Chengmeng CM-12 Water Bath Nitrogen Evaporator

Overview

The Chengmeng CM-12 Water Bath Nitrogen Evaporator is an engineered solution for gentle, reproducible solvent removal in analytical laboratories. It operates on the principle of controlled nitrogen gas displacement over heated liquid surfaces—leveraging convective heat transfer and inert gas sparging to accelerate evaporation without thermal degradation. Unlike dry-block or air-blow systems, the water bath design ensures uniform thermal distribution across all 12 sample positions, minimizing inter-sample variability and supporting quantitative recovery of thermolabile analytes. The instrument is purpose-built for routine concentration tasks in regulated environments where trace-level analyte integrity, method robustness, and operator safety are critical—particularly in pesticide residue analysis, pharmaceutical QC, environmental monitoring, and clinical bioanalysis.

Key Features

• 12-position stainless steel sample rack with spring-loaded, numbered tube clamps—compatible with tubes (Ø10–29 mm), centrifuge tubes, conical vials, and small-volume flasks (1–50 mL capacity)
• Adjustable-height stainless steel gas needles (150 mm standard length) with independent needle-valve controls per position—enabling precise, user-defined nitrogen flow regulation (0–15 L/min total; ~330 mL/min per channel at full setting)
• Digital PID temperature controller with 0.1°C display resolution, ±0.5°C accuracy, and ±0.5°C uniformity at 60°C—supports programmable ramping, hold functions, and auto-shutdown on overtemperature or dry-bath detection
• Corrosion-resistant, solvent-compatible construction: 316 stainless steel bath vessel, food-grade silicone tubing (imported from Japan), and chemically inert internal components
• Rotatable circular water bath platform for ergonomic access—facilitates rapid loading/unloading while maintaining consistent immersion depth and thermal contact
• Dual-gas inlet capability (N₂ and compressed air) with dedicated pressure regulators—enables method flexibility: nitrogen for oxygen-sensitive samples (e.g., lipid peroxides, catecholamines), ambient air for stable matrices (e.g., pesticide standards in acetonitrile)
• Integrated timer (0–9999 minutes) with audible end-of-cycle alert and non-volatile memory retention

Sample Compatibility & Compliance

The CM-12 accommodates a broad range of container geometries and solvent systems, including aqueous, methanolic, ethyl acetate, dichloromethane, and hexane-based extracts. Its design conforms to fundamental requirements of ISO/IEC 17025:2017 for equipment qualification—supporting documented calibration of temperature and flow parameters. While not certified to FDA 21 CFR Part 11 out-of-the-box, the system’s deterministic operation, audit-ready manual logs, and stable mechanical architecture make it suitable for GLP-compliant workflows when integrated into validated SOPs. All wetted materials comply with USP Class VI biocompatibility standards and exhibit no leachables in ICH Q5A-relevant extraction studies. For volatile organic compound (VOC) or highly toxic analyte work (e.g., dioxins, PCBs), the unit is fully compatible with fume hood integration via flexible exhaust ducting.

Software & Data Management

The CM-12 operates as a standalone benchtop instrument with no proprietary software dependency. Temperature setpoints, timing sequences, and status indicators are managed exclusively through its front-panel LCD interface. All operational parameters—including real-time bath temperature, elapsed time, and alarm states—are retained in non-volatile memory during power interruption. For laboratories requiring electronic recordkeeping, external data loggers (e.g., Omega OM-DAQPRO-5300) may be connected via optional PT100 probe output (available upon request). The absence of embedded firmware or network connectivity simplifies 21 CFR Part 11 compliance pathways by eliminating electronic signature, audit trail, and system validation burdens—aligning with risk-based instrument qualification strategies outlined in ASTM E2500 and EU Annex 11.

Applications

• Agricultural residue testing: Concentration of QuEChERS extracts from fruits, vegetables, grains, and plant tissues prior to GC-MS/MS or LC-MS/MS analysis
• Pharmaceutical quality control: Solvent exchange and volume reduction of herbal extract fractions, dissolution media, and stability-indicating assay samples
• Environmental chemistry: Pre-concentration of EPA Methods 508, 525.3, and 8081B extracts from drinking water, wastewater, and sediment pore water
• Clinical toxicology: Preparation of plasma, serum, and urine samples for therapeutic drug monitoring and forensic screening
• Food safety: Cleanup and concentration steps in AOAC 2007.01 and EN 15662 multiresidue methods for mycotoxins, veterinary drugs, and process contaminants
• Materials science: Gentle drying of nanoparticle suspensions and polymer solutions where shear stress or localized overheating must be avoided

FAQ

Is the CM-12 compatible with ISO/IEC 17025-accredited laboratories?
Yes—the instrument supports metrological traceability through external calibration of its temperature sensor (PT100) and flow meter. Documentation templates for IQ/OQ/PQ are available upon request.
Can I use compressed air instead of nitrogen?
Yes. The dual-gas manifold allows switching between nitrogen (for oxidation-prone compounds) and filtered, oil-free compressed air (for robust analytes), with independent pressure regulation for each line.
What maintenance is required for long-term reliability?
Routine cleaning of the water bath with deionized water and periodic inspection of silicone tubing for cracking or swelling—no scheduled lubrication or firmware updates are needed.
Does the unit include a drain valve for bath water replacement?
Yes—a bottom-mounted brass drain valve enables rapid, spill-free bath fluid exchange without disassembly.
Is the CM-12 suitable for GMP-regulated environments?
It meets foundational GMP expectations for equipment design (cleanability, material compatibility, functional consistency) and can be incorporated into validated processes when paired with appropriate procedural controls and calibration records.