration Range (JJG 646) | 0.1 µL – 10 mL |
| Integrated Environmental Monitoring | Temperature, Humidity, Air Pressure |
| Software Compatibility | QApp, Ingenix Suite |
| Data Traceability | Full audit trail, GLP/GMP-ready logging |
| Ergonomic Design | Motorized lid, integrated desiccant chamber, low-effort operation |
Overview
The Sartorius Cubis® II MPS116S-CCN is a fully integrated, high-precision single-channel pipette calibration system engineered for metrological traceability and operational efficiency in regulated laboratory environments. Based on the gravimetric principle—where liquid mass is measured via high-resolution analytical balance technology under controlled environmental conditions—the system delivers direct, SI-traceable volume determinations in accordance with ISO 8655 (Pipettes — Gravimetric methods for calibration) and JJG 646–2015 (Verification Regulation for Pipettes, People’s Republic of China). Unlike legacy multi-instrument setups requiring separate balances, environmental chambers, and manual data transcription, the MPS116S-CCN consolidates all core calibration functions into a single, self-contained platform. Its modular architecture integrates a Class I ultra-micro balance (0.001 mg readability), active environmental monitoring (real-time water temperature, ambient humidity, and barometric pressure), and automated evaporation compensation algorithms—enabling repeatable, uncertainty-optimized measurements across the full calibrated range.
Key Features
- Single-platform calibration covering >95% of routine single-channel pipettes—from 0.1 µL (per JJG 646) to 10 mL—with no hardware reconfiguration required.
- Integrated environmental sensor suite continuously monitors and logs water temperature (±0.1 °C), relative humidity (±1 %RH), and atmospheric pressure (±0.1 hPa), enabling real-time correction of air buoyancy and thermal expansion effects per ISO 8655 Annex B.
- Motorized, auto-sealing lid minimizes evaporation loss during weighing cycles; integrated desiccant chamber maintains stable vapor-phase conditions above the weighing pan, critical for low-volume (<10 µL) calibrations.
- Ergonomically optimized work surface height, adjustable tilt angle, and low-force pipette placement mechanism reduce operator fatigue during high-throughput calibration workflows.
- Pre-validated firmware with built-in uncertainty calculation engine compliant with EURAMET cg-18 and GUM (JCGM 100:2008) guidelines—outputting expanded uncertainty (k=2) for each calibration point.
Sample Compatibility & Compliance
The MPS116S-CCN supports all standard conical-tip, fixed- and variable-volume single-channel pipettes meeting ISO 8655 mechanical specifications—including those with polymer, stainless-steel, or hybrid tip cones. It accommodates both forward and reverse pipetting techniques and is validated for use with deionized water (conductivity <1 µS/cm), certified reference standards traceable to NIST SRM 3197, and ISO 4787-compliant volumetric glassware. Regulatory alignment includes full support for 21 CFR Part 11 (electronic records/signatures), ALCOA+ data integrity principles, and GLP/GMP audit readiness—via time-stamped, user-authenticated, immutable calibration reports generated directly from the instrument’s embedded database.
Software & Data Management
Calibration workflows are managed through two interoperable software layers: QApp—a tablet-based, guided interface for technician-level operation—and Ingenix Suite, a desktop application for method development, multi-instrument fleet management, and regulatory reporting. Both platforms enforce role-based access control (RBAC), automatic version-controlled method storage, and full electronic audit trails compliant with FDA 21 CFR Part 11 Annex 11 and EU GMP Annex 11. All raw mass data, environmental metadata, and calculated volume deviations are stored in encrypted SQLite databases with SHA-256 hashing; export formats include PDF/A-2b (archival), CSV (statistical analysis), and XML (LIMS integration).
Applications
This system is deployed in quality control laboratories of pharmaceutical manufacturers (supporting USP , ICH Q5E), clinical diagnostic facilities (CLIA, CAP), contract research organizations (CROs), and national metrology institutes performing primary verification of pipette performance. Typical use cases include periodic verification of pipettes used in qPCR assay setup, cell culture media dispensing, ELISA plate preparation, and reference standard dilution—where volumetric accuracy directly impacts assay sensitivity, precision, and regulatory filing validity. Its portability and rapid commissioning (<60 minutes post-installation) also make it suitable for field service calibration teams supporting decentralized lab networks.
FAQ
Does the MPS116S-CCN require external calibration of its internal balance?
No—the integrated analytical balance is factory-calibrated with traceable weights and includes automated internal recalibration routines triggered by temperature drift or time-based schedules.
Can the system generate certificates compliant with ISO/IEC 17025?
Yes—when operated under an accredited quality management system, it produces calibration certificates containing all mandatory elements per ISO/IEC 17025:2017 Clause 7.8, including measurement uncertainty budgets and traceability statements.
Is remote monitoring or troubleshooting supported?
Yes—via optional Ethernet/Wi-Fi connectivity and secure TLS 1.2–encrypted remote desktop access for Sartorius Field Service Engineers, subject to customer network policy approval.
What maintenance intervals are recommended?
Annual performance verification using Sartorius-certified reference standards is advised; desiccant cartridge replacement every 6 months; and routine cleaning of the weighing chamber per SOP-MS-027 (provided in the installation qualification package).
