Shanghai Youyi LHS-150CB Low-Temperature Temperature and Humidity Controlled Chamber

Overview

The Shanghai Youyi LHS-150CB is an upright, air-cooled temperature and humidity controlled chamber engineered for precise, long-term environmental simulation in research and quality assurance laboratories. It operates on the principle of closed-loop microprocessor-controlled thermodynamic regulation—integrating independent refrigeration, resistive heating, and vapor-phase humidification subsystems—to maintain stable thermal and hygric conditions across its 150 L working volume. Designed for applications requiring strict adherence to ISO 17025, ICH Q5C, and USP environmental stability protocols, the LHS-150CB supports critical storage and testing of biologics (e.g., plasma, vaccines, cell cultures), electronic components, polymer specimens, and pharmaceutical intermediates under reproducible climatic stress conditions.

Key Features

• Microcomputer-based PID dual-loop control system with 5.7-inch backlit LCD interface; supports up to 99 programmable cycles, each comprising 30 configurable segments (max. 99 h 59 min per segment) for complex ramp-soak-hold profiles.
• Double-glazed insulated door with silicone-sealed glass viewport minimizes thermal leakage while enabling real-time visual monitoring without chamber disturbance.
• High-efficiency air-circulation duct design ensures uniform temperature distribution (±0.5 °C) and humidity homogeneity (±3% RH) throughout the working chamber, validated per ASTM E2867–22 Annex A1.
• Interior constructed from electropolished mirror-finish stainless steel (AISI 304), featuring radius-rounded corners and adjustable shelf rails for GMP-compliant cleaning and flexible load configuration.
• Eco-friendly refrigerant R134a/R406a system compliant with EU F-Gas Regulation (EU) No. 517/2014; optimized for low power consumption (4000 W nominal input) and reduced global warming potential (GWP).
• Integrated humidity generation via stainless-steel sheathed heating element immersed in a self-contained water reservoir; paired with a calibrated capacitive humidity sensor (Vaisala HUMICAP® or equivalent) for traceable RH accuracy.
• Mobile base with four swivel casters (two with mechanical locking brakes) and adjustable leveling feet enables safe repositioning in shared lab spaces without compromising structural stability.

Sample Compatibility & Compliance

The LHS-150CB accommodates diverse sample formats—including stacked vial racks, multi-well plates, sealed petri dishes, PCB trays, and bulk material containers—within its 480 × 390 × 780 mm chamber. Its temperature range (−20 °C to +80 °C) and humidity span (30–95% RH) align with ICH Q1A(R2) long-term and accelerated stability testing guidelines. The chamber meets essential safety and electromagnetic compatibility requirements per GB/T 14710–2009 (Chinese national standard for environmental test equipment) and is compatible with GLP/GMP documentation workflows when integrated with optional data logging modules. Optional accessories—including RS485/USB interfaces, embedded thermal printers, and external port kits (25 mm/50 mm)—support audit-ready data capture per FDA 21 CFR Part 11 requirements when used with validated software.

Software & Data Management

While the standard controller provides local program execution and real-time parameter display, optional communication interfaces enable integration into centralized laboratory information management systems (LIMS). The USB/RS485 module permits time-stamped export of temperature/humidity logs (CSV format) and remote firmware updates. When paired with Shanghai Youyi’s proprietary data acquisition software (sold separately), users gain access to automated report generation, alarm history tracking, deviation alerts, and electronic signature support—facilitating compliance with ALCOA+ data integrity principles. All logged data retains full traceability, including operator ID, timestamp, setpoint, actual reading, and system status flags.

Applications

• Stability studies of pharmaceutical products and biologics per ICH Q5C and WHO TRS 1010 Annex 9.
• Clinical sample preservation (serum, PBMCs, cryopreserved tissues) at defined sub-zero or ambient-humid conditions.
• Accelerated aging tests for polymers, adhesives, and packaging materials per ASTM D3045 and ISO 4892-2.
• Environmental stress screening of printed circuit boards (PCBs) and semiconductor assemblies prior to qualification testing.
• Calibration verification of hygrometers and thermometers under controlled reference conditions.
• Material conditioning for tensile, impact, or dielectric property measurements per ISO 291 and ASTM D618.

FAQ

What is the maximum allowable ambient operating temperature for the LHS-150CB?

The unit is rated for installation in environments ≤30 °C and ≤70% RH (non-condensing), as specified in GB/T 14710–2009.
Does the chamber support validation protocols such as IQ/OQ/PQ?

Yes—the LHS-150CB’s mechanical and control architecture supports third-party qualification; documentation templates and sensor calibration certificates are available upon request.
Can the internal shelves be removed for large-format sample loading?

All three standard shelves are fully removable and repositionable on vertical guide rails, allowing unobstructed access to the full chamber volume.
Is remote monitoring possible without purchasing additional hardware?

No—remote data access requires the optional RS485 or USB interface module and compatible host software.
What maintenance intervals are recommended for optimal performance?

Compressor oil and refrigerant pressure checks every 24 months; condenser coil cleaning every 6 months; humidity sensor recalibration annually or after 2000 operational hours.