Aerosol Generator System for Inhalation Toxicology Studies
| Origin | USA |
|---|---|
| Manufacturer Type | Authorized Distributor |
| Origin Category | Imported Instrument |
| Model | AG-2000 Series Aerosol Generator |
| Pricing | Available Upon Request |
Overview
The AG-2000 Series Aerosol Generator System is a precision-engineered platform designed for controlled, reproducible generation of test atmospheres in inhalation toxicology, pharmacokinetic, and respiratory drug delivery research. It operates on the principle of pneumatic nebulization combined with thermally regulated vaporization, enabling simultaneous or sequential delivery of liquid aerosols, solid particulates (e.g., dry powders, micronized APIs), and condensable vapors within a calibrated exposure chamber environment. The system is engineered to meet the stringent operational requirements of OECD TG 412, ASTM E1789-22, and ISO 10993-12 for whole-body or nose-only rodent exposure studies. Its modular architecture supports GLP-compliant study execution when integrated with validated environmental monitoring and dosimetry control modules.
Key Features
- Modular dual-nozzle configuration: Accepts two independently controllable aerosol nozzles—compatible with Collison, Babcock, or custom-designed jet nozzles—for co-generation of dissimilar aerosol types (e.g., saline droplets + TiO₂ nanoparticles) without cross-contamination.
- Multi-phase generation capability: Integrates three parallel generation pathways—liquid nebulization (0.5–20 µm MMAD), dry powder dispersion (1–100 µm aerodynamic diameter), and thermal vaporization (for volatile organics, propellants, or solvent-based formulations).
- Automated aerosol initiation and termination: Programmable start/stop sequences synchronized with chamber airflow (0.1–20 L/min), ensuring precise temporal control over exposure duration and duty cycle.
- Real-time mass concentration monitoring interface: Equipped with analog/digital outputs compatible with TSI CPC 3776, Grimm 1.108, or MetOne BAM-1020 for closed-loop feedback control.
- Stainless-steel fluid path with heated lines (up to 120°C): Prevents condensation and particle agglomeration during vapor-phase operation; all wetted components comply with USP Class VI biocompatibility standards.
Sample Compatibility & Compliance
The AG-2000 accommodates a broad range of test agents—including aqueous suspensions, organic solvents (e.g., ethanol, DMSO), liposomal formulations, polymer microparticles, and volatile compounds such as diacetyl or formaldehyde. All aerosol output profiles are characterized per ISO 27427:2012 for respirable fraction validation. The system meets mechanical safety requirements per IEC 61000-6-2/6-4 and carries CE marking under the EU Machinery Directive 2006/42/EC. When deployed in GMP-regulated preclinical labs, it supports 21 CFR Part 11-compliant audit trails via optional data logging firmware (AG-LOG v3.1).
Software & Data Management
Control is executed via AG-Control Suite v4.2—a Windows-based application supporting protocol-driven method templates, multi-step exposure ramps, and real-time parameter visualization (aerosol flow rate, pressure differential, temperature setpoints). Raw sensor data (mass concentration, humidity, temperature) are timestamped and exported in CSV or HDF5 format. The software includes built-in calibration wizards aligned with NIST-traceable reference standards and generates IQ/OQ documentation packages for regulatory submissions. Audit trail functionality records user login events, parameter changes, and method execution logs with immutable timestamps.
Applications
- Regulatory inhalation toxicity testing (OECD 412, 413, 436) in rats and mice using whole-body or head-only exposure chambers.
- In vitro air-liquid interface (ALI) culture exposure for pulmonary epithelial barrier integrity and cytokine profiling.
- Development and dose-ranging studies of inhaled therapeutics—including corticosteroids, bronchodilators, and mRNA-LNPs.
- Environmental health research on nanoparticle translocation, diesel exhaust particulate (DEP), or wildfire smoke surrogates.
- Respiratory protection evaluation—filter penetration testing and facepiece fit assessment under dynamic aerosol challenge conditions.
FAQ
What aerosol size distributions can the AG-2000 achieve?
The system delivers mass median aerodynamic diameters (MMAD) from 0.3 µm (via Collison nebulizer) to 15 µm (via rotary atomizer), with geometric standard deviations (GSD) between 1.4–2.2 depending on nozzle selection and carrier gas parameters.
Is the system compatible with nose-only exposure chambers?
Yes—its compact footprint and low-vibration design allow direct integration with standard 12-port or 24-port nose-only systems (e.g., CH Technologies or Promech models) via 1/2″ Swagelok fittings.
Can vapor and particulate generation occur simultaneously?
Yes—dual independent generation channels enable concurrent operation, provided vapor condensation temperatures remain above dew point thresholds in the mixing manifold.
Does the AG-2000 support automated daily calibration verification?
With optional AG-CalCheck module, users can perform semi-automated flow and pressure verification using certified reference orifices traceable to NIST SRM 2806.
What maintenance intervals are recommended for routine operation?
Nozzle cleaning every 10 hours of cumulative use; vaporization cartridge replacement every 200 hours; full system leak check and flow calibration every 90 days per SOP-AG-MNT-01.
