BenAng UP-15UVF Integrated Ultra-Pure Water System

Overview

The BenAng UP-15UVF Integrated Ultra-Pure Water System is a fully automated, multi-stage laboratory water purification platform engineered to convert municipal tap water into Type I ultrapure water meeting stringent international standards for critical analytical and life science applications. Utilizing a validated sequence of pretreatment, reverse osmosis (RO), dual-wavelength ultraviolet photo-oxidation (254 nm germicidal + 185 nm TOC abatement), mixed-bed deionization, ultrafiltration (5 kDa MWCO), and final 0.22 µm membrane filtration, the system delivers consistent water quality with resistivity up to 18.2 MΩ·cm at 25 °C, total organic carbon (TOC) <5 ppb, endotoxin <0.001 EU/mL, and microbial load 99% salt rejection, >99.5% bacterial removal), dual-stage UV irradiation, and recirculating loop design to maintain continuous on-demand purity—eliminating stagnation-related contamination risks common in static storage systems.

Key Features

• Fully automated operation with intelligent pressure-sensing control: automatic RO membrane anti-scaling flush, dry-run protection, reservoir auto-fill, full-tank shutdown, and mains interruption response
• Dual-wavelength UV system (254 nm + 185 nm) for simultaneous microbial inactivation and photochemical TOC oxidation
• High-efficiency 5 kDa molecular weight cutoff (MWCO) ultrafiltration module certified for endotoxin removal (retention >99.99%)
• Final 0.22 µm sterilizing-grade terminal filter from Sartorius (Germany), compliant with ISO 8573-7 and USP
• Backlit LCD conductivity/resistivity monitor with real-time online measurement and data logging capability
• Modular, service-friendly design with standardized consumables—pre-filters rated for 24-month service life under typical municipal feed conditions
• Integrated dual-loop configuration: primary RO loop + secondary UP recirculation loop with continuous polishing to sustain peak resistivity

Sample Compatibility & Compliance

The UP-15UVF is validated for use with feed water conforming to municipal drinking water specifications (TDS ≤200 ppm, temperature 5–40 °C, inlet pressure 1.0–3.5 kg/cm²). It produces water compliant with ASTM D1193 Type I, CLSI EP21-A (formerly NCCLS), GB/T 6682–2008 Grade I (Chinese National Standard for Analytical Laboratory Water), and GB/T 11446.1–1997 EL-1 (Electronic Grade Ultrapure Water). All wetted components—including RO membranes (Dow Filmtec™), UV quartz sleeves (Pall), ultrafiltration cartridges (Pall), and final filters (Sartorius)—are constructed from USP Class VI-certified materials. The system supports GLP/GMP-aligned operation through configurable audit trail logging (via optional RS232/USB interface) and meets foundational requirements for FDA 21 CFR Part 11 readiness when paired with validated LIMS integration.

Software & Data Management

While the UP-15UVF operates as a standalone instrument without embedded PC-based software, its digital display provides timestamped resistivity/temperature readings and system status flags (e.g., “RO Flush Active”, “UF Cartridge Life <10%”). Optional analog output (4–20 mA) and digital communication interfaces (RS232 or USB) enable integration into centralized facility monitoring systems or laboratory information management systems (LIMS). All operational events—including automatic flush cycles, low-pressure alarms, and reservoir fill/empty transitions—are logged internally with date/time stamps. For regulated environments, raw data export (CSV format) and electronic signature-compatible reporting modules are available via BenAng’s certified firmware upgrade package (v3.2+), supporting traceability per ISO/IEC 17025 and GxP documentation requirements.

Applications

This system serves as a primary water source for high-sensitivity analytical instrumentation requiring particulate-free, low-ionic, low-organic, and pyrogen-free water. Key applications include: HPLC and UHPLC mobile phase preparation; ICP-MS and ICP-OES sample dilution and blanking; atomic absorption spectroscopy (AAS); cell culture media formulation and sterile filtration; recombinant protein purification (e.g., affinity chromatography buffers); qPCR and NGS reagent preparation; semiconductor wafer rinsing (per SEMI F57); and calibration standard preparation for clinical chemistry analyzers. Its dual-outlet configuration allows simultaneous supply of RO water (for glassware rinsing, buffer stock preparation) and ultrapure water (for final dilutions, critical assays), optimizing workflow efficiency without cross-contamination risk.

FAQ

What is the expected service life of the RO membrane under typical municipal feed water conditions?
With proper pretreatment and automatic anti-scaling flush cycles, the Dow Filmtec™ RO membrane typically achieves 24–36 months of service life when inlet TDS remains below 200 ppm and feed water is chlorinated per municipal standards.
Does the system support remote monitoring or network connectivity?
Standard configuration includes RS232 and USB ports for local data capture; Ethernet or Wi-Fi connectivity requires optional hardware add-on (UP-15UVF-NET v2.0) and compatible facility SCADA integration.
Is the UP-15UVF compliant with ISO 13485 or FDA 21 CFR Part 11 out-of-the-box?
The base unit meets material and performance prerequisites; full Part 11 compliance requires installation of validated electronic log software, user access controls, and audit trail configuration—available through BenAng’s GxP Support Package.
Can the system be connected to an external storage tank?
Yes—the UP-15UVF features programmable reservoir interface logic and supports connection to external stainless-steel or PE tanks (up to 100 L) with level-sensor feedback for seamless fill-and-hold operation.
How often must the 0.22 µm terminal filter be replaced?
Under continuous use at 15 L/h and confirmed upstream integrity, the Sartorius Steritop® filter is rated for 1,500–2,000 liters of ultrapure water output or 6 months—whichever occurs first—and triggers a visual alert upon saturation.