ACQ-06 Multifunctional Column Switcher for HPLC and Prep Chromatography Systems
| Origin | Tianjin, China |
|---|---|
| Manufacturer Type | Authorized Distributor |
| Product Origin | Domestic (China) |
| Model | ACQ-06 |
| Pricing | Available Upon Request |
| Instrument Type | Liquid Chromatography Column Switching Module |
| Fluidic Path Materials | SS316L, PTFE, ETFE, PEEK |
Overview
The ACQ-06 Multifunctional Column Switcher is an engineered solution for automated column selection and flow path reconfiguration in liquid chromatography workflows. Designed to operate either as a dedicated module integrated with BonAjet CHEETAH-series preparative purification systems or as a standalone switching interface compatible with third-party HPLC, UHPLC, and preparative LC platforms, the ACQ-06 eliminates manual column swapping—reducing operator intervention, minimizing system downtime, and enhancing method reproducibility. Its operation relies on precision-machined multi-port valve actuation synchronized with instrument control signals, enabling programmable, time- or event-triggered column routing without flow interruption or pressure spikes. The device supports both high-pressure and low-pressure switching configurations, making it suitable for applications ranging from analytical-scale method development to gram-scale purification.
Key Features
- Modular integration architecture supporting both OEM coupling (via TTL/RS-232/USB command protocols) and independent operation via front-panel keypad or external trigger inputs
- High-integrity fluidic path constructed entirely from chemically inert, low-extractable materials: electropolished SS316L for structural integrity, PTFE and ETFE for tubing and sealing components, and PEEK for high-pressure fittings and rotor seals
- Pressure rating up to 400 bar (5800 psi) at ambient temperature, validated for continuous use with common LC solvents including acetonitrile, methanol, water, and acidic/basic mobile phases
- Low dead volume design (< 12 µL per port transition) to preserve chromatographic resolution and minimize carryover between column selections
- Configurable valve positions (6-port standard; optional 10-port configuration available upon request) supporting serial, parallel, or bypass flow routing topologies
- Onboard non-volatile memory retains user-defined switching sequences and calibration offsets, ensuring consistent behavior after power cycling
Sample Compatibility & Compliance
The ACQ-06 is compatible with reversed-phase, normal-phase, ion-exchange, size-exclusion, and chiral chromatography columns across standard dimensions (1.0–50 mm ID, 10–250 mm length). It complies with ISO 9001-certified manufacturing practices and meets mechanical safety requirements outlined in IEC 61010-1 for laboratory equipment. While not classified as a medical device, its material composition adheres to USP Class VI biocompatibility standards for wetted components. When deployed in regulated environments (e.g., pharmaceutical QC labs), the ACQ-06 supports audit-ready operation when paired with chromatography data systems (CDS) that provide electronic records, user access controls, and 21 CFR Part 11-compliant audit trails.
Software & Data Management
The ACQ-06 operates natively with BonAjet’s CHEETAH Control Software v4.2+, enabling full synchronization of column switching events with gradient programming, fraction collection, and UV detection triggers. For integration with third-party CDS platforms—including Thermo Chromeleon, Waters Empower, Agilent OpenLab, and Shimadzu LabSolutions—the device accepts ASCII-based serial commands and provides real-time status feedback (valve position, error codes, cycle count). All switching events are timestamped and logged internally; logs can be exported via USB mass storage mode for GLP/GMP documentation. Firmware updates are performed through secure signed binaries to ensure traceability and prevent unauthorized modification.
Applications
- Automated multi-column method scouting for HPLC method development
- Heart-cutting and comprehensive 2D-LC (LC×LC) configurations requiring precise retention-time-aligned column transfers
- Online sample cleanup using guard column or trapping column switching prior to analytical separation
- Parallel purification workflows where multiple columns undergo simultaneous equilibration and sequential elution
- Method transfer between analytical and preparative systems using identical column chemistries and switching logic
- Automated stability-indicating assays involving pH- or solvent-switched column sets for forced degradation analysis
FAQ
Can the ACQ-06 be used with UHPLC systems operating above 600 bar?
No—the ACQ-06 is rated for maximum continuous pressure of 400 bar; for ultra-high-pressure applications, consult the manufacturer for custom valve assemblies.
Does the ACQ-06 support gradient-compatible switching without baseline disturbance?
Yes—its low-dead-volume rotor seal design and pre-synchronized actuation timing ensure minimal pressure fluctuation and no observable baseline drift during active gradient runs.
Is validation documentation (IQ/OQ/PQ protocols) available?
Yes—standardized qualification templates aligned with ASTM E2500 and EU Annex 15 are provided upon request for regulated lab deployment.
How is leak detection handled during extended unattended operation?
The ACQ-06 includes integrated pressure monitoring at inlet and outlet manifolds; sustained deviation beyond ±5% of setpoint triggers automatic valve shutdown and system alert via digital output.
Can switching sequences be programmed based on detector signal thresholds?
Yes—when interfaced with compatible CDS software, column transitions can be triggered by real-time UV absorbance, conductivity, or mass spectrometer peak intensity thresholds.
