RAININ NanoRep Electric Continuous Dispenser

Overview

The RAININ NanoRep Electric Continuous Dispenser is a precision-engineered, handheld positive displacement instrument designed for high-accuracy, low-volume continuous dispensing in regulated and research-intensive laboratory environments. Unlike air-cushion pipettes, the NanoRep employs an external piston mechanism—physically coupled to the disposable dispensing tip—to eliminate compressible air gaps and ensure volumetric fidelity across viscous, volatile, dense, or temperature-sensitive liquids. Its operational principle relies on controlled linear actuation of the piston within the tip, enabling true volumetric delivery independent of ambient humidity, temperature fluctuations, or liquid vapor pressure. With a total dispense range spanning 100 nanoliters to 50 milliliters—and programmable step increments as fine as 0.01% of the selected tip’s nominal capacity—the NanoRep bridges the gap between microfluidic precision and bulk transfer efficiency. It is engineered for applications requiring strict adherence to ISO 8655 calibration standards and supports traceable, audit-ready operation in quality control, assay development, and bioprocess analytics.

Key Features

• External piston architecture for direct mechanical displacement—ideal for glycerol, DMSO, ethanol, cell lysates, and high-salt buffers
• Three interchangeable dispensing tips (100 nL–10 µL, 1–100 µL, and 10–50,000 µL), each optimized for its designated range and certified per ISO 8655 Annex B
• Motor-driven dispensing with adjustable interval timing (minimum 0.5 s between dispenses) and programmable cycle count (up to 1,000 dispenses per aspiration)
• Touch-free dispensing mode enabled via proximity sensor—reducing aerosol generation and cross-contamination risk in sterile or high-throughput workflows
• Onboard memory for up to 10 user-defined protocols, including volume, step size, number of cycles, and pause intervals
• Ergonomic, balanced housing with integrated wall-mount charger and hook-based storage—designed for extended daily use without operator fatigue

Sample Compatibility & Compliance

The NanoRep demonstrates consistent performance across a broad physicochemical spectrum: aqueous solutions, organic solvents, surfactant-containing buffers, protein-rich media, and suspensions up to 10⁶ cP viscosity. Its positive displacement system eliminates reliance on air compression, making it inherently suitable for low-volatility and high-density liquids where traditional air-displacement pipettes exhibit drift or under-delivery. All dispensing tips are manufactured to ISO 8655-3 tolerances and individually calibrated; certificates of conformance accompany each tip batch. The device meets IEC 61326-1 (EMC) and IEC 61010-1 (safety) requirements. When used with validated software and electronic logbooks, the NanoRep supports compliance with FDA 21 CFR Part 11, EU Annex 11, and GLP/GMP data integrity principles—including electronic signatures, audit trails, and protocol version control.

Software & Data Management

While the NanoRep operates independently via intuitive rotary dial and OLED interface, optional integration with METTLER TOLEDO LabX® software enables centralized method management, real-time usage tracking, and automated report generation. LabX captures timestamped dispense events—including tip ID, volume setpoint, actual dispense count, and operator ID—into a secure, searchable database. All data entries are immutable and include digital signatures compliant with ALCOA+ principles (Attributable, Legible, Contemporaneous, Original, Accurate, Complete, Consistent, Enduring, Available). Audit trail functionality records every parameter change, user login/logout, and firmware update—ensuring full traceability during internal audits or regulatory inspections.

Applications

• High-throughput screening (HTS) plate filling with sub-microliter accuracy for enzymatic assays and receptor binding studies
• Serial dilution preparation in qPCR, ELISA, and NGS library quantification workflows
• Cell culture reagent dispensing—especially for serum-free or phenol red–free media sensitive to aerosol contamination
• Calibration standard preparation in reference laboratories requiring <±0.6% CV at 1 µL (per ISO 8655-6)
• QC release testing of injectables and ophthalmic solutions where endotoxin carryover must be minimized
• Microbiological inoculation of agar plates or broth cultures using contactless dispensing to preserve sterility

FAQ

What types of liquids can the NanoRep accurately dispense?
It is validated for aqueous buffers, alcohols, glycerol (up to 85% v/v), DMSO, acetonitrile, and biological samples such as whole blood, plasma, and cell suspensions—with no pre-wetting or priming required.
Is calibration required before first use?
Yes. Each dispensing tip must be calibrated using RAININ-certified gravimetric procedures per ISO 8655-6. Factory calibration certificates are provided; field recalibration is recommended every 3–6 months depending on usage frequency and criticality.
Can the NanoRep be connected to LIMS or ERP systems?
Via LabX middleware, it supports direct export of structured JSON or CSV logs compatible with major LIMS platforms (e.g., Thermo Fisher SampleManager, LabWare LIMS) and enterprise data warehouses.
Does it support multi-user authentication?
When paired with LabX, role-based access control (RBAC) allows assignment of permissions by function—e.g., operators may run protocols, while supervisors can modify methods and approve calibration records.
How is maintenance performed?
The external piston assembly requires only periodic cleaning with isopropanol and lint-free wipes; no lubrication or internal servicing is needed. Tip ejector mechanisms are wear-tested to >100,000 cycles and covered under RAININ’s 2-year limited warranty.